Reactive oxygen species and cancer paradox: To promote or to suppress?

Galadari, Sehamuddin; Rahman, Anees; Pallichankandy, Siraj; Thayyullathil, Faisal

doi:10.1016/j.freeradbiomed.2017.01.004

Cited by 764 publications

(615 citation statements)

References 416 publications

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“…In agreement, overexpression of the antioxidant SOD3 inhibits murine breast cancer cell metastasis (38), and the ROS scavenger N-acetyl-cysteine reduces the tumorigenicity of murine melanoma cells (15). High endogenous ROS concentrations in malignant cells may also render these cells more vulnerable to further stresses (34,39,40). Hence, anticancer therapies that trigger a further increase in ROS formation may induce cell death in cancer cells compared with their non-malignant counterparts (34,41,42).…”

Section: Gr1mentioning

confidence: 88%

“…Cancer cells, thus, display elevated ROS concentrations due to enhanced metabolism and mutations that trigger oxidative processes (32)(33)(34). The increased ROS may promote mutagenesis and may also render tumor cells more prone to expand and produce distant metastases (34)(35)(36)(37). In agreement, overexpression of the antioxidant SOD3 inhibits murine breast cancer cell metastasis (38), and the ROS scavenger N-acetyl-cysteine reduces the tumorigenicity of murine melanoma cells (15).…”

Section: Gr1mentioning

confidence: 98%

“…However, several studies report contradictory effects of ROS on the course of experimental melanoma and other forms of cancer, in particular regarding direct effects of ROS on tumor cells. Cancer cells, thus, display elevated ROS concentrations due to enhanced metabolism and mutations that trigger oxidative processes (32)(33)(34). The increased ROS may promote mutagenesis and may also render tumor cells more prone to expand and produce distant metastases (34)(35)(36)(37).…”

Section: Gr1mentioning

confidence: 99%

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Role of NOX2-Derived Reactive Oxygen Species in NK Cell–Mediated Control of Murine Melanoma Metastasis

Aydin

Johansson

Nazir

et al. 2017

Cancer Immunology Research

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The NADPH oxidase of myeloid cells, NOX2, generates reactive oxygen species (ROS) to eliminate pathogens and malignant cells. NOX2-derived ROS have also been proposed to dampen functions of natural killer (NK) cells and other antineoplastic lymphocytes in the microenvironment of established tumors. The mechanisms by which NOX2 and ROS influence the process of distant metastasis have only been partially explored. Here, we utilized genetically NOX2-deficient mice and pharmacologic inhibition of NOX2 to elucidate the role of NOX2 for the hematogenous metastasis of melanoma cells. After intravenous inoculation of B16F1 or B16F10 cells, lung metastasis formation was reduced in B6.129S6-Cybb tm1DinK (Nox2-KO) versus Nox2-sufficient wild-type (WT) mice. Systemic treatment with the NOX2-inhibitor histamine dihydrochloride (HDC) reduced melanoma metastasis and enhanced the infiltration of IFNg-producing NK cells into lungs of WT but not of Nox2-KO mice. IFNg-deficient B6.129S7-Ifng tm1Ts /J mice were prone to develop melanoma metastases and did not respond to in vivo treatment with HDC. We propose that NOX2-derived ROS facilitate metastasis of melanoma cells by downmodulating NK-cell function and that inhibition of NOX2 may restore IFNg-dependent, NK cell-mediated clearance of melanoma cells. Cancer Immunol Res; 5(9); 804-11. Ó2017AACR.

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Section: Gr1mentioning

confidence: 88%

Section: Gr1mentioning

confidence: 98%

Section: Gr1mentioning

confidence: 99%

See 1 more Smart Citation

Role of NOX2-Derived Reactive Oxygen Species in NK Cell–Mediated Control of Murine Melanoma Metastasis

Aydin

Johansson

Nazir

et al. 2017

Cancer Immunology Research

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“…In fact, some investigators have hypothesized that antioxidant supplements have ability to lower the cancer incidence and subside the subsequent chemotherapyinduced reproductive toxicity. They also believe these supplements, by providing protection against toxic side effects, might potentiate chemotherapy and radiation therapy; however some others are even not confident whether reactive oxygen and nitrogen species function to promote or to suppress the cancer (13).…”

Section: Issn 2330-4456mentioning

confidence: 99%

Chemotherapy-Induced Oxidative Stress and Infertility

Najafi¹

2017

International Journal of Women’s Health and Reproduction Scienc

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“…Н 2 О 2 затем реагирует с Fe (II) образуя FeOxH, как посредник в ре-акции Фентона, производя гидроксильные радикалы. Авторы показали, что GO-FeOxH может быть использован в качестве активи-руемого наноагента, обеспечивающего эф-фективную терапию рака [4,7].…”

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Biological and Chemical Effects by Endo- And Exogenous Hydrogen Peroxide in Human Body Cells Structures

Reva¹,

Yamamoto²,

Gulkov³

et al. 2017

IJAFR (МЖПФИ)

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Учитывая возрастающую антибиотикорезистентность микроорганизмов, появление новых устойчивых к антибиотикам штаммов смертельно опасных инфекционных патогенов, поиск альтернативных медицин-ских препаратов приобретает особую актуальность на современном этапе. В работе представлен анализ собственных и данных литературы о роли экзогенного и эндогенного hydrogen peroxide в условиях нормы и патологии, на фоне микробной контаминации и при острой и хронической ишемии тканей. Показано, что наряду с отрицательной ролью внутриклеточного hydrogen peroxide, при парентеральном введении, он оказывает благоприятное лечебное действие при инфекциях, ишемических повреждениях нервной ткани, а также онкологической и эндокринной патологии. Отмечено, что в то время, как наружное применение пре-паратов hydrogen peroxide не вызывает никаких сомнений в необходимости его использования, применение его в качестве внутреннего лечебного препарата требует глубоких исследований вследствие многочислен-ных противоречивых данных. Vladivostok, e-mail: tiltiltil@yandex.ru) Given the increasing antibiotic resistance of microorganisms, the emergence of new antibiotic-resistant strains of deadly infectious pathogens, the search for alternative medicines is the particular relevance at the present stage. The paper presents an analysis of its own data and literature on the role of exogenous and endogenous hydrogen peroxide under normal and pathological conditions, against microbial contamination and acute and chronic tissue ischemia. It is shown that in addition to the negative role endogenous hydrogen peroxide entered in the blood, or parenteral, it has a beneficial and healing effect in infections, ischemic damage to the nervous tissue, as well as oncology and endocrine pathology. It is noted that while the external application of preparations hydrogen peroxide no doubt the necessity of its use, its application as an internal curative preparation requires numerous deep researches conflicting data.

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Reactive oxygen species and cancer paradox: To promote or to suppress?

Cited by 764 publications

References 416 publications

Role of NOX2-Derived Reactive Oxygen Species in NK Cell–Mediated Control of Murine Melanoma Metastasis

Role of NOX2-Derived Reactive Oxygen Species in NK Cell–Mediated Control of Murine Melanoma Metastasis

Chemotherapy-Induced Oxidative Stress and Infertility

Biological and Chemical Effects by Endo- And Exogenous Hydrogen Peroxide in Human Body Cells Structures

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