Reactive oxygen nano-generators for cancer therapy

Kalyane, Dnyaneshwar; Choudhary, Devendra; Polaka, Suryanarayana; Goykar, Hanmant; Karanwad, Tukaram; Rajpoot, Kuldeep; Tekade, Rakesh K.

doi:10.1016/j.pmatsci.2022.100974

Cited by 30 publications

(8 citation statements)

References 323 publications

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“…In view of the catalytic reaction mechanisms of carbon-based nanoenzymes remaining unclear, in-depth research was carried out on N/S-HCS mimic oxidase. It should be primarily concerned with the formation of reactive oxygen species (ROS) and O 2 in the system, , to determine whether the dissolved oxygen in the system affects the N/S-HCS oxidase-like catalytic process. The colorimetric reaction is evidently increased in an O 2 -saturated atmosphere (Figure a), and suppressed in a N 2 atm, demonstrating that the oxidase-like activity was dynamically correlated with the concentration of dissolved oxygen molecules.…”

Section: Resultsmentioning

confidence: 99%

N-Rich and Sulfur-Doped Nano Hollow Carbons with High Oxidase-like Activity Prepared Using a Green Template of CaCO₃ for Bacteriostasis

Liu,

Deng,

Wang

et al. 2023

Langmuir

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Nanozymes, enzyme-mimicking nanomaterials, have attracted increasing attention due to their low cost, high stability, and catalytic ability compared with natural enzymes. However, the catalytic efficiency of the nanozymes is still relatively low, and catalytic reaction mechanisms remain unclear. To address these issues, herein we prepared nitrogen-riched and sulfur-codoped nano hollow carbons (N/S-HCS) using a green and useful template of CaCO 3 . N/S-HCS exhibits enhanced oxidase-like activity and catalytic kinetic performance. It could directly oxidize the colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to the heavy blue colored ox-TMB without H 2 O 2 . The maximum reaction rate (V max ) is 186.7 × 10 −8 M•s −1 , and Michaelis−Menten constant (K m ) is 0.162 mM. DFT results show that N and S codoping could work synergistically to provide more active sites, resulting in the superior ability to adsorb oxygen and enhanced catalytic activity. Meantime, we develop a multispectral characterization strategy to unravel catalytic reaction mechanisms about N/S-HCS. It successfully induces the generation of superoxide ( • O 2 − ) and hydroxyl ( • OH) during the colorimetric reaction which are the key intermediate products of the catalytic reaction. Furthermore, N/S-HCS increased the cellular reactive oxygen species level significantly and induced bacteriostasis to more than 95% of Escherichia coli.

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Section: Resultsmentioning

confidence: 99%

N-Rich and Sulfur-Doped Nano Hollow Carbons with High Oxidase-like Activity Prepared Using a Green Template of CaCO₃ for Bacteriostasis

Liu,

Deng,

Wang

et al. 2023

Langmuir

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“…It is reported that photothermal therapy promotes excessive ROS generation, leading to cancer cell death (16,33). Our study found that AuraTherm significantly promotes ROS generation upon 808 NIR laser irradiation in MDA‐MB‐231 cells (Fig.…”

Section: Resultsmentioning

confidence: 99%

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Kalyane

Polaka

Vasdev

et al. 2022

Photochem & Photobiology

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This investigation reports the quality‐by‐design (QbD) assisted novel templated approach for developing cancer cell‐specific and laser‐activatable nanoseeds (AuraTherm) for targeted photothermal ablation of triple‐negative breast cancer (TNBC). AuraTherm was nanometric in size as characterized by SEM, TEM and particle analysis (80.28 ± 2.56 nm; −21.80 ± 0.17 mV) with hemocompatibility and neutrality towards blood components. AuraTherm showed reversible photothermal effect (ΔT: 37 ± 1.2°C → 49.4 ± 1.5°C; 15 min; 2.4 W cm−2) employing near‐infrared 808 nm laser (NIR‐808). The targeted cytosolic localization led to a significant anticancer activity as evaluated using apoptosis assay, cell cycle analysis, Intracellular ROS generation assay, cellular uptake and receptor binding assay. The NIR‐808 laser‐responsive photothermal ablation of cancer cell was found to be more effective compared to without NIR‐808 laser‐treated counterparts, suggesting the fundamental role of photothermal ablation in the treatment of TNBC.

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“…An oxidatively stressed environment will alter the protein functions and prevent the proper relay of the calcium signal in CAT-downregulated cancerous cells, resulting in unrestrained Ca 2+ build-up and cell death [167,168]. Similarly, nanosystems which used CaO 2 as an oxygen source and hematoporphyrin monomethyl as a photosensitizer have been synthesized and reported [169,170]. Tis approach efectively coupled photodynamic therapy with calcium overload.…”

Section: Targeting Metal Ion Homeostasismentioning

confidence: 99%

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Mbugua

2022

Bioinorganic Chemistry and Applications

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Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen-dependent treatments such as photodynamic therapy and radiotherapy fail to respond and therefore modulating the hypoxic tumor microenvironment has been found to enhance the antitumor impact of certain drugs. Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxides with water not only induces oxidative stress but also produces additional oxygen. This is achieved since hydrogen peroxide acts as a reactive substrate for molecules such as catalyse enzymes, alleviating tumor hypoxia observed in the tumor microenvironment. Metal ions released in the process can also offer distinct bioactivity in their own right. Metal peroxides used in anticancer therapy are a rapidly evolving field, and there is good evidence that they are a good option for regulating the tumor microenvironment in cancer therapy. In this regard, the synthesis and mechanisms behind the successful application of metal peroxides to specifically target the tumor microenvironment are highlighted in this review. Various characteristics of TME such as angiogenesis, inflammation, hypoxia, acidity levels, and metal ion homeostasis are addressed in this regard, together with certain forms of synergistic combination treatments.

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Reactive oxygen nano-generators for cancer therapy

Cited by 30 publications

References 323 publications

N-Rich and Sulfur-Doped Nano Hollow Carbons with High Oxidase-like Activity Prepared Using a Green Template of CaCO₃ for Bacteriostasis

N-Rich and Sulfur-Doped Nano Hollow Carbons with High Oxidase-like Activity Prepared Using a Green Template of CaCO₃ for Bacteriostasis

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

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Reactive oxygen nano-generators for cancer therapy

Cited by 30 publications

References 323 publications

N-Rich and Sulfur-Doped Nano Hollow Carbons with High Oxidase-like Activity Prepared Using a Green Template of CaCO3 for Bacteriostasis

N-Rich and Sulfur-Doped Nano Hollow Carbons with High Oxidase-like Activity Prepared Using a Green Template of CaCO3 for Bacteriostasis

Cancer Cell‐Specific and Laser‐Activatable NanoSeeds for Targeted Photothermal Ablation of Triple‐Negative Breast Cancer

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

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Product

Resources

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N-Rich and Sulfur-Doped Nano Hollow Carbons with High Oxidase-like Activity Prepared Using a Green Template of CaCO₃ for Bacteriostasis

N-Rich and Sulfur-Doped Nano Hollow Carbons with High Oxidase-like Activity Prepared Using a Green Template of CaCO₃ for Bacteriostasis