Reactions of 2,2‐Dimethylaziridine‐Type Alkylating Agents in Biological Systems II: Comparative Pharmacokinetics in Dogs

A Convenient Method for Estimating the Quantity of Drug Eliminated by the Routes Other than Hepatic Metabolism and Renal Excretion and the Fraction of Drug that Reaches the “First Pass” after Oral Administration

“…Some earlier estimations of the quantity of peripherally eliminated drug were done based on a two compartment model with elimination rates from both the central and peripheral compartments 3…”