Reactive Oxygen Species Scavenger in Acute Intracerebral Hemorrhage Patients

Kim, M. H.; Byun, Joonho; Chung, Yeongu; Lee, Si Un; Park, Ji Eun; Park, Wonhyoung; Park, Jung Cheol; Ahn, Jae Sung; Lee, Seungjoo

doi:10.1161/strokeaha.120.032266

Cited by 11 publications

(3 citation statements)

References 29 publications

(3 reference statements)

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“…Here, we report the pharmacology of different organic, inorganic, and synthetic selenocompounds against ferroptosis in vitro, and demonstrate that selenocystamine and methylselenocysteine are protective in the MCAO model, where ferroptosis is implicated. The translational potential of selenium for stroke is evidenced by a recent study that demonstrated that combined use of selenite with another anti-ferroptotic compound, N-acetylcysteine, improved multiple outcomes in a clinical trial of 123 patients with intracerebral haemorrhage [26]. This clinical trial supports prior findings in animal models that use selenium for hemorrhagic and ischemic stroke.…”

Section: Discussionsupporting

confidence: 69%

Characterization of Selenium Compounds for Anti-ferroptotic Activity in Neuronal Cells and After Cerebral Ischemia–Reperfusion Injury

et al. 2021

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The emergence of ferroptosis as a cell death pathway associated with brain disorders including stroke and neurodegenerative diseases emphasizes the need to develop therapeutics able to target the brain and to protect neurons from ferroptotic death. Selenium plays an essential role in reducing lipid peroxidation generated during ferroptosis through its incorporation into the catalytic site of glutathione peroxidase 4. Here, we compared the anti-ferroptotic activity of several organic and inorganic selenium compounds: methylselenocysteine, selenocystine, selenomethionine, selenocystamine, ebselen, sodium selenite, and sodium selenate. All were effective against erastin-and RSL3-induced ferroptosis in vitro. We characterized the ability of the selenium compounds to release selenium and boost glutathione peroxidase expression and activity. Based on our results, we selected organic selenium compounds of similar characteristics and investigated their effectiveness in protecting against neuronal death in vivo using the cerebral ischemia-reperfusion injury mouse model. We found that pretreatment with methylselenocysteine or selenocystamine provided protection from ischemia-reperfusion neuronal damage in vivo. These data support the use of ferroptosis inhibitors for treatment and select selenium compounds for prevention of neuronal damage in ischemic stroke and other diseases of the brain where ferroptosis is implicated.

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“…As a free radical scavenger, Nxy-059 showed good safety and tolerability in its ICH efficacy study, but unfortunately efficacy itself was not shown to be significant (Lyden et al, 2007). In the most recent study on ROS scavengers, the combination of N-acetylcysteine and selenium significantly slowed the progression of perihematomal edema in patients with ICH and reduced the time to reach the target Richmond Agitation Sedation Scale (RASS) and the length of stay in the ICU, although there was no significant change in neurological outcomes (Kim et al, 2021). As a free radical scavenger, edaravone has been used in Japan in patients with Group, 2003;Nakamura et al, 2008;Shang et al, 2015;Shimizu et al, 2021).…”

Section: Neutralizing Excessive Free Radicals Produced By Oxidative S...mentioning

confidence: 99%

Secondary Brain Injury by Oxidative Stress After Cerebral Hemorrhage: Recent Advances

Shao

Chen²,

Ma³

2022

Front. Cell. Neurosci.

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Intracerebral hemorrhage (ICH) is a clinical syndrome in which blood accumulates in the brain parenchyma because of a nontraumatic rupture of a blood vessel. Because of its high morbidity and mortality rate and the lack of effective therapy, the treatment of ICH has become a hot research topic. Meanwhile, Oxidative stress is one of the main causes of secondary brain injury(SBI) after ICH. Therefore, there is a need for an in-depth study of oxidative stress after ICH. This review will discuss the pathway and effects of oxidative stress after ICH and its relationship with inflammation and autophagy, as well as the current antioxidant therapy for ICH with a view to deriving better therapeutic tools or targets for ICH.

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“…Kim et al 8 provide promising preliminary results suggesting that PHE can be mitigated safely through supplemental antioxidant therapy with reactive oxygen species scavengers. In demonstrating a reduction in PHE volume with combined N-acetylcysteine and selenium treatment, the present trial has succeeded where the previous CHANT trial (Cerebral Hematoma and NXY Treatment) using the free radical scavenger NXY-059 did not-albeit the trial was limited by measuring PHE as a secondary outcome and at 72 hours.…”

Section: See Related Article P 1172mentioning

confidence: 99%

Combatting Secondary Injury From Intracerebral Hemorrhage With Supplemental Antioxidant Therapy

Shoamanesh

Katsanos

2021

Stroke

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Reactive Oxygen Species Scavenger in Acute Intracerebral Hemorrhage Patients

Cited by 11 publications

References 29 publications

Characterization of Selenium Compounds for Anti-ferroptotic Activity in Neuronal Cells and After Cerebral Ischemia–Reperfusion Injury

Secondary Brain Injury by Oxidative Stress After Cerebral Hemorrhage: Recent Advances

Combatting Secondary Injury From Intracerebral Hemorrhage With Supplemental Antioxidant Therapy

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