Reactions of Divalent Palladium with Ethylenediaminetetraacetic Acid

Effective Intratumoral Retention of [103Pd]AuPd Alloy Nanoparticles Embedded in Gel‐Forming Liquids Paves the Way for New Nanobrachytherapy

“…After synthesis of the [ 103 Pd]AuPdNPs, ethylenediaminetetraacetic acid (EDTA) was added as scavenger to complexate free Pd 2+ in order to avoid unspecific labeling of the NP surface. [ 50 ] Such radioactivity could potentially be released from the implanted nanogels, which is undesirable. During chemical development, some exploratory studies were conducted using analogous non‐radioactive AuPdNPs with similar Pd content.…”

Palladium‐Mediated Direct Disulfide Bond Formation in Proteins Containing S‐Acetamidomethyl‐cysteine under Aqueous Conditions

“…For this purpose we prepared the model peptide 1 (LYRAGC(Acm)LYRAG) and treated it with 10 equiv PdCl 2 for 5 min for Acm removal followed by incubation with various potential Pd chelators that cannot reduce disulfide bonds. This list includes 1) DTT as a reference reaction,, 2) dimethylglyoxime (DMG), 3) ethylenediaminetetraacetic acid (EDTA), 4) potassium iodide (KI), and 5) DTC . The reactions were analyzed using HPLC and mass analysis, and we found that the peptide was not recovered upon incubation for 25 min with DMG, EDTA, or KI (Figure B–D), probably due to inability to release the thiolate group from Pd.…”

Separation of Platinum, Palladium, Rhodium, and Iridium by Paper Electrochromatography

“…Effect of Concentration of (Ethylenedinitrilo) tetraacetic Acid in Solvent. It was expected that (ethylenedinitrilo)tetraacetic acid would have more effect upon palladium and iridium than upon platinum and rhodium, as MacNevin and Kriege showed (4,6,8,9) that complexation occurs, readily with the first two. To determine the effect of concentration of the complexing agent, a pH of 7 was selected, for the experiments because the palladium complex is stable under these conditions.…”

“…Previous separation of these metals by chromatography has been carried out in acid solution (1), in order to prevent precipitation of palladium, rhodium, and iridium, the three metals of the group that precipitate easily as hydroxides. MacXevin and Kriege (4, [6][7][8][9] have shown that palladium and iridium form soluble complexes with (ethylenedimtrilo)tetraacetic acid (Versene) in the presence of much chloride and in both acid and alkaline solution. It was expected that (1) the formation of these complexes in alkaline solution would allow further differentiation of the migration behavior of these four ions, (2) the use of alkaline solutions would change the rate of platinum migration as conversion from PtCle to Pt(OH)e progressed with increasing pH, and (3) rhodium would not migrate at all in alkaline solution, because it forms an insoluble hydroxide, does not complex with (ethylenedinitrilo)tetraacetic acid during the experiment, and would therefore remain at the point of application.…”