Reactive Perforating Collagenosis Associated with Diabetes Mellitus

Poliak, Susana C.; Lebwohl, Mark; Parris, Anthony; Prioleau, Philip G.

doi:10.1056/nejm198201143060206

Cited by 94 publications

(67 citation statements)

References 7 publications

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“…In their original report, they postulated that mild superficial trauma in genetically susceptible individuals leads to necrobiosis of dermal collagen in the papillary dermis, which is subsequently extruded by TEE. Poliak et al [5]were the first to report RPC in adults with diabetes mellitus. Faver et al [6]proposed the following diagnostic criteria for APD: (1) histopathological findings of elimination of necrotic basophilic collagen tissue into a cup-shaped epidermal depression, (2) clinical presentation of umbilicated papules or nodules with a central adherent keratotic plug, and (3) onset of skin lesions after the age of 18 years.…”

Section: Discussionmentioning

confidence: 99%

Acquired Perforating Dermatosis in a Patient with Poland Syndrome

Fistarol

Itin²

2003

Dermatology

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Acquired perforating dermatosis (APD) is characterized by umbilicated 1- to 10-mm-measuring papulonodules with a central adherent oystershell-like keratotic plug, typically on the dorsa of the hands, forearms and over the knees. APD is associated with systemic diseases, especially diabetes mellitus and/or renal failure. Histologically the lesions show transepidermal elimination of altered dermal components into a cup-shaped epidermal depression. We present a 69-year-old man with coexisting APD and Poland syndrome (PS), an association not yet described. PS (OMIM 173800) is a rare congenital anomaly consisting of unilateral partial or total absence of the greater pectoralis muscle and ipsilateral symbrachydactyly. Most cases of PS are sporadic as it was in our case. Our patient had, in addition, an untreated diabetic condition, hyperuricaemia, dilated cardiomyopathy and a very recent pulmonary embolism. He responded to therapy with allopurinol.

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Section: Discussionmentioning

confidence: 99%

Acquired Perforating Dermatosis in a Patient with Poland Syndrome

Fistarol

Itin²

2003

Dermatology

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“…The childhood or inherited form and the adult or acquired form are clinically and histologically identical. The acquired form is nonfamilial, has no predilection to sex, and is often associated with systemic diseases such as chronic renal failure and diabetes mellitus [5,6]. Multiple recurrent, umbilicated, hyperpigmented papules and nodules with a central adherent keratotic plug occur on the extensor surfaces of the extremities and on areas that can be reached by the hands [7] and spontaneously resolve in 6-8 weeks leaving a hypopigmented macule or scar [8].…”

Section: Discussionmentioning

confidence: 99%

Koebnerization of reactive perforating collagenosis induced by laser hair removal

2003

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Laser hair removal, due to demonstrated efficacy and safety, has become a commonly performed office procedure. We report an unusual occurrence after laser hair removal with the 800 nm diode laser that previously has never been described. After laser hair removal treatment to the ventral surface of the ears, a patient developed lesions of previously diagnosed reactive perforating collagenosis. Interestingly, the lesions appeared on the dorsal surface of the ears. Perhaps the koebner phenomenon was invoked as the laser energy penetrated to the untreated dorsal surface, which was not protected by epidermal contact cooling.

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“…In 1982 Poliak et al [9] described a reac tive perforating collagenosis associated with diabetes mellitus in 6 patients of which 4 al so had involvement of the trunk and 2 of the face. All were adult and all had accompany ing retinopathy and 5 nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Progressive Generalized Perforating Folliculitis

Zachariae¹,

Søgaard²

1984

Dermatology

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A case is presented of a 52-year-old female exhibiting a severe progressive generalized perforating folliculitis accompanied by widespread erythroderma, follicular hyperkeratosis, keratoderma of palms and soles, alopecia of scalp and eyebrows, and nail changes. The disease seemed completely resistant to steroids, adrenocorticotropin, PUVA, cytostatic drugs, and aromatic retinoids. This type of skin reaction does not seem to have been described in the dermatologic literature.

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Reactive Perforating Collagenosis Associated with Diabetes Mellitus

Cited by 94 publications

References 7 publications

Acquired Perforating Dermatosis in a Patient with Poland Syndrome

Acquired Perforating Dermatosis in a Patient with Poland Syndrome

Koebnerization of reactive perforating collagenosis induced by laser hair removal

Progressive Generalized Perforating Folliculitis

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