Reactive extraction: a promising approach to separate protocatechuic acid

Antony, Fiona Mary; Wasewar, Kailas L.

doi:10.1007/s11356-019-06094-x

Cited by 34 publications

(18 citation statements)

References 97 publications

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“…Solvent extraction is a coupling fermentation technology in which LA is removed from fermenter using organic solvent extractant, then the organic phase loaded with LA is back extracted ( Figure 7). [41,54] Key parameters for extractant selection include selectivity, chemically stability, corrosivity, toxicity, and viscosity. [55] When the viscosity of the extractant is too high, it is necessary to add diluents.…”

Section: Reactive Extractionmentioning

confidence: 99%

Recent Advances on Purification of Lactic Acid

Meng

Zhang

Chuanqin

et al. 2020

The Chemical Record

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With increasing interest in developing biodegradable polymers to replace fossil-based products globally, lactic acid (LA) has been paid extensive attention due to the high environment-compatibility of its downstream products. The mainstream efforts have been put in developing energy-efficient conversion technologies through biological and chemical routes to synthesize LA. However, to our best knowledge, there is a lack of sufficient attention in developing effective separation technologies with high atom economics for purifying LA and derivatives. In this review, the most recent advances in purifying LA using precipitation, reactive extraction, emulsion liquid membrane, reactive distillation, molecular distillation, and membrane techniques will be discussed critically with respect to the fundamentals, flow scheme, energy efficiency, and equipment. The outcome of this article is to offer insights into implementing more atomic and energy-efficient technologies for upgrading LA.

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Section: Reactive Extractionmentioning

confidence: 99%

Recent Advances on Purification of Lactic Acid

Meng

Zhang

Chuanqin

et al. 2020

The Chemical Record

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“…For example, ultrafiltration [28], adsorption [29], are energy- and time-consuming options for PCA recovery from fermentation medium [30]. Recently, tri- n -butyl phosphate was used as a reactive extraction agent to form a complex with protonated PCA in the aqueous phase that can be extracted using an organic phase [31–34]. Moreover, an in situ product removal concept using reactive extraction was suggested to prevent product inhibition during the fermentation process [33].…”

Section: Introductionmentioning

confidence: 99%

Metabolic and Process Engineering for Microbial Production of Protocatechuate from Xylose withCorynebacterium glutamicum

Labib

Goertz

Bruesseler

et al. 2021

Preprint

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3,4-Dihydroxybenzoate (protocatechuate, PCA) is a phenolic compound naturally found in edible vegetables and medicinal herbs. PCA is of interest in the chemical industry as a building block for novel polymers and has wide potential for pharmaceutical applications due to its antioxidant, anti-inflammatory, and antiviral properties. In the present study, we designed and constructed a novel Corynebacterium glutamicum strain to enable the efficient utilization of D-xylose for microbial production of PCA. The engineered strain showed a maximum PCA titer of 62.1 ± 12.1 mM (9.6 ± 1.9 g L-1) from D-xylose as the primary carbon and energy source. The corresponding yield was 0.33 C-molPCA C-molXYL-1, which corresponds to 38 % of the maximum theoretical yield and is 14-fold higher compared to the parental producer strain on D-glucose. By establishing a one-pot bioreactor cultivation process followed by subsequent process optimization, the same maximum titer and a total amount of 16.5 ± 1.1 g was reached. Downstream processing of PCA from this fermentation broth was realized via electrochemically induced crystallization by taking advantage of the pH-dependent properties of PCA. Since PCA turned out to be electrochemically unstable in combination with several anode materials, a three-chamber electrolysis setup was established to crystallize PCA and to avoid direct anode contact. This resulted in a maximum final purity of 95.4 %. In summary, the established PCA production process represents a highly sustainable approach, which will serve as a blueprint for the bio-based production of other hydroxybenzoic acids from alternative sugar feedstocks.

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Section: Introductionmentioning

confidence: 99%

“…Reactive extraction method offers several advantages: it is a clean and economical method, energy efficient and can be used at industrial scale with existing equipment applied to different carboxylic acids 31–40 . In order to extend experimental knowledge and to improve theoretical approaches, extensive studies on reactive extraction for the separation of different carboxylic acids have been carried out recently 31–40 . The study on reactive extraction of 2‐ketogluconic acid by Georgiana et al 31 has focused on analyzing the pH‐dependent extraction performance and the molar ratios of acid and extractant Amberlite LA‐2 dissolved in three solvents with 1‐octanol as phase modifier.…”

Section: Introductionmentioning

confidence: 99%

Equilibrium study on the reactive extraction of heterocyclic monocarboxylic acids from the aqueous solution using Alamine 300/diluent composite solvent: Optimization and modeling of the solvent effect

Şenol

Yalçinkaya

2021

Asia-Pacific J Chem Eng

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Experiments were conducted to optimize the extraction equilibrium of reactive systems (water + heterocyclic carboxylic acid + Alamine 300/diluent) at T = 298.2 K and P = 101.3 kPa. The uptake capacity of the commercial composite solvent Alamine 300/diluent approximates the order: 2‐furoic acid ≥ alpha‐oxo‐2‐furanacetic acid > tetrahydro‐2‐furoic acid, and n‐heptane < 1,2‐dichloroethane < 1‐heptanol ≤ 2‐heptanone. Four differentiable models featuring the effects of separation ratio R and synergistic enhancement SE factors are stringently tested to identify global optimization ranges by derivative variation method as follows: 0.2 < R < 0.8 and 4 < SE < 7 for 1‐heptanol and 2‐heptanone, 1.2 < R < 3.5 and 4 < SE < 6.5 for 1,2‐dichloroethane, 2 < R < 80 and 4 < SE < 80 for n‐heptane, and Alamine 300 concentration 0.12–0.18 mol dm−3. Consecutively, the optimum mass transfer stages of a countercurrent extraction are calculated by Kremser–Souders–Brown equation. The equilibrium properties are estimated precisely according to linear solvation energy relation with substantial improvement linear solvation energy relation with substantial improvement (LSER‐si), solvation probability relation solvation probability relation (SPR) and Chemodel‐modified yielding mean relative errors of 7.0%, 0.08% and 20.4%, respectively.

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Reactive extraction: a promising approach to separate protocatechuic acid

Cited by 34 publications

References 97 publications

Recent Advances on Purification of Lactic Acid

Recent Advances on Purification of Lactic Acid

Metabolic and Process Engineering for Microbial Production of Protocatechuate from Xylose withCorynebacterium glutamicum

Equilibrium study on the reactive extraction of heterocyclic monocarboxylic acids from the aqueous solution using Alamine 300/diluent composite solvent: Optimization and modeling of the solvent effect

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