Reactive oxygen species and bacterial biofilms in diabetic wound healing

Nouvong, Aksone; Ambrus, Aaron M.; Zhang, Ellen R; Hultman, Lucas; Coller, Hilary A.

doi:10.1152/physiolgenomics.00066.2016

Cited by 60 publications

(47 citation statements)

References 103 publications

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“…Intradermal suture may also improve the function of sleep quality (29)(30)(31). Typically, the time taken for wounds to heal in patients without diabetes is decreased compared with patients with diabetes (32)(33)(34)(35). Consistent with these previous studies, it was indicated in the present study that the time taken for wounds to heal in patients with diabetes was increased compared with that of the patients without diabetes in the control group.…”

Section: Discussionsupporting

confidence: 90%

Retrospective observational cohort study on cosmetic outcome of using Ti‑Ni memory alloy wire for intradermal suture following mastectomy in patients with breast cancer

Qin

Sun

et al. 2017

Oncol Lett

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Abstract. The method of suturing for incisions is crucial for the comprehensive treatment of clinical patients with breast cancer. Suturing is considered a major part of post-surgical recovery and may serve as a marker for evaluation of surgical outcome. The present study aimed to establish an effective means of suturing for patients who received modified radical surgery that helps to improve the cosmetic outcome of the incision. Enrolled patients were divided into an active and a control group. Ti-Ni memory alloy wire for intradermal suture in the active group and silk for interruption suture in the control group were applied to assess the different prognosis-associated factors. The Vancouver Scar Scale (VSS) was used to evaluate the wound size and the recovery time of the scars. The association between diabetes and the number of days of wound healing was also analyzed. The results indicated that the mean VSS score of the active group was decreased compared with that of the control group (P<0.001). The VSS scores of four main features (vascularity, pigmentation, pliability and height) between the two groups also statistically differed (P<0.001). Furthermore, the mean number of days of wound healing was significantly decreased for the active group compared with that for the control group (P=0.0026) in the patients with diabetes. In addition, the usage of Ti-Ni memory alloy wire was able to decrease the mean number of wound healing days between patients with diabetes and their non-diabetic counterparts (P=0.7009). The present study indicated that intradermal suture offers improved cosmetic outcome for patients undergoing mastectomy with or without axillary surgery. This technique may be useful for preventing scar overgrowth and for facilitating the recovery process in patients with diabetes. IntroductionIn 1882, Halsted pioneered the radical resection of the breast. Breast surgery methods have changed since and clinicians commonly perform breast-conserving surgery. However, the optimal approach for radical resection remains controversial (1). Along with social progress and improvements in the quality of life, patients with cancer, particularly patients with breast cancer have increasing requirements for the function and cosmetic outcome following surgery (2,3). A previous study identified that 61% of patients reported that the opinions of their partners of the scars were important to them (4). The way an incision is closed and managed post-operatively affects cosmetic outcome (5). Historically, in breast cancer surgery, simultaneously ensuring treatment effect, shrinking excision scope and attending to the cosmetic effect has been important (6). To improve the aesthetic results for female patients undergoing breast cancer surgery, surgical techniques have been developed to render scars less noticeable (7,8).In China, the majority of patients with breast cancer are treated with modified radical surgery using discontinuous silk suture, which leaves a very noticeable scar (9). A study on cosmetic surgery identified ...

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Section: Discussionsupporting

confidence: 90%

Retrospective observational cohort study on cosmetic outcome of using Ti‑Ni memory alloy wire for intradermal suture following mastectomy in patients with breast cancer

Qin

Sun

et al. 2017

Oncol Lett

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“…Hsu et al also reported that high glucose levels encourage the formation of vancomycin-resistant S. aureus biofilms [ 38 ]. Other studies have shown that the host response and neutrophil oxidative burst activity were decreased in the wound, and that oxidative stress and reactive oxygen species promoted biofilm appearance [ 39 , 40 ]. James et al suggested that biofilms in wounds induced oxygen-limiting conditions (and thus stress) by the following two mechanisms: (i) bacterial metabolic activities and (ii) oxygen-deprivation by the host defenses [ 41 ].…”

Section: Overview Of Biofilms In Dfumentioning

confidence: 99%

Biofilms in Diabetic Foot Ulcers: Significance and Clinical Relevance

et al. 2020

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Foot infections are the main disabling complication in patients with diabetes mellitus. These infections can lead to lower-limb amputation, increasing mortality and decreasing the quality of life. Biofilm formation is an important pathophysiology step in diabetic foot ulcers (DFU)—it plays a main role in the disease progression and chronicity of the lesion, the development of antibiotic resistance, and makes wound healing difficult to treat. The main problem is the difficulty in distinguishing between infection and colonization in DFU. The bacteria present in DFU are organized into functionally equivalent pathogroups that allow for close interactions between the bacteria within the biofilm. Consequently, some bacterial species that alone would be considered non-pathogenic, or incapable of maintaining a chronic infection, could co-aggregate symbiotically in a pathogenic biofilm and act synergistically to cause a chronic infection. In this review, we discuss current knowledge on biofilm formation, its presence in DFU, how the diabetic environment affects biofilm formation and its regulation, and the clinical implications.

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“…Furthermore, ROS/oxidative stress/mitochondrial dysfunction and inflammation behave as an indissoluble, interconnected nosogenic unit that links organismal aging, T2DM, and poor wound healing (73,(154)(155)(156)(157)(158). Converging evidences demonstrate that high levels of ROS disrupt the normal healing process (159)(160)(161) and constitute a hallmark in chronic wounds including recalcitrant DFU (147,159,162). In this scenario ROS overproduction is associated to the upregulation of cell cycle inhibitors as to positivity for the SA-β gal marker.…”

Section: The Senescence Messenger Organ Metabolic Derangements and mentioning

confidence: 99%

Cellular Senescence as the Pathogenic Hub of Diabetes-Related Wound Chronicity

et al. 2020

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Diabetes is constantly increasing at a rate that outpaces genetic variation and approaches to pandemic magnitude. Skin cells physiology and the cutaneous healing response are progressively undermined in diabetes which predisposes to lower limb ulceration, recidivism, and subsequent lower extremities amputation as a frightened complication. The molecular operators whereby diabetes reduces tissues resilience and hampers the repair mechanisms remain elusive. We have accrued the notion that diabetic environment embraces preconditioning factors that definitively propel premature cellular senescence, and that ulcer cells senescence impair the healing response. Hyperglycemia/oxidative stress/mitochondrial and DNA damage may act as major drivers sculpturing the senescent phenotype. We review here historical and recent evidences that substantiate the hypothesis that diabetic foot ulcers healing trajectory, is definitively impinged by a self-expanding and self-perpetuative senescent cells society that drives wound chronicity. This society may be fostered by a diabetic archetypal secretome that induces replicative senescence in dermal fibroblasts, endothelial cells, and keratinocytes. Mesenchymal stem cells are also susceptible to major diabetic senescence drivers, which accounts for the inability of these cells to appropriately assist in diabetics wound healing. Thus, the use of autologous stem cells has not translated in significant clinical outcomes. Novel and multifaceted therapeutic approaches are required to pharmacologically mitigate the diabetic cellular senescence operators and reduce the secondary multi-organs complications. The senescent cells society and its adjunctive secretome could be an ideal local target to manipulate diabetic ulcers and prevent wound chronification and acute recidivism. This futuristic goal demands harnessing the diabetic wound chronicity epigenomic signature.

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Reactive oxygen species and bacterial biofilms in diabetic wound healing

Cited by 60 publications

References 103 publications

Retrospective observational cohort study on cosmetic outcome of using Ti‑Ni memory alloy wire for intradermal suture following mastectomy in patients with breast cancer

Retrospective observational cohort study on cosmetic outcome of using Ti‑Ni memory alloy wire for intradermal suture following mastectomy in patients with breast cancer

Biofilms in Diabetic Foot Ulcers: Significance and Clinical Relevance

Cellular Senescence as the Pathogenic Hub of Diabetes-Related Wound Chronicity

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