Reactive microglia fail to respond to environmental damage signals in a viral-induced mouse model of temporal lobe epilepsy
Glenna J. Wallis,
Laura A. Bell,
John N. Wagner
et al.
Abstract:Microglia are highly adaptable innate immune cells that rapidly respond to damage signals in the brain through adoption of a reactive phenotype and production of defensive inflammatory cytokines. Microglia express a distinct transcriptome, encoding receptors that allow them to dynamically respond to pathogens, damage signals, and cellular debris. Expression of one such receptor, the microglia-specific purinergic receptor P2ry12, is known to be downregulated in reactive microglia. Here, we explore the microglia… Show more
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