Reactions of N"-acyl- and N"-tosyl-substituted hydrazides of 2-aminobenzoic acid with carbonyl compounds

Crystal Structure of 2-thiophene-2-yl-3(thiophene-2-carboxylideneamino)-1, 2-dihydroquinazolin-4(3H)-one and the Synthesis, Spectral and Thermal Studies of its Transition Metal(II) Complexes

“…The plane II and Plane III make dihedral angles 81.20 and 66.94°with plane IV respectively whereas plane II and plane III are at an angle of 78.66°. These dihedral angles formed between different planes reveals that, the whole molecule is not planar.The angles around C(8) [the pyrimidine nucleus are in good agreement with the reported values in analogous compound[5]. The average bond distances and angles in the phenyl ring [plane II] of the quinazoline moiety are 1.386 Å and 120.0°respectively.…”

“…Many of them have been widely investigated for their therapeutic uses especially for anticancer [1], anti HIV [2], anti-inflammatory [3] and CNS depressant [4] activities. Particularly 1,2-dihydroquinazolin-4(3H)-one derivatives are known to be anticonvulsive and sedative agents [5].…”

“…Looking into the wide variety of pharmacological activities of quinazolines [1][2][3][4][5], the varied behavior of the ring sulphur of thiophene in different ligand environment [10,11] and the role of metal ion in enhancement of pharmacological activity [11,12], we aim to search for a new 1,2-dihydroquinazoline (1) with R=2-thienyl, containing potential pharmacophores and coordinating sites towards transition metal ions. In continuation of our earlier studies on transition metal(II) complexes of 1,2-dihydro quinazolin-4(3H)-one [6], here we report the synthesis and characterization of the title ligand and its manganese(II), cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes by various spectral (u.v.-vis., i.r., 1D n.m.r., 2D hetcor and e.p.r.)…”

Synthesis of 2-Amino-N′-aroyl(het)arylhydrazides, DNA Photocleavage, Molecular Docking and Cytotoxicity Studies against Melanoma CarB Cell Lines

“…The attachment of Anthranilic acid DACHZs (AA DACHZs, Figure 2, G, H) bear an additional functional amine group which contributes to their chemistry, biology and technology. Derivatives such as G may give rise to 1,3,4-oxadiazoles [7][8][9][10], 1,2,3-benzotriazine-4-ones [11], 3-amido-1,2dihydro substituted quinazolinones [12][13][14][15][16][17], 3-amido substituted quinazolinones [10,18], quinazolinone containing fused polycyclic compounds [19,20] or N-N axially chiral 3,3 ′bisquinazolinones [21]. Furthermore, their well-positioned electron-donating atoms allow metal complexation which, depending on the metal and the conditions applied, range from the formation of simple metal complexes [22][23][24] to the important metal-organic macrocycles (MOMs) [25,26] with Mn, Ga and In [27][28][29].…”

An environmentally friendly approach for the synthesis of quinazolinone sulfonamide

“…Among the reported methods for the synthesis of sulfonamides [47][48][49][50][51][52], the reaction of amino compounds and sulfonyl chlorides is still the most common method to access sulfonamide derivatives.…”