Reactions of methyl, hydroxyl and peroxyl radicals with the DOTA chelating agent used in medical imaging

Reaction of FeaqII with Peroxymonosulfate and Peroxydisulfate in the Presence of Bicarbonate: Formation of FeaqIV and Carbonate Radical Anions

“…It is known that SO 4 •– reacts with (CH 3 ) 2 SO to form methyl radicals via reaction However, also, other radicals react with (CH 3 ) 2 SO to form methyl radicals. , The formed methyl radicals (CH 3 • ) (reaction ) react to form ethane and methane via reactions –. , …”

“…It is known that SO 4 •– reacts with (CH 3 ) 2 SO to form methyl radicals via reaction false( CH 3 false) 2 SO + SO 4 • − → CH 3 • + CH 3 normalS ( O ) OSO 3 − However, also, other radicals react with (CH 3 ) 2 SO to form methyl radicals. , The formed methyl radicals (CH 3 • ) (reaction ) react to form ethane and methane via reactions –. , CH 3 • + false( CH 3 false) 2 SO → CH 4 + CH 2 ( CH 3 ) SO • , 0.25em k 21 = 100 0.25em normalM − 1 0.25em normals − 1 …”

“… 60 However, also, other radicals react with (CH 3 ) 2 SO to form methyl radicals. 60 , 61 The formed methyl radicals (CH 3 • ) ( reaction 21 ) react to form ethane and methane via reactions 21 – 23 . 46 , 62 …”

Effect of metal complexation on the radiolytic stability of DOTA

“…In a recent study, Avraham et al investigated the chemical reactions and changes that DOTA can undergo in response to radicals formed by the ionizing radiation induced by the radiometal. 37 The reaction of DOTA with HO˙, H 3 C˙ and H 3 CO 2 ˙ radicals was investigated. Hydroxyl radicals were shown to react significantly faster than methyl radicals.…”

“…[32][33][34][35] Very few studies are available on DOTA radiolysis. 36,37 The alpha radiolysis of DOTA was investigated in aqueous solution under helium ion irradiation. This led to the formation of molecular hydrogen (H 2 ) and carbon dioxide (CO 2 ).…”