Reactive polymers: design considerations, novel preparations and selected applications in organic chemistry

Fréchet, Jean M. J.; Darling, Graham D.; Itsuno, Shinichi; Lü, Ping; Mefiahi, M. V. de; Rolls, Wesley A.

doi:10.1351/pac198860030353

Cited by 52 publications

(19 citation statements)

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“…11,12 Nevertheless, a series of different reactive polymers had already been described in the past. 13 The chemistry of activated esters in polymer synthesis, however, has been neglected in recent years because of the dominating popularity of 1,3-dipolar cycloadditions. The goal of this mini-review is to highlight and categorize the recent trends in the synthesis of well-defined polymeric active esters.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of well‐defined polymeric activated esters

Théato

2008

J. Polym. Sci. A Polym. Chem.

276

260

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Monomers bearing an activated ester group can be polymerized under various controlled polymerization techniques, such as ATRP, NMP, RAFT polymerization, or ROMP. Combining the functionalization of polymers via polymeric activated esters with these controlled polymerization techniques generate possibilities to realize highly functionalized polymer architectures. Within this highlight two different research areas of activated esters in polymer science will be discussed: (i) the preparation of defined reactive polymer architectures by controlled polymerization techniques and (ii) the preparation of defined reactive thin films. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 6677–6687, 2008

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Section: Introductionmentioning

confidence: 99%

“…Nevertheless, a series of different reactive polymers had already been described in the past 13. The chemistry of activated esters in polymer synthesis, however, has been neglected in recent years because of the dominating popularity of 1,3‐dipolar cycloadditions.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of well‐defined polymeric activated esters

Théato

2008

J. Polym. Sci. A Polym. Chem.

276

260

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“…The authors discussed an alternative mechanism resulting from the potential incomplete reduction of the nitro group to the hydroxylamine. The route was expanded to the synthesis of 4-phenyl-2,3-dihydro-1H-benzo[b] [1,4]diazepines 243 using chloropropiophenone.…”

Section: Fused Heterocyclesmentioning

confidence: 99%

“…Straightforward stereochemically controlled synthesis of 1,7,8,9a-tetrahydropyrazino[2,1-c] [1,4]oxazine-6,9-diones was reported by Soural et al 196 Resin-bound O-t-Bu-protected Fmoc-serine was converted to 4-Ns derivative 577 (Scheme 108) and activated for alkylation with bromoketones, and the alkylation was followed by 4-Ns-deprotection (resin 578). The ketones in the synthesis of fused [6 + 6] species gave pyrazinooxazines 583, whereas the cyclization of fused [5 + 6] thiohydantoins 176 was unsuccessful (484, Scheme 88).…”

Section: Chemical Reviewsmentioning

confidence: 99%

Traceless Solid-Phase Organic Synthesis

2019

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Traceless solid-phase synthesis represents an ultimate sophisticated synthetic strategy on insoluble supports. Compounds synthesized on solid supports can be released without a trace of the linker that was used to tether the intermediates during the synthesis. Thus, the target products are composed only of the components (atoms, functional groups) inherent to the target core structure. A wide variety of synthetic strategies have been developed to prepare products in a traceless manner, and this review is dedicated to all aspects of traceless solid-phase organic synthesis. Importantly, the synthesis does not need to be carried out on a linker designed for traceless synthesis; most of the synthetic approaches described herein were developed using standard, commercially available linkers (originally devised for solid-phase peptide synthesis). The type of structure prepared in a traceless fashion is not restricted. The individual synthetic approaches are divided into eight sections, each devoted to a different methodology for traceless synthesis. Each section consists of a brief outline of the synthetic strategy followed by a description of individual reported syntheses.

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“…[22][23][24][25][26][27][28][29][30] Reactive polymers can be expected to exhibit additional properties by undergoing modification to produce many other polymers by polymer reactions; in addition to this, they are also expected to be used as cross-linking reagents, resist materials and so on. We have already reported the use of formyl or acetyl group-containing novolacs as reactive phenolic resins.…”

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confidence: 99%