Reactive hyperemia is associated with adverse clinical outcomes in heart failure

Paine, Nicola J.; Hinderliter, Alan L.; Blumenthal, James A.; Chang, Patricia; O’Connor, Christopher M.

doi:10.1016/j.ahj.2016.05.008

Cited by 33 publications

(30 citation statements)

References 35 publications

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“…For example, modulation of myogenic tone by endothelial-dependent factors differed with sex in murine mesenteric arteries [49] and FMD in skeletal muscle arterioles was greater in females [50]. No sex differences were observed for FMD in a large population-based study [51], nor for FMD or reactive hyperemia in patients with heart failure [52]. Besides the above local regulatory mechanisms, circulating estrogen has cerebral vasodilatory activity, including promotion of eNOS/NO activity and dilatory prostanoids [41, 53] that affect these mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in the Cerebral Collateral Circulation

Faber

Moore

Lucitti³

et al. 2016

Transl. Stroke Res.

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Premenopausal women and intact female rodents sustain smaller cerebral infarctions than males. Several sex-dependent differences have been identified as potential contributors, but many questions remain unanswered. Mice exhibit wide variation in native collateral number and diameter (collateral extent) that is dependent on differences in genetic background, aging, and other comorbidities and that contributes to their also-wide differences in infarct volume. Likewise, variation in infarct volume correlates with differences in collateral-dependent blood flow in patients with acute ischemic stroke. We examined whether extent of pial collateral arterioles and posterior communicating collateral arteries (PComAs) differ depending on sex in young, aged, obese, hypertensive, and genetically different mice. We combined new data with meta-analysis of our previously published data. Females of C57BL/6J (B6) and BALB/cByJ (BC) strains sustained smaller infarctions than males after permanent MCA occlusion. This protection was unchanged in BC mice after introgression of the B6 allele of Dce1, the major genetic determinant of variation in pial collaterals among mouse strains. Consistent with this, collateral extent in these and other strains did not differ with sex. Extent of PComAs and primary cerebral arteries also did not vary with sex. No dimorphism was evident for loss of pial collateral number and/or diameter (collateral rarefaction) caused by aging, obesity, and hypertension, nor for collateral remodeling after pMCAO. However, rarefaction was greater in females with long-standing hypertension. We conclude that smaller infarct volume in female mice is not due to greater collateral extent, greater remodeling, or less rarefaction caused by aging, obesity, or hypertension.

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Section: Discussionmentioning

confidence: 99%

Sex Differences in the Cerebral Collateral Circulation

Faber

Moore

Lucitti³

et al. 2016

Transl. Stroke Res.

View full text Add to dashboard Cite

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“…20–22 On the other hand, Paine et al. 23 did not associate FMD with clinical outcomes in HF patients.…”

Section: Endothelial Dysfunction and Prognosismentioning

confidence: 93%

Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation

Giannitsi

Bougiakli

Bechlioulis

et al. 2019

JRSM Cardiovascular Disease

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Heart failure affects 1–2% of the population worldwide, and it is characterized by episodes of decompensation often requiring hospitalization. Although targeted treatment has reduced the prevalence of rehospitalizations to 30–50%, mortality rates remain high. A complex blend of structural and functional alterations accounts for the genesis and progression of heart failure, but the exact underlying pathophysiology remains poorly understood. The aim of this review is to summarize endothelial dysfunction and its role in the pathogenesis and progression of heart failure. Moreover, it sums up all the appropriate methods of assessing endothelial dysfunction emphasizing on flow-mediated dilation and introduces endothelium as a potential target for new therapeutic development and research in the wide spectrum of the syndrome called heart failure.

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“…To assess microvascular function, peak velocity during reactive hyperemia (VHR) and shear stress during reactive hyperemia (SSRH) were compared. SSRH was calculated according to the following formula: SSHR (dynes/cm 2 ) = 8 * 0.035 (dynes * s/cm 2 ) * (VRH/(baseline diameter/10)) (19,27,(37)(38)(39)).…”

Section: Measurement Of Brachial Artery Flow Mediated Dilation (Fmd)mentioning

confidence: 99%

Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people

Haptonstall

Choroomi

Moheimani

et al. 2020

American Journal of Physiology-Heart and Circulatory Physiology

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Tobacco cigarette(TC) smoking has never been lower in the US, but EC vaping has reached epidemic proportions amongst our youth. Endothelial dysfunction, as measured by flow mediated vasodilation(FMD) is a predictor of future atherosclerosis and adverse cardiovascular events, and is impaired in TC smokers, but whether FMD is also reduced in EC vapers is uncertain. The aim of this study in otherwise healthy young people was to compare the effects of acute and chronic TC smoking and EC vaping on FMD. FMD was compared in 47 non-smokers(NS), 49 chronic EC-vapers and 40 chronic TC-smokers at baseline, and then after EC-vapers(n=31) and non-smokers(n= 47) acutely used an EC-with-nicotine(ECN), EC-without-nicotine(EC0), and nicotine inhaler(NI) at ~4week intervals, and after TC-smokers(n=33) acutely smoked a TC, compared to sham-control. Baseline FMD was not different among the groups (NS:7.7±4.5%∆ vs EC:6.6±3.6%∆ vs TC:7.9±3.7%∆, p=0.35), even when compared by group and sex. Acute TC smoking vs control impaired FMD(FMD pre/post smoking: -2.52±0.92%∆ vs 0.65±0.93%∆, p=0.02). Although the increase in plasma nicotine was similar, acute EC vaping did not impair FMD. In otherwise healthy young people who regularly smoke TCs or ECs, impaired FMD was not present. However, FMD was significantly impaired after smoking one TC, but not after vaping an equivalent "dose"(estimated plasma nicotine) of an EC, consistent with the notion that non-nicotine constituents in TC smoke mediate the impairment. Although it is reassuring that acute EC-vaping did not acutely impair FMD, it would be dangerous and premature to conclude that ECs do not lead to atherosclerosis.

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Reactive hyperemia is associated with adverse clinical outcomes in heart failure

Cited by 33 publications

References 35 publications

Sex Differences in the Cerebral Collateral Circulation

Sex Differences in the Cerebral Collateral Circulation

Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation

Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people

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