Reactive oxygen species and related haem pathway components as possible epigenetic modifiers in neurobehavioural pathology

Gericke, Gerda J.

doi:10.1016/j.mehy.2005.07.031

Cited by 10 publications

(4 citation statements)

References 81 publications

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“…While to some extent hyperoxia may be well tolerated by tissues, it would be prudent to avoid extreme hyperoxia 225 . Although oxygen toxicity may not be imminently overt, an overdose of O 2 is likely to trigger molecular responses such as cell cycle arrest and epigenetic modifications, 226,227 which would oppose healing. Second, approaches to keep a wound oxygenated over a longer period of time, as opposed to a few hours usually targeted in HBO therapy, should prove to be beneficial.…”

Section: Tissue Oxygenation and Wound Therapymentioning

confidence: 99%

Wound healing essentials: Let there be oxygen

Sen

2009

Wound Repair Regeneration

569

505

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The state of wound oxygenation is a key determinant of healing outcomes. From a diagnostic standpoint, measurements of wound oxygenation are commonly used to guide treatment planning such as amputation decision. In preventive applications, optimizing wound perfusion and providing supplemental O2 in the perioperative period reduces the incidence of postoperative infections. Correction of wound pO2 may, by itself, trigger some healing responses. Importantly, approaches to correct wound pO2 favorably influence outcomes of other therapies such as responsiveness to growth factors and acceptance of grafts. Chronic ischemic wounds are essentially hypoxic. Primarily based on the tumor literature, hypoxia is generally viewed as being angiogenic. This is true with the condition that hypoxia be acute and mild to modest in magnitude. Extreme near‐anoxic hypoxia, as commonly noted in problem wounds, is not compatible with tissue repair. Adequate wound tissue oxygenation is required but may not be sufficient to favorably influence healing outcomes. Success in wound care may be improved by a personalized health care approach. The key lies in our ability to specifically identify the key limitations of a given wound and in developing a multifaceted strategy to specifically address those limitations. In considering approaches to oxygenate the wound tissue it is important to recognize that both too little as well as too much may impede the healing process. Oxygen dosing based on the specific need of a wound therefore seems prudent. Therapeutic approaches targeting the oxygen sensing and redox signaling pathways are promising.

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Section: Tissue Oxygenation and Wound Therapymentioning

confidence: 99%

Wound healing essentials: Let there be oxygen

Sen

2009

Wound Repair Regeneration

569

505

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“…Mitochondria are the major endogenous source of ROS as a natural cost of a 2% inefficiency of uncontrolled electrons that leak and encounter O 2 to form O 2 Ϫ• (60). Low levels of ROS are important for many life-sustaining processes of cells and tissues (95,261), but they induce cell damage and death at higher levels. In normal aging, ROS production increases, whereas the antioxidant capacity fails to increase sufficiently (163,208).…”

Section: Ros Production and Oxidative Stressmentioning

confidence: 99%

Mitoenergetic failure in Alzheimer disease

Parihar

Brewer

2007

American Journal of Physiology-Cell Physiology

135

105

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Brain cells are highly energy dependent for maintaining ion homeostasis during high metabolic activity. During active periods, full mitochondrial function is essential to generate ATP from electrons that originate with the oxidation of NADH. Decreasing brain metabolism is a significant cause of cognitive abnormalities of Alzheimer disease (AD), but it remains uncertain whether this is the cause of further pathology or whether synaptic loss results in a lower energy demand. Synapses are the first to show pathological symptoms in AD before the onset of clinical symptoms. Because synaptic function has high energy demands, interruption in mitochondrial energy supply could be the major factor in synaptic failure in AD. A newly discovered age-related decline in neuronal NADH and redox ratio may jeopardize this function. Mitochondrial dehydrogenases and several mutations affecting energy transfer are frequently altered in aging and AD. Thus, with the accumulation of genetic defects in mitochondria at the level of energy transfer, the issue of neuronal susceptibility to damage as a function of age and age-related disease becomes important. In an aging rat neuron model, mitochondria are both chronically depolarized and produce more reactive oxygen species with age. These concepts suggest that multiple treatment targets may be needed to reverse this multifactorial disease. This review summarizes new insights based on the interaction of mitoenergetic failure, glutamate excitotoxicity, and amyloid toxicity in the exacerbation of AD.

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“…However, if oxygen is applied directly to the hypoxic wound, the rapid consumption or overdoses of oxygen will produce a plethora of adverse superoxide radicals to trigger cell cycle arrest and epigenetic modifications. [ 28 ] Therefore, constructing an oxygen reservoir in the dressing on the wound bed is desirable, which can store wound‐friendly dissolved oxygen that is more amenable to be applied to the hypoxic wound area at any time in a continuous and long‐lasting flow. Herein, a supramolecular self‐assembled GUF hydrogel that acts as oxygen collecting and delivering reservoir was prepared by combining the FHBP and modified gelatin ( Figure A).…”

Section: Resultsmentioning

confidence: 99%

A Programmable Oxygenation Device Facilitates Oxygen Generation and Replenishment to Promote Wound Healing

Yang,

Jin,

Liu

et al. 2023

Advanced Materials

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Inadequate oxygenation is one of the chief culprits for delayed wound healing. However, current oxygen therapies, such as hyperbaric oxygen therapy and topical oxygen therapy, face hurdles in providing sustained and long‐term oxygenation to reverse wound hypoxia. Furthermore, their efficacy in rejuvenating wound injury is restricted by limited penetration of oxygen in the wound bed. Herein, this study proposes a programmable and portable oxygenation device (named GUFO oxydevice) by ingeniously integrating (i) a controllable oxygen generation and unidirectional transmission system (COGT‐UTS), and (ii) a supramolecular assembled perfluorinated hyperbranched polymer/gelatin (GUF) hydrogel in which the perfluorinated hyperbranched polymer (FHBP) acts as an oxygen reservoir to ensure sustained and convenient oxygen replenishment and thus directly regulate the hypoxic wound microenvironment. Accelerating the wound healing process by GUFO oxydevice was achieved in both a diabetic rat and an acute porcine wound model without any secondary tissue damages. The present study demonstrates that the GUFO oxydevice holds promise as a practically feasible candidate for wound treatment.This article is protected by copyright. All rights reserved

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Reactive oxygen species and related haem pathway components as possible epigenetic modifiers in neurobehavioural pathology

Cited by 10 publications

References 81 publications

Wound healing essentials: Let there be oxygen

Wound healing essentials: Let there be oxygen

Mitoenergetic failure in Alzheimer disease

A Programmable Oxygenation Device Facilitates Oxygen Generation and Replenishment to Promote Wound Healing

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