Reactive infectious mucocutaneous eruption secondary to SARS-CoV-2

Reactive infectious mucocutaneous eruption triggered by COVID‐19 infection in an adult patient

“…Approximately 11% of patients with COVID‐19 infection have oral involvement, 3 including aphthous‐like lesions, herpetiform lesions and petechiae, as well as red and white plaques. We have found six reported cases of RIME secondary to COVID‐19: five adolescents (ages 14 to 17), 1 , 2 , 4 , 5 and only one adult, a 23‐year‐old woman presenting with recurrent RIME since age 18. Her first episode was triggered by M. pneumoniae , the second by influenza A, and the third by SARS‐CoV‐2.…”

“…Mucocutaneous lesions of RIME appear with a latency of 4 days to 12 weeks after symptoms of COVID‐19 infection. 5 Several pathogenic mechanisms have been proposed, including immune complex deposition, complement activation and molecular mimicry. 1 The treatment for RIME is merely supportive since it is self‐limited, resolving in 1–3 weeks, although corticosteroids have been indicated in severe cases.…”

“… 4 In one non‐responding patient, cyclosporine was successfully prescribed. 5 The recurrence rate of RIME is unknown, but MIRM has been reported to recur in up to 8% of patients.…”

Reactive infectious mucocutaneous eruption following COVID‐19 in an adolescent boy: Case report and review of the literature

“…There have been six reported pediatric cases of RIME induced by SARS‐CoV‐2 infection (Table 1 ). 5 , 6 , 7 , 8 All reported patients were male, ranging from 13 to 17 years old, and all cases were confirmed by SARS‐Cov‐2 PCR. There was involvement of both the oral and genital mucosa in all patients, with the exception of one case by Song et al, which was presumed to be recurrent RIME with only oral mucosal involvement.…”

A Severe Case of Post-COVID-19 Reactive Infectious Mucocutaneous Eruption in a Pediatric Patient

“…To the Editors: Mucosal manifestations of COVID-19 have been described with different presentations in both adults and children. 1,2 R eactive infectious mucocutaneous eruption (RIME) is a recently proposed term used to describe postinfectious mucositis cases, that is generally preceded by flulike symptoms. 3 It is considered a distinct entity from similar conditions such as Stevens-Johnson syndrome since it has predominant mucosal involvement rather than skin manifestations, and the course is often milder.…”