Reactive Epstein-BarrVirus--Related Polyclonal Lymphoproliferative Disorder in a Patient with AIDS

Martin, Stanley I.; Zukerberg, Lawrence; Robbins, Gregory K.

doi:10.1086/444564

Cited by 17 publications

(15 citation statements)

References 18 publications

(20 reference statements)

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“…Most lesions are EBV þ . 89,[161][162][163][164] Many cases are monoclonal, based on genetic studies, but structural alterations in oncogenes and tumor suppressor genes are generally rare. 163 Although clinical outcome information is limited, at least one patient experienced regression of their polymorphic lymphoid lesion following antiviral therapy.…”

Section: Lymphomas Occurring In Other Immunodeficient Statesmentioning

confidence: 99%

“…163 Although clinical outcome information is limited, at least one patient experienced regression of their polymorphic lymphoid lesion following antiviral therapy. 164 may arise. Although most lymphomas that arise in patients infected with HIV are diffuse aggressive B-cell lesions, other lesions, which are ''benign'' lymphoid proliferations, may be associated with significant clinical consequences.…”

Section: Lymphomas Occurring In Other Immunodeficient Statesmentioning

confidence: 99%

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Lymphoid Proliferations Associated With Human Immunodeficiency Virus Infection

Chadburn

Abdul-Nabi

Teruya

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Individuals who are immune deficient are at an increased risk for developing lymphoproliferative lesions and lymphomas. Human immunodeficiency virus (HIV) infection is 1 of 4 clinical settings associated with immunodeficiency recognized by the World Health Organization (WHO) in which there is an increased incidence of lymphoma and other lymphoproliferative disorders. Objectives.—To describe the major categories of benign lymphoid proliferations, including progressive HIV-related lymphadenopathy, benign lymphoepithelial cystic lesions, and multicentric Castleman disease, as well as the different types of HIV-related lymphomas as defined by the WHO. The characteristic morphologic, immunophenotypic, and genetic features of the different entities will be discussed in addition to some of the pathogenetic mechanisms. Data Sources.—The WHO classification of tumors of hematopoietic and lymphoid tissues (2001 and 2008), published literature from PubMed (National Library of Medicine), published textbooks, and primary material from the authors' current and previous institutions. Conclusions.—HIV infection represents one of the clinical settings recognized by the WHO in which immunodeficiency-related lymphoproliferative disorders may arise. Although most lymphomas that arise in patients with HIV infection are diffuse, aggressive B-cell lesions, other lesions, which are “benign” lymphoid proliferations, may also be associated with significant clinical consequences. These lymphoproliferations, like many other immunodeficiency-associated lymphoproliferative disorders, are often difficult to classify. Studies of HIV-associated lymphoid proliferations will continue to increase our understanding of both the immune system and lymphomagenesis.

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Section: Lymphomas Occurring In Other Immunodeficient Statesmentioning

confidence: 99%

Section: Lymphomas Occurring In Other Immunodeficient Statesmentioning

confidence: 99%

Lymphoid Proliferations Associated With Human Immunodeficiency Virus Infection

Chadburn

Abdul-Nabi

Teruya

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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“…Burkitt lymphoma, diffuse large B-cell lymphoma and Hodgkin lymphoma [1,3]. This case represents an EBV-associated polymorphic lymphoid proliferation resembling those more often encountered in transplant recipients [1,[4][5][6][7][8]. Such lymphoproliferations include early infectious mononucleosis (IM)-like PTLDs and polymorphic PTLDs, entities that show overlapping pathological features and represent closely related points on a continuous spectrum of disease.…”

Section: Discussionmentioning

confidence: 99%

“…However, we accept that the architectural effacement was relatively minor and that small clones can rarely be encountered in early IM-like PTLDs [2]. Although polymorphic PTLDs constitute a relatively high proportion of the lymphoid proliferations in transplant patients, they have only rarely been reported in association with HIV infection and there is relatively little information on the response to treatment and prognosis [1,2,[4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Including the current patient, a total of 17 cases of HIVassociated polymorphic lymphoproliferations have been reported, including both adult and paediatric examples, with an excess of male patients (11 male to 6 female) [1,[4][5][6][7][8]. The majority of cases (11 out of 17) have presented at extranodal sites, including the lung (n05), parotid gland (n01), perineum (n01), skin (n01), stomach (n01), terminal ileum (n01) and CNS (n01) [1,[4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

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Polymorphic lymphoid proliferations occurring in HIV-positive patients: report of a case responding to HAART

2012

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Epstein-Barr virus (EBV)-associated polymorphic lymphoid proliferations resembling polymorphic post-transplant lymphoproliferative disorders are a rare but recognised complication of the human immunodeficiency virus (HIV). These account for fewer than 5 % of HIV-associated lymphomas, and little information has been published regarding their treatment and outcome. Of the reported cases, many have presented with extranodal disease, not typical of lymphoma. We report the case of a patient presenting with lung infiltrates shown to be the result of an EBV-associated polymorphic lymphoproliferation resembling a polymorphic post-transplant lymphoproliferative disorder. The patient was simultaneously found to be HIV positive and commenced on highly active antiretroviral therapy. Without any specific anti-neoplastic treatment, the patient recovered completely and within 20 months had no symptoms or radiological evidence of a lymphoproliferative disorder. This illustrates the importance of recognising this uncommon condition in HIV-positive patients and avoiding potentially unnecessary chemotherapy.

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Managing Infections in Patients With Hematological Malignancies

Kleinberg¹

2010

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Reactive Epstein-BarrVirus--Related Polyclonal Lymphoproliferative Disorder in a Patient with AIDS

Cited by 17 publications

References 18 publications

Lymphoid Proliferations Associated With Human Immunodeficiency Virus Infection

Lymphoid Proliferations Associated With Human Immunodeficiency Virus Infection

Polymorphic lymphoid proliferations occurring in HIV-positive patients: report of a case responding to HAART

Managing Infections in Patients With Hematological Malignancies

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