Reactive Granular Cells in Sites of Trauma: A Cytochemical and Ultrastructural Study

Sobel, Harold J.; Avrin, Erna; Marquet, E; Schwarz, Ruth

doi:10.1093/ajcp/61.2.223

Cited by 53 publications

(19 citation statements)

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“…The history obtained in our two cases as well as in those reported by Van-Bernal and Mira [11]may support the hypothesis that traumatic factors play a role in the pathogenesis. This hypothesis is confirmed by the observation of reactive granular cell sites of surgical trauma [26]. This peculiar mesenchymal proliferation tends to support the concept that DFs are reactive rather than truly neoplastic processes.…”

Section: Discussionsupporting

confidence: 59%

Dermatofibroma with Granular Cells: A Report of Two Cases

Aloi

Albertazzi²,

Pippione³

1999

Dermatology

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We describe two examples of an unusual variant of dermatofibroma (DF) in which areas of granular cells were a prominent feature. The diagnosis of DF was confirmed by immunohistochemistry and by ultrastructural studies. Granular cell changes can be observed in numerous benign and malignant cutaneous tumors of different cellular lineage. Cellular granularity is a nonspecific phenomenon characterized by intracytoplasmic accumulation of lysosomes and may cause diagnostic difficulties. Traumatic factors may be involved in the pathogenesis of cellular granularity.

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Section: Discussionsupporting

confidence: 59%

Dermatofibroma with Granular Cells: A Report of Two Cases

Aloi

Albertazzi²,

Pippione³

1999

Dermatology

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“…In addition, the histiocytic cells were negative for S-100. Another reactive process, reactive granular cells secondary to trauma, described by Sobel et al, 28 may be harder to differentiate from GCT. The presence of multinucleated cells, iron or foreign material favors a diagnosis of reactive granular cells.…”

Section: Discussionmentioning

confidence: 99%

Features of Benign Granular Cell Tumor on Fine Needle Aspiration

et al. 1999

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“…These changes are much related with the accumulation of the lysosomes, which get increased during cellular degeneration7. Granular cell changes in the surgical trauma are mostly observed near smooth muscle at the sites of previous surgical trauma, especially in the uterine scar8. Granular cell traumatic neuroma could be differentiated from NN-GCT on the basis that the former consists of granular cells and hyperplastic nerve bundles with S-100 reactivity9.…”

Section: Discussionmentioning

confidence: 99%

Large Dermal Non Neural Granular Cell Tumor on the Surgical Wound Site

et al. 2011

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Granular cell tumors (GCTs) can be divided into neural type with S-100 reactivity and non-neural type without that. The latter has not been widely recognized and there are only fewer reports available when compared to conventional GCT. A 65-year-old man was presented with the presence of a painless mass on his back. The mass had developed into a small nodule on the scar developed because of previous surgery carried out 2 years ago. The tumor consisted of large, polygonal cells comprising of an enormous number of faintly eosinophilic small granules in the cytoplasm. The cytoplasmic granules were stained positively for periodic acid-Schiff stain. Immunohistochemical stains for S-100 protein and neuron-specific enolase were found to be negative. Herein, we report the appearance of a very rare case of non neural GCT developed on the surgical scar in support with relevant literature reviews.

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Reactive Granular Cells in Sites of Trauma: A Cytochemical and Ultrastructural Study

Cited by 53 publications

References 0 publications

Dermatofibroma with Granular Cells: A Report of Two Cases

Dermatofibroma with Granular Cells: A Report of Two Cases

Features of Benign Granular Cell Tumor on Fine Needle Aspiration

Large Dermal Non Neural Granular Cell Tumor on the Surgical Wound Site

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