Reactive distillation for methyl acetate production

Huss, Robert S.; Chen, Fengrong; Malone, Michael F.; Doherty, Michael F.

doi:10.1016/s0098-1354(03)00156-x

Cited by 71 publications

(40 citation statements)

References 22 publications

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“…To investigate the feasibility of the RD alternatives, the RD flowsheet alternatives are rigorously simulated. It is found that for RD columns with single feed, the MeOH/MeOAc azeotrope is obtained at the top of the column whereas at the bottom of the column a mixture of H 2 O and HOAc is obtained [14], which can also be seen from the RCM in Fig. 12b, where the starting point of the residue curves are from the MeOH/MeOAc azeotrope.…”

Section: Detailed Analysis Of Flowsheet Alternatives 6-9mentioning

confidence: 63%

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A process synthesis-intensification framework for the development of sustainable membrane-based operations

Babi

Lutze

Woodley

et al. 2014

Chemical Engineering and Processing: Process Intensification

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Section: Detailed Analysis Of Flowsheet Alternatives 6-9mentioning

confidence: 63%

“…The specified target for production is 17,009 kg/h (122 × 10 3 tons/year) [14]. The purity of the product should be greater than or equal to 99 mol%.…”

Section: 1mentioning

confidence: 99%

A process synthesis-intensification framework for the development of sustainable membrane-based operations

Babi

Lutze

Woodley

et al. 2014

Chemical Engineering and Processing: Process Intensification

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“…33,34 Well-known examples include the production of methyl acetate from methanol and acetic acid [35][36][37] and production of methyl t-butyl ether from methanol and isobutene. 38 Reactions of this type often are carried out in the presence of an acid catalyst such as homogeneous sulfuric acid or heterogeneous sulfonated ion-exchange beads installed in packets at specific tray or packing locations within the column.…”

Section: Standard Column Designsmentioning

confidence: 99%

Horizontal reactive distillation for multicomponent chiral resolution

et al. 2013

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A novel horizontal reactive distillation apparatus and a new overall process scheme are proposed for continuous multicomponent chiral resolution via reversible enantioselective acylation of a chiral (racemic) substrate by a chiral (racemic) acyl donor. The process enables simultaneous production of up to four enantiomers with enhanced chiral purity. Kinetic studies, miniplant experiments, and process simulation results are described for a model lipase-catalyzed reaction: (R)-enantioselective transesterification of (R,S)-1-n-butoxy-2-propanol with (R,S)-1-methoxy-2-acetoxypropane to produce (R)-1-nbutoxy-2-acetoxypropane, (R)-1-methoxy-2-propanol, and the two unreacted (S)-enantiomers of the (R,S)-reagents. A horizontal, compartmentalized reactive distillation vessel is specified instead of a conventional reactive distillation column to provide longer liquid-phase residence time needed for adequate conversion. Low vapor-traffic pressure drop allows operation under vacuum at reduced temperatures for good enzyme stability and enantioselectivity. The general technology has potential as a means to producing a wide range of chiral synthons used in asymmetric syntheses of chiral pharmaceuticals and other biologically active products.

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“…There are many documented success stories involving the industrial implementation of reactive distillation [1,2,3,4]. The applications of reactive distillation in the chemical and petroleum industries have increased rapidly in the past decade.…”

Section: Introductionmentioning

confidence: 99%

“…The applications of reactive distillation in the chemical and petroleum industries have increased rapidly in the past decade. One example is the manufacture of methyl acetate by the Eastman Chemical Company [1].In their case, a single reactive distillation column has replaced the traditional flow sheet consisting of eleven major unit operations along with other equipment such as heat exchangers, pumps and controllers. The result had been a fivefold reduction in capital investment and energy consumption when compared to methyl acetate production using conventional designs [1].…”

Section: Introductionmentioning

confidence: 99%

Modelling of Reactive Distillation for Acetic Acid Esterification

Kandanapitiya

Gunasekera

2015

Engineer

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Abstract:Esterification reactions are limited by chemical equilibrium and therefore they are carried out commercially using either a large excess of one of the reactants or by removing one of the products continuously. The removal of one of the products continuously can be achieved by carrying out reactive distillation where reaction and separation are performed simultaneously. This work presents an approach for mathematical modelling and simulation of batch reactive distillation which can be used by design engineers to obtain key information such as composition and temperature variation as the reaction progresses with time, product composition and the quantity accumulated in the distillate and the most suitable reflux conditions needed for high product separation rates. The process unit studied consists of a batch reactor with single stage distillation and a condenser. The mathematical model considered material balance equations, equilibrium relationships, summation equations and energy balance equations. The model was simulated for acetic acid and ethanol esterification reaction. The reactor composition variation in modelling and simulation results show a decrease in acetic acid and ethanol reactant compositions with time while ethyl acetate and water compositions show an increase. The ethyl acetate mole fraction in the condenser increases as the reflux ratio increases.

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Reactive distillation for methyl acetate production

Cited by 71 publications

References 22 publications

A process synthesis-intensification framework for the development of sustainable membrane-based operations

A process synthesis-intensification framework for the development of sustainable membrane-based operations

Horizontal reactive distillation for multicomponent chiral resolution

Modelling of Reactive Distillation for Acetic Acid Esterification

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