Reactive lymphoid hyperplasia of the liver: A case report and review of imaging characteristics

Tuckett, John; Hudson, Mark; White, Steven A.; Scott, J. E.

doi:10.1016/j.ejrex.2011.04.002

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…In addition, HCC is always accompanied by hepatitis virus infection and elevated level of AFP in China, which can be added to differential clues. From all the cases, we conclude the following radiological clues to help to diagnose hepatic RLH: (a) well-defined hypoechoic mass on the US images [ 4 – 7 , 9 – 12 , 14 , 17 – 19 , 23 , 24 , 32 – 34 ]; (b) low-density lesion in plain CT phase, mild enhancement in the arterial phase, hypodense areas in the portal phase [ 1 – 7 , 9 , 10 , 12 – 18 , 23 , 24 ]; (c) hypointense signal on MRI T1-weighted imaging, hyperintense signal on T2-weighted imaging, moderately enhanced in the arterial phase, hypodense areas in the portal phase and unclear in the delayed phase [ 2 , 3 , 6 , 10 – 15 , 17 , 18 , 24 ]; (d) hypervascularity on angiography [ 11 ]. Preoperative imaging findings of the lesions of all the cases are listed in Table 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Up to now, there have been only scattered case reports about hepatic RLH [1–24]; the paucity of information about its clinicopathological features poses diagnostic and management dilemmas. Manifested as a focal liver mass, hepatic RLH may mimic a malignant liver tumor, often giving rise to misdiagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…Reactive lymphoid hyperplasia (RLH), also termed as nodular lymphoid lesion [ 1 , 2 ] or pseudolymphoma [ 3 – 8 ], is a rare benign condition which forms a liver mass typically infiltrated by massive heterogeneous mature lymphoid cells without prominent nuclear atypia, with formation of follicles and germinal centers. Up to now, there have been only scattered case reports about hepatic RLH [ 1 – 24 ]; the paucity of information about its clinicopathological features poses diagnostic and management dilemmas. Manifested as a focal liver mass, hepatic RLH may mimic a malignant liver tumor, often giving rise to misdiagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Reactive Lymphoid Hyperplasia of the Liver: A Clinicopathological Study of 7 Cases

et al. 2012

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Background. Reactive lymphoid hyperplasia (RLH) of the liver is a benign focal liver mass that may mimic a malignant liver tumor. Although rarely encountered in clinical practice, it often poses diagnostic and management dilemmas. Methods. Cases diagnosed as hepatic RLH between January 1996 and June 2011 were investigated in a retrospective study. Clinicopathological features as well as follow-up information of the cases were studied. Results. A total of seven cases of hepatic RLH were investigated, with a median age of 46 years (range: 33–76 years). Hepatic RLH was accompanied by concomitant diseases in some patients. The average size of hepatic lesions of our cases was 45 mm (range: 15–105 mm). All of the cases were not accurately diagnosed until confirmed by pathological findings, and surgical resections were performed for all. Postoperative course was uneventful for all of the patients during followup. Conclusions. RLH of the liver is a rare benign disease with a female predilection of unknown etiology. It is very difficult to correctly diagnose this disease without pathological results. Subtle differences on radiological findings of it may be helpful for differential diagnosis from other diseases. Curative resection of the lesion is suggested for the treatment of this disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reactive Lymphoid Hyperplasia of the Liver: A Clinicopathological Study of 7 Cases

et al. 2012

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“…Another significant difference is that 90% of HRLH lesions show rim enhancement at the beginning of washout when only 33.3% of PHL lesions have this sign. Many studies have also reported perinodular enhancement of HRLH on contrast-enhanced CT and MRI [9,[26][27][28]. There are some pathological hypotheses about this manifestation.…”

Section: Discussionmentioning

confidence: 99%

Hepatic Reactive Lymphoid Hyperplasia and Primary Hepatic Lymphoma: Ultrasound Features and Differentiation Diagnosis

Qiao¹,

Chen²,

Chen³

et al. 2021

Advanced Ultrasound in Diagnosis and Therapy

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To investigate the ultrasound features of hepatic reactive lymphoid hyperplasia (HRLH) and primary hepatic lymphoma (PHL), and determine the value of ultrasound on the diagnosis and differentiation of them. Methods:The ultrasound findings of 11 HRLH lesions and 14 PHL lesions from April 2011 to September 2020 were retrospectively analyzed. The conventional ultrasound and contrast-enhanced ultrasound (CEUS) manifestations of them were compared.Results: HRLH showed significant female preference than PHL (100% and 64.3%) (P = 0.046). There were no significant differences of other demographics between HRLH and PHL patients. On conventional ultrasound, the diameter of HRLH (16.5 ± 3.8 mm) was significantly smaller than that of PHL (48.3 ± 36.2 mm) (P = 0.008), and a regular shape was seen more frequently in HRLH (90.9%) than that in PHL (50%) (P = 0.038). There were no significant differences of other indexes between HRLH and PHL. On CEUS, both HRLH and PHL presented arterial enhancement and washout in early portal phase. But rim enhancement at the beginning of washout was seen more frequently in HRLH (90.0%) than that in PHL (33.3%) (P = 0.036), and HRLH usually displayed hyperenhancement (100%) in arterial phase while PHL could be hypoenhancement (16.7%), isoenhancement (33.3%) and hyperenhancement (50%) (P = 0.036). Conclusion:Ultrasound can supply valuable imaging evidences for the diagnosis of HRLH and PHL. The ultrasound features including size, shape, degree of arterial phase enhancement and rim enhancement at the beginning of washout can be used for the differentiation of HRLH and PHL.

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Lymphoid Hyperplasia and Pseudolymphomas of the Hepatobiliary Tract

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Reactive lymphoid hyperplasia of the liver: A case report and review of imaging characteristics

Cited by 6 publications

References 18 publications

Reactive Lymphoid Hyperplasia of the Liver: A Clinicopathological Study of 7 Cases

Reactive Lymphoid Hyperplasia of the Liver: A Clinicopathological Study of 7 Cases

Hepatic Reactive Lymphoid Hyperplasia and Primary Hepatic Lymphoma: Ultrasound Features and Differentiation Diagnosis

Lymphoid Hyperplasia and Pseudolymphomas of the Hepatobiliary Tract

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