Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy

Fusco, Dahlene N.; Ganova-Raeva, Lilia; Khudyakov, Yury; Punkova, Lili; Mohamed, Aisha; Cheon, Scarlett Se Yun; Koirala, Prapti; Andersson, Karin L.; Jourdain, Gonzague; Sureau, Camille; Chung, Raymond T.; Lauer, Georg M.

doi:10.3389/fmed.2018.00097

Cited by 2 publications

(3 citation statements)

References 47 publications

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“…It can only emerge to become the major viral population in patients in the face of immune pressure, usually vaccine-induced or prophylactic treatment of liver transplant patients with human anti-HBs immunoglobulins (HBIg). Accordingly, in the majority of reported cases of reactivation, this mutation was found in patients positive for anti-HBs antibodies at baseline and sometimes even after the onset of reactivation [66,68,69,73,81,83,84,85].…”

Section: Mutations Associated With Hbv Reactivationmentioning

confidence: 99%

“…So far, the presence of BCP and Pre-C mutations has not been often investigated in patients with HBV reactivation. The double BCP mutation (A1762T/G1764A), as well as their separate presence and presence of an additional BCP mutation C1766G, were reported in some cases of reactivation [68,84,86,90]. Pre-C mutations G1896A and A1899G were detected [68,69,90] separately or in combination with mutations in the BCP and were correlated with a rapid increase of HBV DNA prior to HBV reactivation [90] and fatal outcomes [68].…”

Section: Mutations Associated With Hbv Reactivationmentioning

confidence: 99%

“…HBsAg mutations within major hydrophilic region (MHR) reported in patients suffering from HBV reactivation; in orange—MHR, aa 99–169; in pink—“ a ” determinant within MHR, aa124–147; Ref—reference [66,67,68,69,70,71,72,73,74,80,81,82,83,84,85,86,87,88,89,90]. …”

Section: Figurementioning

confidence: 99%

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Immune-Escape Hepatitis B Virus Mutations Associated with Viral Reactivation upon Immunosuppression

Lazarević

Banko

Miljanovic

et al. 2019

Viruses

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Hepatitis B virus (HBV) reactivation occurs as a major complication of immunosuppressive therapy among persons who have recovered from acute hepatitis and those who have controlled chronic infection. Recent literature data emphasize the presence of a high degree of S gene variability in HBV isolates from patients who developed reactivation. In reactivated HBV, the most frequently detected mutations belong to the second loop of “a” determinant in HBsAg. These mutations were identified to be immune escape and responsible for vaccine- and diagnostic-escape phenomena. Their emergence clearly provides survival in the presence of a developed humoral immune response and is often associated with impaired serological diagnosis of HBV reactivation. The knowledge of their existence and roles can elucidate the process of reactivation and strongly highlights the importance of HBV DNA detection in monitoring all patients with a history of HBV infection who are undergoing immunosuppression. This review discusses the possible influence of the most frequently found immune-escape mutations on HBV reactivation.

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Section: Mutations Associated With Hbv Reactivationmentioning

confidence: 99%

Section: Mutations Associated With Hbv Reactivationmentioning

confidence: 99%

See 1 more Smart Citation

Immune-Escape Hepatitis B Virus Mutations Associated with Viral Reactivation upon Immunosuppression

Lazarević

Banko

Miljanovic

et al. 2019

Viruses

View full text Add to dashboard Cite

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Hepatitis B virus reactivation sustained by a hepatitis B virus surface antigen immune-escape mutant isolate in a patient who was hepatitis B core antibody positive during treatment with sofosbuvir and velpatasvir for hepatitis C virus infection: a case report

et al. 2019

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Background Although several cases of hepatitis B virus reactivation have been described in patients with a history of hepatitis B virus infection while undergoing treatment for hepatitis C virus infection with direct acting antivirals, the question of whether hepatitis B virus surface antigen immune-escape mutations might play a role has not been addressed so far. Case presentation We report a case of hepatitis B virus reactivation in a Caucasian patient infected with hepatitis C virus during treatment with sofosbuvir and velpatasvir. A 50-year-old man with a genotype 1a hepatitis C virus infection was considered for therapy. His serological profile was hepatitis B virus surface antigen-negative, hepatitis B virus core antibody-positive, hepatitis B virus surface antibody-negative, and anti-hepatitis D virus-positive. The detection of hepatitis B virus deoxyribonucleic acid (DNA) indicated active viral replication during the direct acting antiviral treatment that spontaneously returned to undetectable levels after treatment completion. Starting from week 12 after the end of treatment, hepatitis B virus surface antibody titers and hepatitis B virus e antibody developed. Sequencing analysis revealed the hepatitis B virus genotype D3 and the presence of two relevant immune-escape mutations (P120S and T126I) in the major hydrophilic region by analyzing the S region. Conclusions We speculate that the presence of the hepatitis B virus surface antigen mutations, endowed with the enhanced capability to elude the immune response, could play a role in hepatitis B virus reactivation. This observation confirms that occult hepatitis B infection should also be carefully monitored, through surveillance of the hepatitis B virus viral load before and during direct acting antiviral treatment of hepatitis C virus.

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Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy

Cited by 2 publications

References 47 publications

Immune-Escape Hepatitis B Virus Mutations Associated with Viral Reactivation upon Immunosuppression

Immune-Escape Hepatitis B Virus Mutations Associated with Viral Reactivation upon Immunosuppression

Hepatitis B virus reactivation sustained by a hepatitis B virus surface antigen immune-escape mutant isolate in a patient who was hepatitis B core antibody positive during treatment with sofosbuvir and velpatasvir for hepatitis C virus infection: a case report

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