Reactive oxygen species scavenging activities in a chemiluminescence model and neuroprotection in rat pheochromocytoma cells by astaxanthin, beta‐carotene, and canthaxanthin

Chang, Cheng-Chen; Chang, Chia-Ying; Lai, Guia-Hung

doi:10.1016/j.kjms.2012.12.002

Cited by 55 publications

(27 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Astaxanthin (at 10 µM) exhibited stronger activity than β-carotene and canthaxanthin in reducing the cytotoxicity induced by Aβ 25-35 (Chang et al, 2013).…”

Section: Accepted Manuscriptmentioning

confidence: 96%

In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ1-42) toxicity and aggregation

Alghazwi

Smid

Musgrave

et al. 2019

Neurochemistry International

View full text Add to dashboard Cite

Amyloid beta (Aβ) can aggregate and form plaques, which are considered as one of the major hallmarks of Alzheimer's disease. This study aims to directly compare the neuroprotective activities in vitro of two marine-derived carotenoids astaxanthin and fucoxanthin that have shown a spectrum of biological activities, including neuroprotection. The in vitro neuroprotective activities were investigated against Aβ 1-42-mediated toxicity in pheochromocytoma (PC-12) neuronal cells using the MTT cell viability assay, anti-apoptotic, antioxidant and neurite outgrowth activities; as well as inhibition against Aβ 1-42 fibrillization in the Thioflavin T (ThT) assay of fibril kinetics and via transmission electron microscopic (TEM) evaluation of fibril morphology. The results demonstrated that both astaxanthin and fucoxanthin exhibited multineuroprotective effects favouring fucoxanthin over astaxanthin supporting neuroprotective roles of marine-derived carotenoids as potential novel dementia prevention or therapeutic strategies.

show abstract

“…Astaxanthin (at 10 µM) exhibited stronger activity than β-carotene and canthaxanthin in reducing the cytotoxicity induced by Aβ 25-35 (Chang et al, 2013).…”

Section: Accepted Manuscriptmentioning

confidence: 96%

In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ1-42) toxicity and aggregation

Alghazwi

Smid

Musgrave

et al. 2019

Neurochemistry International

View full text Add to dashboard Cite

show abstract

“…In general, canthaxanthin scavenges reactive oxygen species , but canthaxanthin does not seem to scavenge peroxynitrite anion free radicals (ONOO − ) . Geometrical isomerization seems to have an impact in terms of the free radical scavenging activity of canthaxanthin .…”

Section: Potential Health Benefitsmentioning

confidence: 99%

Canthaxanthin: From molecule to function

Esatbeyoglu¹,

Rimbach²

2016

Molecular Nutrition Food Res

View full text Add to dashboard Cite

The aim of this review is to summarize the relevant literature about the use of canthaxanthin in food science and nutrition research. Canthaxanthin is a red-orange carotenoid that belongs to the xanthophyll group. This naturally occurring pigment is present in bacteria, algae and some fungi. Canthaxanthin is also responsible for the color of flamingo feathers, koi carp skin and crustacean shells. Canthaxanthin is widely used in poultry (broiler, laying hens) as a feed additive. Canthaxanthin can be obtained by total synthesis. The canthaxanthin-mediated color of foods is an important quality criterion for consumers. Recently, the potential health-promoting effects of canthaxanthin have been discussed. Canthaxanthin enrichment of LDL has the potential to protect cholesterol from oxidation. In addition to its free radical scavenging and antioxidant properties (e.g., the induction of catalase and superoxide dismutase), canthaxanthin's immunomodulatory activity (e.g., enhancing the proliferation and function of immune competent cells) and its important role in gap junction communication (e.g., induction of the transmembrane protein connexin 43) have been reported. Many studies regarding the potential health benefits of canthaxanthin have been conducted in vitro and should be validated in appropriate in vivo models.

show abstract

“…48 CX is also an antioxidant and may have great potential in the treatment of neurological diseases. It has been found that CX has antioxidant, anti-apoptosis and immunomodulatory activity, [30][31][32]49 but the cell membrane receptors were not identified and the mechanism of these effects were not clear. TMEM16A mediate diverse physiology in cells, which play important roles in nociception, transduction of nerves, contraction of smooth muscle, epithelial Cl − secretion and fertilization.…”

Section: Discussionmentioning

confidence: 99%

“…30 In addition, CX has been shown to have the ability of scavenging free radicals and reactive oxygen species (ROS). 31 Studies have found that excessive production of ROS activates apoptotic signals and causes apoptosis. 32 In this study, we identified CX as a natural TMEM16A activator that has highly efficient, target specific and nontoxic properties, and further explored the putative binding site between CX and TMEM16A using molecular docking and site-directed mutation methods.…”

Section: Introductionmentioning

confidence: 99%

Activation of TMEM16A by natural product canthaxanthin promotes gastrointestinal contraction

Shi

Guo

et al. 2020

FASEB j.

View full text Add to dashboard Cite

Transmembrane 16A (TMEM16A), also known as anoctamin 1, is the molecular basis of the calcium‐activated chloride channels. TMEM16A is present in interstitial cells of Cajal, which are the pacemaker cells that control smooth muscle contraction. TMEM16A is implicated in gastrointestinal disorders. Activation of TMEM16A is believed to promote the gastrointestinal muscle contraction. Here, we report a highly efficient, nontoxic, and selective activator of TMEM16A, canthaxanthin (CX). The study using molecular docking and site‐directed mutation revealed that CX‐specific binging site in TMEM16A is K769. CX was also found to promote the contraction of smooth muscle cells in gastrointestinal tract through activation of TMEM16A channels, which provides an excellent basis for development of CX as a chemical tool and potential therapeutic for gastrointestinal dysfunction.

show abstract

Reactive oxygen species scavenging activities in a chemiluminescence model and neuroprotection in rat pheochromocytoma cells by astaxanthin, beta‐carotene, and canthaxanthin

Cited by 55 publications

References 25 publications

In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ1-42) toxicity and aggregation

In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ1-42) toxicity and aggregation

Canthaxanthin: From molecule to function

Activation of TMEM16A by natural product canthaxanthin promotes gastrointestinal contraction

Contact Info

Product

Resources

About