Reactions with Thiazolo[3,2‐b]‐s‐triazol‐3(2H)‐ones

Abstract

5‐Aryl‐3‐carboxymethylthio‐1,2,4‐triazoles 2 are cyclised to 6‐arylthiazolo[3,2‐b]‐s‐triazol‐3(2H)‐ones 3. This structural assignment has been based on IR and NMR spectra. 2‐Arylmethylene‐6‐arylthiazolo[3,2‐b]‐s‐triazol‐3(2H)‐ones 7 were prepared by several methods. Compounds 3 coupled with diazotised anilines to give 2,3‐dihydro‐6‐arylthiazolo[3,2‐b]‐s‐triazole‐2,3‐dione 2‐arylhydrazones 8. The action of amines on 3a opens the thiazolone ring with the formation of substituted (5‐phenyltriazol‐3‐ylthio)‐acetamides 9.

Synthesis and Evaluation of Anti-Inflammatory Activity of Some Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and Their Michael Addition Products

“…The structures of the isolated compounds were determined by IR, 1 H-NMR spectral data, X-ray crystallographic and elementary analysis. The compounds 4−6 and 8 have already been synthesized by Ali et al[19] and anti-inflammatory activities of these compounds have not been reported. Conjugate additions of cyclic sec.…”

Thermo‐physical properties of n‐pentane/bitumen and n‐hexane/bitumen mixture systems

“…Hybrid methods in which steam and solvent are co-injected have been suggested to overcome some of the limitations of each method. Several studies, including Ali and Abad, [1] Redford and McKay, [2] Redford, [3] Shu and Hartman, [4] Sarma et al, [5] Nasr et al, [6] Nasr and Ayodele, [7] Ayodele et al, [8] McCormack, [9] and Mohammadzadeh et al [10] have investigated the co-injection of solvent and steam for the recovery of heavy oil and bitumen.…”

Reactions with 5,6,7-Trihydro-5,7-diarylthiazolo [3,2-b] -s-triazin-3(2 H)-ones

“…This carbonyl frequency is rather high; however, it has been noted that a carbonyl group attached to a triazole and a triazine rings shows unusually high stretching frequency [5][6][7][8] . The NMR spectrum (DMSO-d6) of 3 a, shows a methylene group (s, 2H) at r 5.27 ppm.…”