Reactive Perforating Collagenosis

Weiner, Alfred L.

doi:10.1001/archderm.1970.04000110056011

Cited by 35 publications

(15 citation statements)

References 5 publications

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“…This implies, whatever the family history of RPC, not only the need for careful examination of all family members who may pay scant attention to few, occasional, episodic and localized eruptions, but also the extreme variability and subtle nature in expression of the genetic defect. This variation of RPC has been seen in siblings where one had mild lesions with longer periods of remission than the other, in whom they were continuously present 18 . Though asymptomatic, the lesions may keep appearing throughout life, 17 secondary bacterial infection being the common complication 18 .…”

Section: Discussionmentioning

confidence: 94%

“…This variation of RPC has been seen in siblings where one had mild lesions with longer periods of remission than the other, in whom they were continuously present. 18 Though asymptomatic, the lesions may keep appearing throughout life, 17 secondary bacterial infection being the common complication. 18 Scarring is generally insignificant with slight atrophy and temporary pigmentary changes.…”

Section: Discussionmentioning

confidence: 99%

“…18 Though asymptomatic, the lesions may keep appearing throughout life, 17 secondary bacterial infection being the common complication. 18 Scarring is generally insignificant with slight atrophy and temporary pigmentary changes. 17,19 Nonetheless, three of our patients had visible scars on the face.…”

Section: Discussionmentioning

confidence: 99%

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Familial reactive perforating collagenosis: a clinical, histopathological study of 10 cases

Ramesh¹,

Sood²,

Kubba

et al. 2007

Acad Dermatol Venereol

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Familial RPC can remain quiescent for a long period and the inherited defect not only shows extreme variability in expression but also demonstrates that lesions can be few and localized so as to escape notice in individuals and family members presenting with this benign, uncommon and self-subsiding dermatosis. In all patients topical retinoic acid was helpful in early regression. Sunscreens may mitigate the severity of RPC in those whose lesions are precipitated in summer but this needs further evaluation.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Familial reactive perforating collagenosis: a clinical, histopathological study of 10 cases

Ramesh¹,

Sood²,

Kubba

et al. 2007

Acad Dermatol Venereol

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“…Reactive perforating collagenosis is a rare inherited type of transepidermal elimination disorder, wherein collagen is extruded through the epidermis 1 . The exact cause is unknown, but it is often familial with an autosomal dominant or recessive inheritance 3,4 . The basic defect is a focal damage to collagen, which is extruded through a necrolytic epidermis 5 .…”

Section: Discussionmentioning

confidence: 99%

“…1 The exact cause is unknown, but it is often familial with an autosomal dominant or recessive inheritance. 3,4 The basic defect is a focal damage to collagen, which is extruded through a necrolytic epidermis. 5 There have been only 50 case reports in world literature.…”

Section: Discussionmentioning

confidence: 99%