REACTIONS WITH CYANOTHIOACETAMIDE DERIVATIVES: SYNTHESIS AND REACTIONS OF SOME PYRIDINES AND THIENO[2,3-<i>b</i>]PYRIDINE DERIVATIVES

Attaby, Fawzy A.; Eldin, Sanaa M.; Razik, M.

doi:10.1080/10426509508027885

Cited by 36 publications

(13 citation statements)

References 4 publications

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“…Cytotoxic and biological effects of tested compounds against liver cancer cell line Compounds 3,4,5,6,7,8,10,11,12,13,17, and 18 were soluble in DMSO at concentrations high enough to allow cell experiments; the in vitro biological activity of these compounds was evaluated by their growth-inhibitory potency in liver HEPG2 cancer cell lines. The cytotoxic potency of compounds 3,4,5,6,7,8,10,11,12,13,17, and 18 were studied in comparison to the known anticancer drugs 5-flurouracil (5-FU) and doxorubicin (DOX).…”

Section: Antitumor Activitymentioning

confidence: 99%

“…N-acyl pyridine derivatives have also attracted considerable attention due to their hydrogen bonding motifs [1][2][3]. Poly functional pyridines are highly reactive reagents that have been used extensively in heterocyclic synthesis [4][5][6][7] and that possess biological as well as pharmacological activity [8][9][10]. In addition, triazolopyridines are also interesting compounds due to their pronounced biological activity, as they can be used as antidepressants [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and anticancer activity of some new pyridine derivatives

et al. 2011

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Different substituents were introduced in positions 2 and 6 of 2,6 diaminopyridine in order to obtain new heterocyclic compounds. A new series of aza pyridine, imidazopyridine, benzodiazepine, indole, pyrimidine, and benzimidazole heterocyclic derivatives were synthesized in good yields. The anticancer activities of some of the new compounds were evaluated against liver cancer cell line HEPG2. Compounds 3, 4, 10, 11, 12, and 17 showed the highest activity when compared to 5-flurouracil (5-FU) and doxorubicin (DOX) chemotherapy.

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Section: Antitumor Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and anticancer activity of some new pyridine derivatives

et al. 2011

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“…Polyfunctional pyridines are extensively used in heterocyclic synthesis because of their high reactivity as synthons. [1][2][3] 2-Pyridones are an important subcategory of pyridines that have various biological activities. 2-Pyridone derivatives have appeared as vital backbones in over 7000 surviving drugs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a novel heterocyclic scaffold utilizing 2-cyano-N-(3-cyano-4,6-dimethyl-2-oxopyridin-1-yl) acetamide

Khidre¹,

Radini²,

Ibrahima³

2016

Arkivoc

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2-Cyano-N-(3-cyano-4,6-dimethyl-2-oxopyridin-1-yl)acetamide (3) was prepared via two routes and its reactions with various aldehydes and diazonium salts were studied. When compound 3 was treated with arylidenemalononitrile in either ethanol or dioxane using piperidine as a catalyst in a trial to prepare bispyridone derivatives 7, there was no reaction and the reason for this was investigated using molecular modeling. Furthermore, coumarin derivatives 9 and 10 were prepared by reaction of acetamide 3 with salicylaldehyde derivatives. Finally, aminopyrazole derivatives 15 were synthesized by reaction of acetamide 3 with N,N-dimethylformamide dimethyl acetal (DMFDMA) then with hydrazine derivatives and their mechanisms was discussed.

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“…Heterocyclic chemistry is recently experiencing broad area of interest because of their potent biological activity [1][2][3] . Incorporation of hetero atoms within the carbon framework often leads to new type of molecules, which are primarily biological important.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antioxidant Activity of 6-Imino-4-(Methylthio)-2-(Pyridine-3-Yl)-6h-1,3-Thiazine-5-Carbonitrile

Kawale¹,

Vartale²,

Kalyankar³

2017

Int. Res. J. Pharm.

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Synthesis of novel heterocyclic 6-imino-4-(methylthio)-2-(pyridin-3-yl)-6H-1,3-thiazine-5-carbonitrile (3) was prepared by condensing thionicotinamide (1) with bis(methylthio)methylene malononitrile (2) in DMF and potassium carbonate as catalyst. Compound (3) has methylthio group at fourth position, which is replaced by different nucleophiles such as substituted anilines, phenols, hetryl amines and compounds containing active methylene group to afford 4-substituted derivatives of compound (3). The newly synthesized compounds were characterized by IR, 1 H-NMR, Mass spectral analysis. Furthermore, these synthesized compounds were tested for antioxidant activity. The result of antioxidant activity reveals that most of the compounds shows potent activity. The major advantage of this protocol is operational simplicity and high yield.

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REACTIONS WITH CYANOTHIOACETAMIDE DERIVATIVES: SYNTHESIS AND REACTIONS OF SOME PYRIDINES AND THIENO[2,3-b]PYRIDINE DERIVATIVES

Abstract: The styrlpyridinethione la-c reacted with several halogenated compounds; w-bromoacetophenone, methyl chloroacetate, a-chloroacetylacetone and ethyl-a-chloroacetoacetate to give the corresponding thieno[2,3-b]pyridines 3a-c, 1 la-c and the thiazolo[3.2-a]pyridines 1 4 -c .

Cited by 36 publications

References 4 publications

Synthesis and anticancer activity of some new pyridine derivatives

Synthesis and anticancer activity of some new pyridine derivatives

Synthesis of a novel heterocyclic scaffold utilizing 2-cyano-N-(3-cyano-4,6-dimethyl-2-oxopyridin-1-yl) acetamide

Synthesis and Antioxidant Activity of 6-Imino-4-(Methylthio)-2-(Pyridine-3-Yl)-6h-1,3-Thiazine-5-Carbonitrile

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