Reactive pseudosarcomatous response in urinary bladder

Roth, Julius A.

doi:10.1016/0090-4295(80)90578-6

Cited by 179 publications

(116 citation statements)

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“…Other studies have emphasized the role of prior inflammation, instrumentation, or surgery in IP or PSCN of bladder or ureter. Implicated associations include hysterectomy for leiomyoma (8), pyelonephritis (8), ruptured diverticulitis of the sigmoid colon with pseudotumor extending to the bladder (24), transurethral bladder resection (7), indwelling catheter (14) and cystitis (23,25). In our study, antecedent conditions in one of 13 IPs were neurogenic bladder secondary to cerebrovascular accident, and, in all PSCN, bladder biopsy or transurethral resection.…”

Section: Discussionmentioning

confidence: 63%

Inflammatory Pseudotumor and Sarcoma of Urinary Bladder: Differential Diagnosis and Outcome in Thirty-Eight Spindle Cell Neoplasms

et al. 2001

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We assessed diagnostic criteria among 38 spindle cell tumors of the urinary bladder and obtained follow-up in 36 patients. Patients comprised 28 males and 10 females aged 2.5 months to 87 years. Hematuria was the commonest presenting symptom (27 patients). After review and immunohistochemical workup, 17 patients had inflammatory pseudotumor (myofibroblastic tumor), 4 postoperative spindle cell nodule, 1 leiomyoma, 13 sarcoma (7 low-grade; 6 high-grade), and 3 carcinoma. Mean age was 38 years for pseudotumor (range 15 to 74), 65 for postoperative spindle cell nodule, 51 for sarcoma, and 76 for carcinoma. Size of pseudotumor averaged 4.4 ؎ 0.7 cm (range 1.5 to 13.0), similar to sarcoma, 4.0 ؎ 0.6 cm (range 0.5 to 7.0). Similar proportions of benign tumors and sarcomas had muscularis propria invasion. The criteria that best differentiated sarcoma from inflammatory pseudotumor were presence of necrosis at the tumordetrusor muscle interface in muscle-invasive cases, and nuclear atypia. Sarcoma also had less prominent microvasculature, less variable cellularity, consistently >1 mitotic figure per 10 high-power fields, and predominant acute inflammation without plasma cells. p53 protein nuclear immunostaining was moderate, unlike the rare to absent staining in pseudotumors. Because all 12 sarcomas were desmin-negative, we did not call them leiomyosarcoma; they overlapped with benign tumor in epithelial, mesenchymal, and actin immunostaining. Among 12 sarcoma patients, 2 died of tumor (at 3 months). Two of four experienced tumor recurrence after partial cystectomy (2 and 26 months). No pseudotumors recurred after transurethral resection or partial cystectomy, although one patient, 5 months after transurethral resection, had histologically identical pseudotumor that the surgeon considered residual. Another patient with pseudotumor, not a candidate for tumor ablation after transurethral resection, had continued tumor growth and he died of urosepsis. In conclusion, inflammatory pseudotumor, although overlapping with sarcoma in presentation, age range, and size, does not metastasize and remains histologically distinct from low-grade sarcoma.

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Section: Discussionmentioning

confidence: 63%

Inflammatory Pseudotumor and Sarcoma of Urinary Bladder: Differential Diagnosis and Outcome in Thirty-Eight Spindle Cell Neoplasms

et al. 2001

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“…The IMT and similar tumors were first seen in the lungs and published by Brunn et al in 1939 [2,3]. Roth was the first who reported a pseudosarcomatous tumor in the bladder in 1980 [4].…”

Section: Discussionmentioning

confidence: 80%

Inflammatory Pseudotumor of Perirenal Soft Tissue

Pramod¹,

Mishra²,

Nelvigi³

et al. 2014

JCR

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Abstract:Inflammatory pseudotumor or inflammatory myofibroblastic tumor (IMT) of kidney or perirenal soft tissue is rare benign lesion of unknown etiology, seen mostly in children and young adults. Less than forty cases have been found in the kidney, and less than five cases have been reported in the perirenal tissue. This tumor has been misdiagnosed by pathologists as myxoid leiomyosarcomas, and sarcomatoid carcinomas of kidney in the past. Immunohistochemistry is the key for the diagnosis and urologists should make their pathologists aware of the existence of such condition so that postoperatively benign nature of the condition and good prognosis can be explained to the patient.

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“…El pseudotumor inflamatorio, o tumor miofibroblastico fue descrito por primera vez en el hígado, en 1980 Roth informa del primer caso de afectación vesical 1 . El tumor miofibroblastico ha recibido distintos nombres, pseudotumor inflamatorio, pseudosarcoma fibromixoide, fascitis nodular, pseudosarcoma, proliferación miofibroblastica pseudosarcomatosa, nódulo postoperatorio de células de huso.…”

Section: Discussionunclassified

“…Macroscopicamente son tumores de tamaño variable desde los dos, hasta los 11 centíme-tros 1,4,7,[12][13][14][15] . Histológicamente son tumores de origen mesenquimal que tienen características patológicas similares a la fascitis nodular 14 .Esta compuesto por células fusiformes (células elongadas) que microscópica e inmunohistoquimicamente asemejan a miofibroblastos 5 .Las células fusiformes se agrupan formando husos, en un estroma de características mixoides y edematosa lleno de células inflamatorias y pequeños vasos sanguíneos 1 ; ocasionalmente se pueden apreciar glóbulos rojos.…”

Section: Discussionunclassified

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Tumor miofibroblástico de vejiga

García

Burgos

Fernández

et al. 2005

Actas Urológicas Españolas

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TUMOR MIOFIBROBLASTICO DE VEJIGA El tumor miofibroblásticos es un tumor mesenquimal benigno de carácter excepcional, siendo su localización mas habitual es el pulmón; mientras que su aparición en la vejiga, es excepcional, no existiendo mas de 100 casos publicados, de este tipo de tumor en la vejiga. Este tipo de tumor queclínica y radiológicamente, se comporta como un tumor maligno. El diagnóstico patológico es complejo, debido a su similitud con los sarcomas, siendo necesario recurrir a la inmunohistoquímica para un diagnostico de certeza.El tratamiento mediante resección amplia suele ser suficiente no existiendo en la actualidad ningún caso de metástasis a distancia, ni de malignizacion. Presentamos un nuevo caso de este tumor, realizando una amplia revisión bibliográfica.Palabras clave: Pseudotumor inflamatorio. Pseudosarcoma vesical. ABSTRACT MIOFIBROBLASTIC TUMOR OF BLADDERThe miofibroblastic tumor, is a mesenchimal benign tumor of exceptional character, being its localization but habitual it is the lung; while its appearance in the bladder, is exceptional, not existing but of 100 published cases, of this tumor type in the bladder. This tumor type that clinic and radiologics, behave as a wicked tumor. The pathological diagnosis is complex, due to its similarity with the sarcomas, being necessary to appeal to the inmunohistoquimics for a I diagnose of certainty.The treatment by means of wide resection is usually enough not existing any case of metastasis at the present time at distance, neither of malignization. We present a new case of this neoplasm, carrying out a wide bibliographical revision.

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Reactive pseudosarcomatous response in urinary bladder

Cited by 179 publications

References 9 publications

Inflammatory Pseudotumor and Sarcoma of Urinary Bladder: Differential Diagnosis and Outcome in Thirty-Eight Spindle Cell Neoplasms

Inflammatory Pseudotumor and Sarcoma of Urinary Bladder: Differential Diagnosis and Outcome in Thirty-Eight Spindle Cell Neoplasms

Inflammatory Pseudotumor of Perirenal Soft Tissue

Tumor miofibroblástico de vejiga

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