Reactions of sulfoxides with reactive oxygen species to reveal the radical chemistry of pollution-derived particulate matter

Abstract

The radical reactions of dimethylsulfoxide (DMSO) and tetrahydrothiophene-1-oxide (THTO) with reactive oxygen species (ROS) in the presence of a nitroxide radical scavenger have been evaluated both synthetically and in analytical...

Synthesis of Anti-oxidant Steroids by Hybridisation with Nitroxides

“…57 We anticipated that this approach may result in side products, due to possible reactivity of the steroid side chain with some of the highly reactive species that are generated. 58 Interestingly, subjection of N1 – 4 to the generalised protection method was very efficient in producing the desired methoxyamines M1 – 4 , with no side products observed (Scheme 3 ). The absence of paramagnetic broadening allows us to use NMR spectroscopy to characterise the full structure and, in doing so, the structure of the parent steroidal–nitroxide hybrid (Figure 4 ).…”