Reactive lymphoid hyperplasia of liver mimicking late ovarian cancer recurrence: case report and literature review

Marchetti, Cláudia; Manci, Natalina; Maurizio, Marco Di; Tucci, Chiara Di; Burratti, Moira; Iuliano, Marialetizia; Giorgini, Margherita; Salerno, Laura; Panici, Pierluigi Benedetti

doi:10.1007/s10147-011-0191-9

Cited by 20 publications

(6 citation statements)

References 10 publications

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“…As more cases have been described, a correlation with various autoimmune diseases, viral hepatitis, and other concomitant cancers has become evident [ 8 ]. Autoimmune thyroiditis, primary biliary cirrhosis, Sjögren's syndrome, and other immunodeficiencies were found in patients with RLH, in addition to primary malignancies of the stomach, colon, kidneys, and ovaries [ 8 , 10 – 12 ].…”

Section: Discussionmentioning

confidence: 99%

Intrahepatic Reactive Lymphoid Hyperplasia: A Case Report and Review of the Literature

Seitter

Goodman

Friedman

et al. 2018

Case Reports in Surgery

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Introduction Reactive lymphoid hyperplasia (RLH) is a rare and benign lesion found in organs of the gastrointestinal tract, skin, lung, orbit, and more rarely in the liver. Due to its similar appearance on imaging, it is hard to differentiate from primary liver malignancies. The following is a case report of a patient presenting with a suspicious liver lesion found to be RLH associated with primary biliary cirrhosis (PBC), after surgical resection. Presentation of Case A 54-year-old woman presented with nonspecific abdominal pain, and her workup included axial imaging of the abdomen that showed a suspicious lesion in her liver. After an extensive workup, which included a percutaneous biopsy, failed to confirm a diagnosis, a laparoscopic surgical resection was recommended. Discussion RLH is a rare condition of the liver, presenting in a suspicious fashion and raising concerns for a primary liver malignancy. RLH should be considered in the differential diagnosis of small hepatic lesions in middle-age females in the absence of any significant risk factors for hepatocellular carcinoma (HCC). RLH tends to be associated with PBC of the liver. Conclusion RLH of the liver is a rare, hard to diagnose, benign lesion. When intrahepatic, it cannot be easily differentiated from primary liver tumors and frequently requires surgical resection for pathological diagnostic confirmation.

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Section: Discussionmentioning

confidence: 99%

Intrahepatic Reactive Lymphoid Hyperplasia: A Case Report and Review of the Literature

Seitter

Goodman

Friedman

et al. 2018

Case Reports in Surgery

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“…Recently, some reports have examined the use of FDG-PET in the diagnosis of hepatic pseudolymphoma. We found 9 cases in which FDG-PET was used to examine patients with hepatic pseudolymphoma, including our own (Table 2 ) [ 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Seven (78%) of 9 cases showed FDG uptake in the tumor, and the median SUV max was 4.3 (range: 3.4–7.2).…”

Section: Discussionmentioning

confidence: 99%

“…The preoperative diagnosis of hepatic pseudolymphoma is difficult because noninvasive radiological examinations such as ultrasonography (US), computed tomography (CT), and magnetic resonance imaging are usually equivocal. Recently, some reports have examined the use of fluorodeoxyglucose positron emission tomography (FDG-PET) in the diagnosis of hepatic pseudolymphoma [ 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. We herein report a case of hepatic pseudolymphoma with FDG uptake on PET and examine the literature.…”

Section: Introductionmentioning

confidence: 99%

Hepatic Pseudolymphoma with Fluorodeoxyglucose Uptake on Positron Emission Tomography

Suzumura

Hatano

Okada

et al. 2017

Case Rep Gastroenterol

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A 69-year-old woman with chronic hepatitis B was admitted to our hospital with a hepatic tumor. The levels of 2 tumor markers, carcinoembryonic antigen and carbohydrate antigen 19-9, were slightly elevated; however, the α-fetoprotein and protein levels induced by vitamin K antagonist II were within the normal limits. Abdominal ultrasonography showed a well-defined peripheral hypoechoic mass that was isoechoic and homogeneous on the inside. Computed tomography showed a poorly enhanced tumor of 13 mm in diameter in the 5th segment of the liver. Fluorodeoxyglucose positron emission tomography showed a slight uptake (maximum standard uptake value 3.4) by the hepatic tumor. These findings suggested cholangiocellular carcinoma, and we performed anterior segmentectomy of the liver. A histopathological examination showed a hepatic pseudolymphoma. The patient’s postoperative course was uneventful, and she remains alive without recurrence 5 months after undergoing surgery. In most cases, hepatic pseudolymphoma is preoperatively diagnosed as a malignant tumor and a definite diagnosis is made after resection. It is therefore necessary to consider hepatic pseudolymphoma as a differential diagnosis in patients with hepatic tumors.

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“…Of the 51 cases, 5 (9.8 %) involved male patients and 46 involved female patients (90.2 %). Among the 51 cases, 14 (27.4 %) had malignant diseases, including gastric cancer [ 14 – 17 ], colon cancer [ 2 , 18 , 19 ], uterine/ovarian cancer [ 20 ], renal cell carcinoma [ 21 , 22 ], pancreatic cancer [ 17 ], common bile duct cancer [ 23 ], and HCC [ 24 ]. Therefore, the pathogenesis of pseudolymphoma of the liver with an associated malignant tumor may be related to an immunological abnormality caused by the malignant tumor itself.…”

Section: Case Presentationmentioning

confidence: 99%

“…Additionally, CD20 positive B cells are predominantly located within the lymphoid follicles, and CD3 positive T cells are predominantly located in the peri and interfollicular areas. However, the lymphocytes within the germinal centers are negative for Bcl-2, indicating the reactive and nonneoplastic nature of the tumor [ 20 ].…”

Section: Case Presentationmentioning

confidence: 99%

Pseudolymphoma of the liver: a case report and literature review

et al. 2015

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Pseudolymphoma is a benign lymphocytic tumor-like lesion, and its occurrence in the liver is rare. Here, we report the case of a 78-year-old woman with pseudolymphoma of the liver. She had a history of tremors for several years. Therefore, she underwent computed tomography (CT) for screening, and liver tumors were incidentally identified. She did not have any history of liver disease. Liver function test results and tumor marker levels were all within normal limits, and viral markers for hepatitis were negative. Contrast-enhanced CT revealed four nodules measuring up to 13 mm in diameter with ring enhancement in both lobes of the liver. On magnetic resonance imaging, the lesions showed slightly high intensity on T2-weighted images and high intensity on diffusion-weighted images. Because of atypical imaging findings, the tumors could not be definitively diagnosed. Therefore, we performed laparoscopic limited resection of segments 2, 3, 4, and 8 of the liver. The final pathological diagnosis was pseudolymphoma of the liver. The patient has had no signs of recurrence for 6 months after the surgery. Although pseudolymphoma of the liver is rare, it is necessary to consider it in the differential diagnosis of a liver tumor.

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Reactive lymphoid hyperplasia of liver mimicking late ovarian cancer recurrence: case report and literature review

Cited by 20 publications

References 10 publications

Intrahepatic Reactive Lymphoid Hyperplasia: A Case Report and Review of the Literature

Intrahepatic Reactive Lymphoid Hyperplasia: A Case Report and Review of the Literature

Hepatic Pseudolymphoma with Fluorodeoxyglucose Uptake on Positron Emission Tomography

Pseudolymphoma of the liver: a case report and literature review

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