Reactions of tris(2‐pyridyl)phosphine oxides with electrophiles: Formation of 5‐substituted 2,2′‐bipyridyls

Abstract

The reaction of tris(2-pyridyl)phosphineoxides with benzeneselenenyl chloride in methanol gave the corresponding 5

Relativistic heavy atom effect on the 31P NMR parameters of phosphine chalcogenides. Part 1. Chemical shifts

“…As an example, they are used in asymmetric metal complex catalysis and represent the promising bifunctional homogeneous complexes for the oxidative catalysis. Phosphine chalcogenides are well known to be biologically active compounds possessing antibacterial, antitumor, and hepatotoxic activity and are widely used as building blocks in modern organic synthesis …”

Benzenesulfenyl Chloride

“…93 This process was made catalytic through the use of N-tert-butylbenzenesulfenamide with N-chlorosuccinimide as a stoichiometric chlorinating agent. 96 Tris-(2pyridyl) phosphine oxide undergoes ligand coupling by treatment with PhSCl affording the corresponding 5-substituted 2,2bipyridyls and 2,2 -bipyridyls. In addition, it was noted that the reaction effectively promoted the oxidation of primary alcohols in the presence of secondary alcohols, albeit in slightly lower yields of 69-72%.…”