Reactivation of SARS‐CoV‐2 after recovery

Yoo, Si Yoon; Lee, Youngseok; Lee, Ga Hee; Kim, Dong Hyun

doi:10.1111/ped.14312

Cited by 26 publications

(23 citation statements)

References 4 publications

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“…The three cases we present here did not received diagnostic tests, supposedly negative, during the transient improvement in clinical signs 14 . Prolonged infections 15‐17 and reactivations have already been described previously 18‐20 . If the risk of recurrence is confirmed, it will be crucial to analyze the risk factors (comorbidities, undernutrition, lymphopenia, and weak immune reaction with a low or even negative serology) but also their severity.…”

Section: Discussionmentioning

confidence: 96%

Recurrence or Relapse of COVID‐19 in Older Patients: A Description of Three Cases

Lafaie

Célarier

Goethals

et al. 2020

J American Geriatrics Society

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BACKGROUND: COVID-19 has infected millions of people worldwide, particularly in older adults. The first cases of possible reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were reported in April 2020 among older adults. DESIGN/SETTING: In this brief report, we present three geriatric cases with two episodes of SARS-CoV-2 infection separated by a symptom-free interval. PARTICIPANTS: The participants of this brief report are three cases of hospitalized geriatric women. MEASUREMENTS/RESULTS: We note clinical and biological worsening during the second episode of COVID-19 for all three patients. Also, there is a radiological aggravation. The second episode of COVID-19 was fatal in all three cases. CONCLUSION: This series of three geriatric cases with COVID-19 diagnosed two times apart for several weeks questions the possibility of reinfection with SARS-CoV-2. It raises questions in clinical practice about the value of testing for SARS-CoV-2 infection again in the event of symptomatic reoccurrence.

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Section: Discussionmentioning

confidence: 96%

Recurrence or Relapse of COVID‐19 in Older Patients: A Description of Three Cases

Lafaie

Célarier

Goethals

et al. 2020

J American Geriatrics Society

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“…Nine patients' information has been previously reported. 6,12,13 The median age was 11 years (range, 27 days-18 years). Fifty-three patients (58%) were male, and 6 (7%) had underlying diseases ( Table 1).…”

Section: Epidemiology Of Covid-19 In Childrenmentioning

confidence: 99%

Clinical Characteristics and Viral RNA Detection in Children With Coronavirus Disease 2019 in the Republic of Korea

et al. 2021

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IMPORTANCE There is limited information describing the full spectrum of coronavirus disease 2019 (COVID-19) and the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA detection in children. OBJECTIVE To analyze the full clinical course and the duration of SARS-CoV-2 RNA detectability in children confirmed with COVID-19 in the Republic of Korea, where rigorous public health interventions have been implemented. DESIGN, SETTING, AND PARTICIPANTS This case series of children with COVID-19 was conducted in 20 hospitals and 2 nonhospital isolation facilities across the country from February 18, 2020, to March 31, 2020. Children younger than 19 years who had COVID-19 were included. EXPOSURES Confirmed COVID-19, detected via SARS-CoV-2 RNA in a combined nasopharyngeal and oropharyngeal swab or sputum by real-time reverse transcriptionpolymerase chain reaction. MAIN OUTCOMES AND MEASURES Clinical manifestations during the observation period, including the time and duration of symptom occurrence. The duration of SARS-CoV-2 RNA detection was also analyzed. RESULTS A total of 91 children with COVID-19 were included (median [range] age, 11 [0-18] years; 53 boys [58%]). Twenty children (22%) were asymptomatic during the entire observation period. Among 71 symptomatic cases, 47 children (66%) had unrecognized symptoms before diagnosis, 18 (25%) developed symptoms after diagnosis, and only 6 (9%) were diagnosed at the time of symptom onset. Twenty-two children (24%) had lower respiratory tract infections. The mean (SD) duration of the presence of SARS-CoV-2 RNA in upper respiratory samples was 17.6 (6.7) days. Virus RNA was detected for a mean (SD) of 14.1 (7.7) days in asymptomatic individuals. There was no difference in the duration of virus RNA detection between children with upper respiratory tract infections and lower respiratory tract infections (mean [SD], 18.7 [5.8] days vs 19.9 [5.6] days; P = .54). Fourteen children (15%) were treated with lopinavir-ritonavir and/or hydroxychloroquine. All recovered, without any fatal cases. CONCLUSIONS AND RELEVANCE In this case series study, inapparent infections in children may have been associated with silent COVID-19 transmission in the community. Heightened surveillance using laboratory screening will allow detection in children with unrecognized SARS-CoV-2 infection.

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“…On the other hand, recommending higher intensity exercise needs further consideration to make final decision in this regard. Reactivation of the infection has been previously reported both in adults [3] and in children [4]. We report a case of a patient with reactivation of SARS-CoV-2 infection after strenuous exercise in the gym.…”

mentioning

confidence: 76%

Clinical Case: SARS-CoV-2 Reactivation After a Heavy Workout

Hadzhimineva

Simidchiev

2020

Acta Medica Bulgarica

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We present a clinical case of a patient with reactivation of SARS-CoV-2 infection after strenuous exercise in the gym. Reactivation of the virus was confirmed after detecting SARS-CoV-2 in a nasopharyngeal swab sample using real-time polymerase chain reaction (PCR). The clinical symptoms of the patient – fever and shortness of breath, as well as the presence of IgM antibodies further confirmed the diagnosis. The subjective complaints of persistent shortness of breath for more than a few weeks were noted.

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Reactivation of SARS‐CoV‐2 after recovery

Cited by 26 publications

References 4 publications

Recurrence or Relapse of COVID‐19 in Older Patients: A Description of Three Cases

Recurrence or Relapse of COVID‐19 in Older Patients: A Description of Three Cases

Clinical Characteristics and Viral RNA Detection in Children With Coronavirus Disease 2019 in the Republic of Korea

Clinical Case: SARS-CoV-2 Reactivation After a Heavy Workout

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