Reactive oxygen species scavenging by hemin-based nanosheets reduces Parkinson’s disease symptoms in an animal model

Li, Lei; Tu, Qiuxia; Jiao, Lei; Song, Xiang; Wang, Li; Ran, Xia; Xiao, Bo; Feng, Guangwei; Feng, Jian; Zhang, Chunlin

doi:10.1016/j.cej.2021.134356

Cited by 19 publications

(15 citation statements)

References 58 publications

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“…With high caloric intake, the mitochondrial respiratory chains obtain a high number of electrons, leading to the production of a large amount of superoxide anion. , Consumption of a high-fat diet (HFD) contributes to the development of obesity and related metabolic disorders, which induces the chronic state of inflammation via the production of white adipose tissues that secrete proinflammatory cytokines. These proinflammatory cytokines mediate the activation of immune cells that induces the generation of a high level of ROS .…”

Section: Sources Of Rosmentioning

confidence: 99%

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Anik

Mahmud²,

Masud

et al. 2022

ACS Appl. Bio Mater.

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Research on the role of reactive oxygen species (ROS) in the aging process has advanced significantly over the last two decades. In light of recent findings, ROS takes part in the aging process of cells along with contributing to various physiological signaling pathways. Antioxidants being cells' natural defense mechanism against ROS-mediated alteration, play an imperative role to maintain intracellular ROS homeostasis. Although the complete understanding of the ROS regulated aging process is yet to be fully comprehended, current insights into various sources of cellular ROS and their correlation with the aging process and age-related diseases are portrayed in this review. In addition, results on the effect of antioxidants on ROS homeostasis and the aging process as well as their advances in clinical trials are also discussed in detail. The future perspective in ROS-antioxidant dynamics on antiaging research is also marshaled to provide future directions for ROS-mediated antiaging research fields.

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Section: Sources Of Rosmentioning

confidence: 99%

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Anik

Mahmud²,

Masud

et al. 2022

ACS Appl. Bio Mater.

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show abstract

“…90 Ren et al 91 demonstrated that graphene oxide quantum dots exhibited neuroprotective effects by effectively scavenging MPP + -induced ROS, mitochondrial damage, cell toxicity, and apoptosis. Lei et al 92 used ultra-thin graphite-carbon nitride (g-C 3 N 4 ) nanosheets to enhance the peroxidase activity of hemin and restore dopaminedependent behavior of PD nematode model by reducing ROS-mediated neurotoxicity.…”

Section: Alleviation Of Oxidative Stressmentioning

confidence: 99%

Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles

Liu

Hua

Zheng

et al. 2023

MedComm – Biomaterials and Applications

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With the aging of global population, the early diagnosis and treatment of neurodegenerative diseases such as Parkinson's disease (PD) have attracted considerable attention. Despite great advances achieved during the past decades, PD as the second largest neurodegenerative disease is still incurable. In the clinical practice, PD patients are mainly treated by drugs, and supplemented with deep brain stimulation or nerve nucleus destruction. The existing drugs can only relieve the symptoms of motor disorder, and cannot stop the progression of PD. Compared with small molecular drugs, nanoparticles exhibit multiple functions in the neuroprotection and neurorepair due to their tunable physical and chemical properties, easy modification and functionalization. Herein, we first briefly review the characteristics of nanoparticles crossing the blood–brain barrier, which is a primary challenge for the treatment of PD. Then, we summarize the pathologic mechanisms of PD and comprehensively discuss the novel PD therapy based on diverse nanoparticles, including alleviating oxidative stress, scavenging α‐synuclein aggregates, chelating metal ions, delivering neurotrophic factors and genes, and transplanting stem cells. This review aims to highlight the great potential of advanced nanoparticles in the therapy of PD.

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“…[83] The oxidized molecules of proteins, like Aβ, interfere with the use of metals by brains, leading to neurodegenerative diseases. [3] Consequently, the redox modulatory nanozymes, such as Mn 3 O 4 nanoflowers, [84] ultrasmall lactoferrin-modified Au-Bi 2 Se 3 , [85] CeO 2 , [86] hemin with g-C 3 N 4 nanosheets, [87] PB, [88] etc., have been applied to neurological disorder therapy.…”

Section: Nanozymes For Neurological Disordersmentioning

confidence: 99%

Nanozyme‐Enabled Treatment of Cardio‐ and Cerebrovascular Diseases

Zhang

Liu

Wang

et al. 2022

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Cardio‐ and cerebrovascular diseases are two major vascular‐related diseases that lead to death worldwide. Reactive oxygen species (ROS) play a vital role in the occurrence and exacerbation of diseases. Excessive ROS induce cellular context damage and lead to tissue dysfunction. Nanozymes, as emerging enzyme mimics, offer a unique perspective for therapy through multifunctional activities, achieving essential results in the treatment of ROS‐related cardio‐ and cerebrovascular diseases by directly scavenging excess ROS or regulating pathologically related molecules. This review first introduces nanozyme‐enabled therapeutic mechanisms at the cellular level. Then, the therapies for several typical cardio‐ and cerebrovascular diseases with nanozymes are discussed, mainly including cardiovascular diseases, ischemia reperfusion injury, and neurological disorders. Finally, the challenges and outlooks for the application of nanozymes are also presented. This review will provide some instructive perspectives on nanozymes and promote the development of enzyme‐mimicking strategies in cardio‐ and cerebrovascular disease therapy.

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Reactive oxygen species scavenging by hemin-based nanosheets reduces Parkinson’s disease symptoms in an animal model

Cited by 19 publications

References 58 publications

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles

Nanozyme‐Enabled Treatment of Cardio‐ and Cerebrovascular Diseases

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