Reactions of oxygen free radicals with copper complexes in pyridine: differentiation between superoxide and hydroxyl radicals

Haseloff, Reiner F.; Ebert, Bernd; Wischnewsky, Gerd G.

doi:10.1016/s0003-2670(00)82564-7

Cited by 19 publications

(10 citation statements)

References 15 publications

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“…These observations have been confirmed and extended by others using electron spin resonance and NBT reduction in hydroxyl radical generating systems [35], CL of either non-stimulated [26] or phorbol diester stimulated [37] human PMNLs, as well as hematoporphorin and light stimulated systems [36]. Stimulation of CL with still higher concentrations of tetrakis-g-salicylatodicopper(II) [Cu(II)2(salicylate)2 ] [26] can be attributed to the myeloperoxidase-mimetic activity of this complex and not an assumed deleterious effect [26] of this complex.…”

Section: Inflamm Ressupporting

confidence: 78%

Modulation of polymorphonuclear leukocyte responsiveness by copper (II)2 (niflumate)4

et al. 1995

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Antiinflammatory activities and modulations of PMNL responses produced by treatment with tetrakis-mu-2-[3-(trifluoromethyl)-phenyl]aminonicotinatodicopper (II) [Cu(II)2(niflumate)4] and niflumic acid were studied in isologous serum-induced rat pleurisy. Doses of 10 or 30 mg/kg (35 or 106 mumol/kg) of niflumic acid or Cu(II)2(niflumate)4 (8 or 23 mumol/kg) caused significant (p < 0.01) reductions in pleural exudate and number of polymorphonuclear leukocytes (PMNLs) in the exudate. While both doses of Cu(II)2(niflumate)4 produced significant dose-related reductions in both parameters, only the higher dose of niflumic acid produced a significant dose-related reduction in both parameters. Boyden chamber measurements of N-formyl-methionyl-leucyl-phenylalanine (f-MLP) chemotaxis by PMNLs incubated with 10 or 30 micrograms/ml niflumic acid (35 or 106 nmol/ml) or Cu(II)2(niflumate)4 (8 or 23 nmol/ml) were significantly (p < 0.01 to p < 0.001) decreased in dose-related fashions. Chemotaxis of PMNLs from pleuritic rats treated orally with 10 or 30 mg/kg niflumic acid or Cu(II)2(niflumate)4 was significantly (p < 0.001) inhibited by the larger dose of niflumic acid and both doses of Cu(II)2(niflumate)4. Opsonized zymosan (OZ)-stimulated chemiluminescence (CL) of PMNLs from pleuritic rats treated orally with these same doses of niflumic acid or Cu(II)2(niflumate)4 was only significantly (p < 0.05 or p < 0.01 respectively) decreased by the larger doses. Superoxide (O2-) production by these cells was significantly decreased by the larger dose of niflumic acid (p < 0.05) while both doses of Cu(II)2(niflumate)4 produced significant (p < 0.05 to p < 0.01) decreases.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Inflamm Ressupporting

confidence: 78%

Modulation of polymorphonuclear leukocyte responsiveness by copper (II)2 (niflumate)4

et al. 1995

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“…A possible screening strategy at the molecular and cellular level is outlined in this study and in our previous paper (Haseloff et al, 1991). Low-molecular-weight copper complexes interact with oxygen radicals.…”

Section: Discussionmentioning

confidence: 95%

Reactions of copper complexes with oxygen radicals generated by human neutrophils

Haseloff

Grüner

Wischnewsky³

1992

J. Biolumin. Chemilumin.

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The intensity of the chemiluminescence of unstimulated human neutrophils in the presence of luminol was used to investigate the effects of low-molecular-weight copper complexes at the cellular level. In different models (superoxide dismutase mimetic activity, inhibition of haematoporphyrin derivative/light-induced lysis of cells), the biological activity of the complexes exceeded the activity of the ligands alone.

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“…Most techniques for the detection of superoxide radical have used indirect spectroscopic methods, 52 such as spectrophotometric measurement, 53 chemiluminescence method, 54 and electron spin resonance spectroscopy. 55 However, these means are ex situ detection techniques with poor selectivity or sensitivity.…”

Section: ·2 Application To Biosensing Of Metabolismic Materials Inmentioning

confidence: 99%

Electrochemical Biosensors in Nonaqueous Solutions and Their Applications

Nakamura

2007

ANAL. SCI.

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This review first describes the invention of functional interfaces to promote biochemical redox reactions between substrates in dipolar aprotic solvents and enzymes or related compounds immobilized at the interface. The interfaces contain hydrophilic polymer membranes, a gold nanoparticle self-assembled electrode constructed by using rigid rod dithiols, and binary self-assembled monolayers composed of amino and carboxyl terminal groups. Other topics covered are: the electrochemical characterization of the hydrophilic polymer membrane; the development of biosensors to obtain reaction parameters of enzymatic and of electrochemical kinetics; and applications to the study of materials involved in metabolism.

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Reactions of oxygen free radicals with copper complexes in pyridine: differentiation between superoxide and hydroxyl radicals

Cited by 19 publications

References 15 publications

Modulation of polymorphonuclear leukocyte responsiveness by copper (II)2 (niflumate)4

Modulation of polymorphonuclear leukocyte responsiveness by copper (II)2 (niflumate)4

Reactions of copper complexes with oxygen radicals generated by human neutrophils

Electrochemical Biosensors in Nonaqueous Solutions and Their Applications

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