Reactive lymphoid hyperplasia of the liver

Moon, Woo Sung; Choi, Keum Ha

doi:10.3350/cmh.2013.19.1.87

Cited by 14 publications

(9 citation statements)

References 15 publications

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“…First reported by Snover et al, reactive lymphoid hyperplasia has been reported in many organs in the body and rarely in the liver [ 6 , 7 ]. More than 50 cases have been described in the English literature since then, with a predilection to middle-aged women (female : male ratio is 8 : 1), with some types of autoimmune disease in about 40% of the cases [ 8 ]. Most patients were in their 6th decade of life with an average age at diagnosis of 55 years.…”

Section: Discussionmentioning

confidence: 99%

Intrahepatic Reactive Lymphoid Hyperplasia: A Case Report and Review of the Literature

Seitter

Goodman

Friedman

et al. 2018

Case Reports in Surgery

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Introduction Reactive lymphoid hyperplasia (RLH) is a rare and benign lesion found in organs of the gastrointestinal tract, skin, lung, orbit, and more rarely in the liver. Due to its similar appearance on imaging, it is hard to differentiate from primary liver malignancies. The following is a case report of a patient presenting with a suspicious liver lesion found to be RLH associated with primary biliary cirrhosis (PBC), after surgical resection. Presentation of Case A 54-year-old woman presented with nonspecific abdominal pain, and her workup included axial imaging of the abdomen that showed a suspicious lesion in her liver. After an extensive workup, which included a percutaneous biopsy, failed to confirm a diagnosis, a laparoscopic surgical resection was recommended. Discussion RLH is a rare condition of the liver, presenting in a suspicious fashion and raising concerns for a primary liver malignancy. RLH should be considered in the differential diagnosis of small hepatic lesions in middle-age females in the absence of any significant risk factors for hepatocellular carcinoma (HCC). RLH tends to be associated with PBC of the liver. Conclusion RLH of the liver is a rare, hard to diagnose, benign lesion. When intrahepatic, it cannot be easily differentiated from primary liver tumors and frequently requires surgical resection for pathological diagnostic confirmation.

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Section: Discussionmentioning

confidence: 99%

Intrahepatic Reactive Lymphoid Hyperplasia: A Case Report and Review of the Literature

Seitter

Goodman

Friedman

et al. 2018

Case Reports in Surgery

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“…Of the 51 cases, 5 (9.8 %) involved male patients and 46 involved female patients (90.2 %). Among the 51 cases, 14 (27.4 %) had malignant diseases, including gastric cancer [ 14 – 17 ], colon cancer [ 2 , 18 , 19 ], uterine/ovarian cancer [ 20 ], renal cell carcinoma [ 21 , 22 ], pancreatic cancer [ 17 ], common bile duct cancer [ 23 ], and HCC [ 24 ]. Therefore, the pathogenesis of pseudolymphoma of the liver with an associated malignant tumor may be related to an immunological abnormality caused by the malignant tumor itself.…”

Section: Case Presentationmentioning

confidence: 99%

Pseudolymphoma of the liver: a case report and literature review

et al. 2015

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Pseudolymphoma is a benign lymphocytic tumor-like lesion, and its occurrence in the liver is rare. Here, we report the case of a 78-year-old woman with pseudolymphoma of the liver. She had a history of tremors for several years. Therefore, she underwent computed tomography (CT) for screening, and liver tumors were incidentally identified. She did not have any history of liver disease. Liver function test results and tumor marker levels were all within normal limits, and viral markers for hepatitis were negative. Contrast-enhanced CT revealed four nodules measuring up to 13 mm in diameter with ring enhancement in both lobes of the liver. On magnetic resonance imaging, the lesions showed slightly high intensity on T2-weighted images and high intensity on diffusion-weighted images. Because of atypical imaging findings, the tumors could not be definitively diagnosed. Therefore, we performed laparoscopic limited resection of segments 2, 3, 4, and 8 of the liver. The final pathological diagnosis was pseudolymphoma of the liver. The patient has had no signs of recurrence for 6 months after the surgery. Although pseudolymphoma of the liver is rare, it is necessary to consider it in the differential diagnosis of a liver tumor.

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“…RLH is considered to be a reactive immunological response which may occur in association with malignancy and hepatitis (1)(2)(3)(4). Recognition of this rare lesion is essential in order to avoid unnecessary extended surgical resection.…”

Section: Hepatic Mass With Lymphadenopathy In a B Viral Hepatitis Patmentioning

confidence: 99%

“…RLH is a rare benign condition which forms a mass‐like lesion characterized by proliferation of non‐neoplastic lymphoid cells, which form follicles and germinal centres . RLH is considered to be a reactive immunological response which may occur in association with malignancy and hepatitis . Recognition of this rare lesion is essential in order to avoid unnecessary extended surgical resection.…”

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confidence: 99%