Reactions de wittig, wittig-horner et knoevenagel par activation anionique avec l'alumine ou le fluorure de potassium depose sur l'alumine, sans solvant

Texier‐Boullet, Françoise; Villemin, Didier; Ricard, Michele; Moison, H.; Foucaud, A.

doi:10.1016/s0040-4020(01)96527-5

Cited by 84 publications

(21 citation statements)

References 43 publications

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“…It has been reported that KF-loaded alumina (KF/ Al 2 O 3 ) shows an efficient solid base catalyst for promoting versatile chemical transformations, such as the Micheal addition, N-, O-and S-alkylation reactions, the Knoevenagel condensation, aldol condensation, Witting-Horner reactions and alkene isomerization [13][14][15][16][17][18][19]. To the best of our knowledge, there is no open literature concerning the solid base of ZnO loaded with KF (KF/ ZnO).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Biodiesel from Soybean Oil using Heterogeneous KF/ZnO Catalyst

2006

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Biodiesel was produced by transesterification of soybean oil with methanol using ZnO loaded with KF as a solid base catalyst. It was found that the catalyst with 15 wt.% KF loading and calcined at 873 K showed the optimum activity. XRD, IR and Hammett indicator method were employed for the catalyst characterization. The results showed the activity of the catalysts was correlated with their basicity. The influence of various reaction variables on the conversion was also discussed.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Biodiesel from Soybean Oil using Heterogeneous KF/ZnO Catalyst

2006

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“…However, use of alumina [10] allowed us to prepare the corresponding alcohols 19 and 20aϪc under very practical conditions and in appreciable yields (56Ϫ60%). These alcohols were all obtained as mixtures of two diastereomers in 50:50 ratios.…”

Section: Knoevenagel Adducts From the Reactions Between Glutaconate Mmentioning

confidence: 99%

Knoevenagel Adducts from Reactions between Glutaconate Moieties and Aldehydes and Their Adducts with Primary Amines and Enamines

et al. 2003

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Evaluation of an hypothesis regarding the biomimetic synthesis of manzamine alkaloids from the stepwise condensation of malonate, aldehydes and primary amine derivatives is presented. The first part of this study was concentrated on the Knoevenagel reaction, with various aldehydes, of glutaconaldehydes 7 and their ester analogues 17 and 23, in order to prepare stable derivatives of dienes 8. This reaction, previously reported to work only with salicylaldehyde and glutaconic esters, appeared to be difficult to control in the case of the glutaconaldehyde derivative 7a, but was successful when starting from esters 17 and 23. This result allowed the preparation of new dienes 21, 22a−c, and 25. The second part of this paper reports preliminary results concerning the reactivity of diene 21 towards primary amines and aldehyde equiva-

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“…Therefore, the w-bromoalkyl derivatives 33 and 34 were prepared by reacting 28 with an excess of the suitable oligomethylene dibromide in the presence of KF/Al 2 O 3 prepared according to Texier ± Boullet et al [30] (Method B). This procedure has been used before by Mokrosz et al [23] and by us [14] for the preparation of 1-and 2-(4-bromobutyl)benzotriazole.…”

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confidence: 99%

“…Data of 2-(5,6-Dimethoxy-1H-1,2,3-benzotriazol-1-yl)ethanol (29a (30 g) [30] were added. The mixture was refluxed for 2 h, and then stirred overnight at r.t.…”

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α1- andα2-Adrenoreceptor Antagonist Profiles of 1- and 2-[ω-(4-Arylpiperazin-1-yl)alkyl]-1,2,3-benzotriazoles

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Budriesi

Boido

et al. 2005

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A series of pharmacologically interesting 1- and 2-[omega-(4-arylpiperazin-1-yl)alkyl]-1,2,3-benzotriazoles, compounds 1-27, were synthesized (Scheme) and subjected to various biological studies to identify structure-activity relationships (SAR). The new compounds were found to exhibit good non-selective binding affinity towards the alpha1-adrenoreceptor (Table 1). In several cases, high functional antagonism was observed towards the alpha1A-, alpha1B-, and alpha1D-adrenoreceptor subtypes (Table 2). The selectivity for these three subtypes was comparable with or superior to that displayed by the standard drug prazosin. The most-common selectivity rank order was alpha1D > alpha1B > alpha1A, followed by alpha1B > alpha1D > alpha1A. In functional experiments, antagonism towards the alpha2-adrenoreceptor was generally low; however, a few compounds were endowed with significant antagonist properties (pA2 values of up to 7.87).

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Reactions de wittig, wittig-horner et knoevenagel par activation anionique avec l'alumine ou le fluorure de potassium depose sur l'alumine, sans solvant

Cited by 84 publications

References 43 publications

Synthesis of Biodiesel from Soybean Oil using Heterogeneous KF/ZnO Catalyst

Synthesis of Biodiesel from Soybean Oil using Heterogeneous KF/ZnO Catalyst

Knoevenagel Adducts from Reactions between Glutaconate Moieties and Aldehydes and Their Adducts with Primary Amines and Enamines

α1- andα2-Adrenoreceptor Antagonist Profiles of 1- and 2-[ω-(4-Arylpiperazin-1-yl)alkyl]-1,2,3-benzotriazoles

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