Reactive Oxygen Metabolites: A Link between Oxidative Stress and Inflammation in Patients on Hemodialysis

Samouilidou, Elisabeth; Grapsa, Eirini; Karpouza, A.; Lagouranis, Antonios

doi:10.1159/000098521

Cited by 19 publications

(11 citation statements)

References 42 publications

(24 reference statements)

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“…A decrease in this enzyme activity might lead to an enhancement of lipid peroxidation chain reactions and to an increase in the inflammatory response. Indeed, the association between inflammation and oxidative stress in HD was examined in our previous report by means of other markers of oxidative stress and lipid peroxidation [32]. In the present study, it was reconfirmed by the significant oxLDL and CRP correlation underlying the role of inflammation in the development of oxidative stress.…”

Section: Discussionsupporting

confidence: 79%

Serum Oxidized LDL Is Inversely Associated with HDL2-Cholesterol Subclass in Renal Failure Patients on Hemodialysis

Samouilidou

Karpouza²,

Grapsa³

et al. 2010

Nephron Clin Pract

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Background:Dyslipoproteinemia and oxidative modification of LDL (oxLDL) are common symptoms in patients suffering from chronic renal failure on hemodialysis (HD), and contribute to the development of oxidative stress. High-density lipoprotein cholesterol (HDL-C) protects against atherosclerosis by inhibiting the oxidation of lipoproteins and by supporting reverse cholesterol transport. This study intends to examine the association of oxLDL with HDL2 and HDL3 subclasses of HDL-C in HD patients, in order to elucidate whether oxidative stress influences HDL-C composition. Methods: Thirty-four patients on HD and 21 age- and sex-matched controls were studied. HDL2 and HDL3-C subclasses were isolated from serum according to a single-step precipitation method following a homogenous HDL-C assay. oxLDL was measured by ELISA. Results: In HD patients, oxLDL concentration was higher compared to the controls (1.40 ± 0.47 vs. 0.21 ± 0.05 mg/l, p = 0.017) and was significantly associated to total cholesterol (r = 0.480, p = 0.044), LDL-C (r = 0.544, p = 0.019), HDL-C (r = –0.589, p = 0.027) and C-reactive protein (r = 0.578, p = 0.024). Comparing HDL-C subclasses, only HDL2-C was negatively correlated to oxLDL levels (r = –0.565, p = 0.035). Conclusions: In HD patients, high serum levels of oxLDL are associated with low HDL2-C subclass levels. This might suggest that oxidative stress affects the HDL subclass more related to the protecting activity of HDL-C, contributing to atherosclerosis development.

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Section: Discussionsupporting

confidence: 79%

Serum Oxidized LDL Is Inversely Associated with HDL2-Cholesterol Subclass in Renal Failure Patients on Hemodialysis

Samouilidou

Karpouza²,

Grapsa³

et al. 2010

Nephron Clin Pract

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“…Several reports have shown a positive correlation between serum ROM and hsCRP levels in patients with coronary artery disease 28) and those undergoing hemodialysis 29,30) . To our knowledge, however, there has been only one report 31) on the general population.…”

Section: Discussionmentioning

confidence: 99%

Relations between Serum Reactive Oxygen Metabolites (ROMs) and Various Inflammatory and Metabolic Parameters in a Japanese Population

Hara

Kawabe

Komiya

et al. 2009

JAT

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Aim: Both oxidative stress and inflammation are known to play roles in the pathogenesis of cardiovascular disease. We investigated the relations between reactive oxygen metabolites (ROMs) and various inflammatory and metabolic parameters in a Japanese population. Methods: We analyzed 48 male and 69 female subjects, aged 25 to 65 years, who underwent an annual health checkup in our university. Serum ROM level was assayed using a free radical elective evaluator. We also measured serum concentrations of high-sensitivity C-reactive protein (hsCRP), insulin, and high molecular weight (HMW) adiponectin. Results: Although the serum ROM level in females (347 83 Carr U) was slightly higher than in males (333 53 Carr U), this was not statistically significant. In the 48 male subjects, the ROM level

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“…In the literature there are reports on OS [16] and HLA-DR expression [17] in chronic kidney disease patients, but data on septic ICU patients with AKI requiring CRRT are lacking. Our aim was to evaluate whether increased OS and low monocyte HLA-DR expression are associated with outcome in this specific group of patients.…”

mentioning

confidence: 99%

Oxidative Stress and ‘Monocyte Reprogramming’ in Septic Patients with Acute Kidney Injury Requiring CRRT

Silva¹,

Cal²,

Cruz³

et al. 2008

Blood Purif

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Oxidative stress (OS) and monocyte HLA-DR expression are known to be predictive of mortality in sepsis; nevertheless, limited information exists regarding sepsis with acute kidney injury (AKI). The aim of the study was to correlate these markers with outcome in septic patients with AKI requiring continuous renal replacement therapy (CRRT). Advanced oxidation protein products (AOPP) were measured in 32 patients on days 1, 3, 7, 14, 21, and 28. In 14 we assessed the percentage of monocytes expressing HLA-DR (%DR+) and the HLA-DR mean fluorescence intensity (MFI). 20 healthy volunteers, 17 septic patients without AKI and 20 septic AKI patients not treated by CRRT were used for comparison. The mortality rate was 59%. Septic CRRT patients had higher AOPP and lower %DR+ (p < 0.001, both) than healthy controls. They also had higher AOPP than septic patients who did not develop AKI (p < 0.001). No difference was found in AOPP, %DR+ and MFI between survivors and non-survivors (day 1 and subsequent measurements). No correlation was seen between severity scores and OS/HLA-DR. OS and HLA-DR expression are altered in septic patients with AKI undergoing CRRT. However, this study was not able to confirm the usefulness of these markers in predicting survival in this subset of patients.

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Reactive Oxygen Metabolites: A Link between Oxidative Stress and Inflammation in Patients on Hemodialysis

Cited by 19 publications

References 42 publications

Serum Oxidized LDL Is Inversely Associated with HDL2-Cholesterol Subclass in Renal Failure Patients on Hemodialysis

Serum Oxidized LDL Is Inversely Associated with HDL2-Cholesterol Subclass in Renal Failure Patients on Hemodialysis

Relations between Serum Reactive Oxygen Metabolites (ROMs) and Various Inflammatory and Metabolic Parameters in a Japanese Population

Oxidative Stress and ‘Monocyte Reprogramming’ in Septic Patients with Acute Kidney Injury Requiring CRRT

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