Reactions in Droplets in Microfluidic Channels

Song, Helen; Chen, Delai L.; Ismagilov, Rustem F.

doi:10.1002/anie.200601554

Cited by 1,697 publications

(1,299 citation statements)

References 255 publications

Supporting

Mentioning

1,274

Contrasting

Unclassified

Order By: Relevance

“…51 Therefore, the local radius of curvature is smaller at the point of coalescence for smaller droplets. For isolated droplet pairs in a four-roll mill device, Hu et al show that the critical capillary number decreases with increasing droplet radius according to equation (1). 19 We compare our observations with this scaling argument by measuring the local curvature of the approaching droplets at the point of coalescence.…”

Section: Critical Capillary Number For Coalescencementioning

confidence: 57%

See 1 more Smart Citation

Coalescence and splitting of confined droplets at microfluidic junctions

et al. 2009

View full text Add to dashboard Cite

The ability to merge two droplets is an important component of droplet-based lab-on-a-chip devices, yet flow-induced coalescence is difficult to achieve due to long film drainage times compared with relatively short residence times. We examine droplet collisions at a simple microfluidic T-junction and characterize the response for a wide range of droplet sizes and speeds. We find that three primary responses occur, where coalescence occurs easily at low collision speeds, smaller droplets traveling faster slip past one another without coalescing, and larger and faster droplets can break one another into multiple segments. The critical capillary number for coalescence agrees well with previously reported scaling for isolated droplet pairs when local curvature and speed are taken into account. The critical capillary number for splitting of droplets agrees well with a previously reported stability condition for individual droplets stretching in an extensional flow. Quantifying the necessary conditions for coalescence and non-coalescence behavior should enable the informed design of lab on chip devices based on discrete liquid segments.

show abstract

Section: Critical Capillary Number For Coalescencementioning

confidence: 57%

“…4 In order to realize successful droplet-based devices, multiple ''unit operations'' must be combined and integrated, including generation of droplets, 4,5 fission, 6 sorting, 7 and mixing within droplets. 1,7 In addition, the ability to merge two droplets with different contents is critical to the success of these devices.…”

Section: Introductionmentioning

confidence: 99%

Coalescence and splitting of confined droplets at microfluidic junctions

et al. 2009

View full text Add to dashboard Cite

show abstract

“…The approaches described in this work address many of the fluid-handling challenges that are faced when working with microfluidic devices [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] including those involving laminar flow, 22,38 droplets, 21,[39][40][41] and cell culture experiments. [42][43][44] The simplicity of this pumping method overall and the use of the guiding structures make it robust to differences in pushing/pulling force; the user simply places a sample at the inlet and then pushes/pulls the pumping lid to generate the flow.…”

Section: Discussionmentioning

confidence: 99%

The pumping lid: investigating multi-material 3D printing for equipment-free, programmable generation of positive and negative pressures for microfluidic applications

et al. 2014

Self Cite

View full text Add to dashboard Cite

Equipment-free pumping is a challenging problem and an active area of research in microfluidics, with applications for both laboratory and limited-resource settings. This paper describes the pumping lid method, a strategy to achieve equipment-free pumping by controlled generation of pressure. Pressure was generated using portable, lightweight, and disposable parts that can be integrated with existing microfluidic devices to simplify workflow and eliminate the need for pumping equipment. The development of this method was enabled by multi-material 3D printing, which allows fast prototyping, including composite parts that combine materials with different mechanical properties (e.g. both rigid and elastic materials in the same part). The first type of pumping lid we describe was used to produce predictable positive or negative pressures via controlled compression or expansion of gases. A model was developed to describe the pressures and flow rates generated with this approach and it was validated experimentally. Pressures were pre-programmed by the geometry of the parts and could be tuned further even while the experiment was in progress. Using multiple lids or a composite lid with different inlets enabled several solutions to be pumped independently in a single device. The second type of pumping lid, which relied on vapor-liquid equilibrium to generate pressure, was designed, modeled, and experimentally characterized. The pumping lid method was validated by controlling flow in different types of microfluidic applications, including the production of droplets, control of laminar flow profiles, and loading of SlipChip devices. We believe that applying the pumping lid methodology to existing microfluidic devices will enhance their use as portable diagnostic tools in limited resource settings as well as accelerate adoption of microfluidics in laboratories.

show abstract

“…They also reduce the risk of fouling by wetting the channel surface and therefore provide a high level of control of the synthesis conditions. [50,227] Either liquid-liquid/gas-liquid segmented flow microreactors or droplet-based microreactors can be used for this purpose. [52] Reagents can be highly localized by virtue of these immiscible fluids in both commercial and laboratory systems.…”

Section: Segmented Flow (Multiphase) Microreactorsmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

View full text Add to dashboard Cite

In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

show abstract

Reactions in Droplets in Microfluidic Channels

Cited by 1,697 publications

References 255 publications

Coalescence and splitting of confined droplets at microfluidic junctions

Coalescence and splitting of confined droplets at microfluidic junctions

The pumping lid: investigating multi-material 3D printing for equipment-free, programmable generation of positive and negative pressures for microfluidic applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Contact Info

Product

Resources

About