Reactive eccrine syringofibroadenoma in hyperkeratotic eczema

Desai, Chirag; Khopkar, Uday

doi:10.4103/2229-5178.185476

Cited by 3 publications

(4 citation statements)

References 3 publications

(7 reference statements)

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“…A diagnosis of SSPS was not considered until ESFA changes were found in additional biopsies. Although palmoplantar keratoderma with ESFA was thought initially to be specific for SSPS, 3 there are a few reports of ESFA changes in patients with Clouston Syndrome (hypohidrotic ED), as well as a reactive phenomenon in inflammatory dermatoses, especially those with an ulcerative component 5‐8 . It could be possible that the hyperplastic proliferation of eccrine ducts seen in this case was induced by chronic palmo‐plantar keratoderma.…”

Section: Discussionmentioning

confidence: 86%

Eccrine syringofibroadenoma as a clue for the diagnosis of Schöpf‐Schulz‐Passarge syndrome in acquired palmoplantar keratoderma

et al. 2020

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Section: Discussionmentioning

confidence: 86%

Eccrine syringofibroadenoma as a clue for the diagnosis of Schöpf‐Schulz‐Passarge syndrome in acquired palmoplantar keratoderma

et al. 2020

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“…1 Histologically, ESFA should be differentiated from fibroepithelioma of Pinkus, hidroacanthoma simplex, tumor of the follicular infundibulum, poroma, reticulated seborrheic keratosis, and squamous cell carcinoma with ductal differentiation. 3,12,13 The association of reactive ESFA with a malignant skin condition is extremely rare. It is difficult to distinguish whether ESFA precedes the treatment of carcinomas, or it is a reactive change secondary to carcinomas excision.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Reactive Eccrine Syringofibroadenoma (ESFA) in Association With a Merkel Cell Carcinoma Excision Scar

Salah

Czelusta

Sánchez³

2022

The American Journal of Dermatopathology

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:Eccrine syringofibroadenoma (ESFA) is a rare benign skin adnexal lesion of the acrosyringium of eccrine sweat ducts. Reactive ESFA, a subtype of ESFA, is usually associated with non-neoplastic cutaneous dermatoses or neoplastic skin tumors. Clinically, the lesions can be solitary or multiple, pink, or skin-colored coalescing papules or nodules of variable sizes. Histopathologically, this tumor is composed of numerous anastomosing cords of monomorphic cuboidal epithelial cells with eccrine duct formation. The association of reactive ESFA with benign conditions, such as psoriasis, diabetic polyneuropathy, scars, and leprosy, has been reported. However, the association of reactive ESFA with malignant tumors is extremely rare, with very few cases reported in the literature. We present a case of a 72-year-old woman who developed reactive ESFA associated with Merkel cell carcinoma excision scar. The ESFA tumors developed in the area of the surgical graft 10 months after the Merkel cell carcinoma had been excised. New ESFA tumors have continued to appear in the scar on a yearly basis while, so far, has been no recurrence of the original tumor. However, the presence of new tumor growths in the area suggested the possibility of recurrence of the Merkel cell carcinoma. That possibility was enhanced by the fact that PET scans revealed hypermetabolic activity in the ESFA papules.

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“…The reactive subtype ESFA is associated with skin neoplasia such as squamous cell carcinoma, 6 basal cell carcinoma, 7 and pilomatricoma. 8 Reactive ESFA has also been reported to be associated with inflammatory skin disorders such as palmoplantar eczema, 9 bullous pemphigoid, 10 erosive lichen planus, 11 primary cutaneous amyloidosis, 12 peristomal dermopathy, 13 and chronic ulceration.…”

Section: Discussionmentioning

confidence: 99%

Reactive Eccrine Syringofibroadenomatosis Associated With Venous Leg Ulcers: A Case Report and Literature Review

Tedbirt

Carvalho

Boulard³

et al. 2020

The International Journal of Lower Extremity Wounds

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Eccrine syringofibroadenoma (ESFA) is a rare adnexal tumor deriving from the acrosyringeal portion of the eccrine duct. Five subtypes of ESFA were described including a reactive form. Reactive ESFAs are associated with inflammatory and neoplastic dermatoses. In this article, we report the case of a 90-year-old woman presenting with 3 leg ulcers evolving for 2 years surrounded by large verrucous and eczematous lesions. Multiple skin biopsies showed anastomosing epithelial cords connected to the epidermis consistent with ESFA. We identified 8 cases of ESFA associated with chronic leg ulcers in the literature and reviewed their main clinical and histological features.

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Reactive eccrine syringofibroadenoma in hyperkeratotic eczema

Cited by 3 publications

References 3 publications

Eccrine syringofibroadenoma as a clue for the diagnosis of Schöpf‐Schulz‐Passarge syndrome in acquired palmoplantar keratoderma

Eccrine syringofibroadenoma as a clue for the diagnosis of Schöpf‐Schulz‐Passarge syndrome in acquired palmoplantar keratoderma

Reactive Eccrine Syringofibroadenoma (ESFA) in Association With a Merkel Cell Carcinoma Excision Scar

Reactive Eccrine Syringofibroadenomatosis Associated With Venous Leg Ulcers: A Case Report and Literature Review

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