Reactive Oxygen Species, Cancer and Anti-Cancer Therapies

Manda, Gina; Nechifor, Marina Tamara; Neagu, Teodora-Monica

doi:10.2174/2212796810903010022

Cited by 47 publications

(11 citation statements)

References 233 publications

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“…In general, cancer cells contain a larger concentration of hydrogen peroxide and superoxide due to their higher ROS homeostasis . Furthermore, X‐ray irradiation of cancer cells preferentially stimulates the generation of hydrogen peroxide and superoxide through the interaction with mitochondria . The mitochondrial superoxide level in MCF‐7 cells incubated with pristine or PA‐SAM functionalized CoFe 2 O 4 MNPs was found to even increase when left nonirradiated (Figure c).…”

Section: Resultsmentioning

confidence: 97%

Enhanced In Vitro Biocompatibility and Water Dispersibility of Magnetite and Cobalt Ferrite Nanoparticles Employed as ROS Formation Enhancer in Radiation Cancer Therapy

Klein

Kızaloğlu

Portilla

et al. 2018

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Efficient magnetic reactive oxygen species (ROS) formation enhancing agents after X-ray treatment are realized by functionalizing superparamagnetic magnetite (Fe O ) and Co-ferrite (CoFe O ) nanoparticles with self-assembled monolayers (SAMs). The Fe O and CoFe O nanoparticles are synthesized using Massart's coprecipitation technique. Successful surface modification with the SAM forming compounds 1-methyl-3-(dodecylphosphonic acid) imidazolium bromide, or (2-{2-[2-hydroxy-ethoxy]-ethoxy}-ethyl phosphonic acid provides biocompatibility and long-term stability of the Fe O and CoFe O nanoparticles in cell media. The SAM-stabilized ferrite nanoparticles are characterized with dynamic light scattering, X-ray powder diffraction, a superconducting quantum interference device, Fourier transform infrared attenuated total reflectance spectroscopy, zeta potential measurements, and thermogravimetric analysis. The impact of the SAM-stabilized nanoparticles on the viability of the MCF-7 cells and healthy human umbilical vein endothelial cells (HUVECs) is assessed using the neutral red assay. Under X-ray exposure with a single dosage of 1 Gy the intracellular SAM stabilized Fe O and CoFe O nanoparticles are observed to increase the level of ROS in MCF-7 breast cancer cells but not in healthy HUVECs. The drastic ROS enhancement is associated with very low dose modifying factors for a survival fraction of 50%. This significant ROS enhancement effect by SAM-stabilized Fe O and CoFe O nanoparticles constitutes their excellent applicability in radiation therapy.

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Section: Resultsmentioning

confidence: 97%

Enhanced In Vitro Biocompatibility and Water Dispersibility of Magnetite and Cobalt Ferrite Nanoparticles Employed as ROS Formation Enhancer in Radiation Cancer Therapy

Klein

Kızaloğlu

Portilla

et al. 2018

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“…In marine ecosystems, the respiration of organisms, the decomposition of organic matter by bacteria and the lack of water column mixing (for example, in bays and estuaries [ Diaz, 2001 ]), or the effect of tides exposing intertidal species to air or confining them in rockpools or sediments can create chronic hypoxia ( Mcmahon, 1988 ), associated with an increased production of DNA-damaging reactive oxygen species (ROS [ Hermes-Lima and Zenteno-Savín, 2002 ]). Exposure to ROS is linked to an increase in cancer risk ( Nechifor et al., 2012 ; Valko et al., 2006 ), which is mitigated by production of antioxidant molecules and enzymes, incurring an additional energetic cost compared with species inhabiting normoxic environments ( Hermes-Lima and Zenteno-Savín, 2002 ). Although chronic hypoxia is currently exacerbated by anthropogenic factors ( Diaz, 2001 ), sediment records and modeling indicates whole marine ecosystems had large areas exposed to climate-driven chronic hypoxia over geological-scale time periods ( Praetorius et al., 2015 ; Zillén et al., 2008 ).…”

Section: Costs At Different Organizational Levelsmentioning

confidence: 99%

Ecological and Evolutionary Consequences of Anticancer Adaptations

et al. 2020

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Summary Cellular cheating leading to cancers exists in all branches of multicellular life, favoring the evolution of adaptations to avoid or suppress malignant progression, and/or to alleviate its fitness consequences. Ecologists have until recently largely neglected the importance of cancer cells for animal ecology, presumably because they did not consider either the potential ecological or evolutionary consequences of anticancer adaptations. Here, we review the diverse ways in which the evolution of anticancer adaptations has significantly constrained several aspects of the evolutionary ecology of multicellular organisms at the cell, individual, population, species, and ecosystem levels and suggest some avenues for future research.

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“…After longer treatment times (12 h), the ROS level started to increase to the basic levels (500 and 1000 μg.mL -1 ) or even more (2000 μg.mL -1 ). These different effects of the olive extract on ROS levels of the normal and cancerous cells can be related to the inherent differences between basic ROS levels and anti-oxidant defense systems of both cells (27, 28). In fact, it has been suggested that compared to the normal cells, cancerous cells are under a chronic oxidative stress and are more susceptible to the ROS manipulating strategies than normal cells (29, 30).…”

Section: Discussionmentioning

confidence: 99%

Anti-oxidant and Selective Anti-proliferative Effects of the Total Cornicabra Olive Polyphenols on Human Gastric MKN45 Cells

et al. 2019

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Background According to the epidemiological studies, consuming olive products can decrease the incidence of the different types of cancers mostly due to the high anti-oxidant properties of their polyphenolic compounds. Objectives To evaluate the anti-oxidant and anti-proliferative potentials of the olive fruits total polyphenols on the gastric adenocarcinoma MKN45 cells in comparison to the normal Hu02 cells. Materials and Methods The total phenolic content of the olive fruits and radical scavenging activity were determined by Folin and 2,2-diphenyl-1-picrylhydrazyl (DPPH) tests respectively. MTT assay was performed for the evaluation of the cell viability. Intracellular reactive oxygen species (ROS) level was measured using DCFH-DA. Statistical analysis was performed using SPSS 16 statistical software. Results Treatment of the MKN45 cells with the phenolic compounds extracted from olive fruits decreased growth and viability of the cells in a dose- and time-dependent manner. In addition, treatment of the MKN45 cells with a combination of the phenolic compounds extracts and cytarabine further decreased cell compared to monotherapy of the cells with each compound alone. Mechanistically, we showed that the anti-cancer effects of the olive polyphenols in the MKN45 cells are mediated through depletion of ROS. Similarly, polyphenolic extracts were found to decrease ROS level in the normal cells at the concentrations of 500 and 1000 μg.mL -1 and short treatment times (6 h), but the viability of these cells did not significantly change. At high concentrations (2000 μg.mL -1 ) of the phenolic extracts or at longer times of incubation (12 h), however, both ROS levels and the viability of the cells were significantly decreased in the normal cells. Conclusions The olive fruits polyphenolic extract modulates ROS levels and selectively targets cancerous cells at low concentrations. Also, the effects of cytarabine could be potentiated by the olive fruits polyphenols. Thus, for a combined protocol of cancer cell therapy, olive fruit polyphenolic compound could be proposed as a proper candidate.

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Reactive Oxygen Species, Cancer and Anti-Cancer Therapies

Cited by 47 publications

References 233 publications

Enhanced In Vitro Biocompatibility and Water Dispersibility of Magnetite and Cobalt Ferrite Nanoparticles Employed as ROS Formation Enhancer in Radiation Cancer Therapy

Enhanced In Vitro Biocompatibility and Water Dispersibility of Magnetite and Cobalt Ferrite Nanoparticles Employed as ROS Formation Enhancer in Radiation Cancer Therapy

Ecological and Evolutionary Consequences of Anticancer Adaptations

Anti-oxidant and Selective Anti-proliferative Effects of the Total Cornicabra Olive Polyphenols on Human Gastric MKN45 Cells

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