Reactions of low-valent transition-metal complexes with hydrogen peroxide. Are they "Fenton-like" or not? 1. The case of Cu+aq and Cr2+aq

p53-Dependent Apoptotic Mechanism of a New Designer Bimetallic Compound Tri-phenyl Tin Benzimidazolethiol Copper Chloride (TPT-CuCl2): In Vivo Studies in Wistar Rats as Well as in Vitro Studies in Human Cervical Cancer Cells

“…It has been reported that Cu 2ϩ ions specifically bind to N-7 guanine residue of DNA and cause strand breakage (Sagripanti and Kraemer, 1989). The kinetic analysis (Goldstein and Czapski, 1986;Masarwa et al, 1988) of copper*DNA interaction and its site-specific binding to DNA have been well documented (Chevion, 1988;John and Douglas, 1989). Copper binding site on DNA serves as a center for repeated production of reactive oxygen species (ROS).…”

Novel Antiviral Characteristics of Nanosized Copper(I) Iodide Particles Showing Inactivation Activity against 2009 Pandemic H1N1 Influenza Virus

“…There are numerous reports on virus inactivation by the photocatalytic properties of TiO 2 , which also generates ·OH by the oxidation of H 2 O (7,12,13,21). On the other hand, Cu ϩ probably participates in a Fenton-like reaction to produce ·OH from hydrogen peroxide (16) Similarly, Cu ϩ dissolved from CuI in water or Cu ϩ existing on the surface of CuI may be oxidized back to Cu 2ϩ with the subsequent formation of hydrogen peroxide via the superoxide intermediate.…”

“…It has been reported that Cu ϩ in aqueous solution might behave as a catalyst in a Fenton-like reaction (16), leading to the generation of ·OH. ESR measurement using a spin trap DMPO, which is widely used in ESR spectroscopy, was performed to investigate whether CuI generates ·OH.…”

Nitroxide stable radicals protect beating cardiomyocytes against oxidative damage.

“…and/or be oxidized to higher oxidation states of the metal (25) LM(n-l)+ -H202 L-M(n+l)+ + 20H-. (4) According to this mechanism, the damage caused by OH radicals or hypervalent metals is site-specific; therefore, scavengers of OH radicals would not be expected to provide protection.…”