Reaction with DNA and pharmacologic activity of 1,10-phenanthroline and electron-rich 1,10-phenanthrocyanine complexes of d-elements

Demidov, V. N.; Kasyanenko, N. A.; Антонов, В. Г.; Volkov, Ivan L.; Sokolov, P. A.; Pakhomova, T. B.; Simanova, S. A.

doi:10.1134/s1070363212030401

Cited by 8 publications

(5 citation statements)

References 130 publications

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“…It is found that Pd(II) and Zn(II) PC have a trend to complex formation with calf thymus DNA [21,22].…”

Section: Biology Activity Of Pc Complexes Of D-elementsmentioning

confidence: 99%

“…Typical growth pat-terns are shown in Table 1. 7) with bridged electron-rich PC ligands [17,22]. Using such methods as electron absorption spectroscopy, uorescence, atomic force mic-roscopy, CD, low-gradient viscometry, gel electrophoresis, double refraction and DNA melting, co-mplexation between them is shown.…”

Section: Biology Activity Of Pc Complexes Of D-elementsmentioning

confidence: 99%

“…These compounds exhibit the properties of DNA complexones [21,22], have a cytostatic effect against tumor cells in vitro (proliferation inhibitors) and demonstrate the ability to inhibit the deve-lopment of pathogenic fungi (for example, in the case of Co(II)-containing compounds). The effec-tiveness of the effect of PCs of d-elements on biological objects depends on the nature of the comp-lexing agent metal.…”

Section: Introductionmentioning

confidence: 99%

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ESR Spectroscopy of Temperature Accessible Lowest Triplet States of Biology Active Electron-Rich 1,10- Phenanthrocyanines of d-Elements (Soft Colloidal Glasses)

Demidov

Sukharzhevsky

Pakhomova

et al. 2022

Preprint

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Temperature accessible lowest electronic triplet biradical states of new metal 1,10-phenanthrocyani-nes were investigated by ESR spectroscopy. These are coordination compounds of a new structural class of cyanines: nanosize chromophore binuclear cation complexes of d-elements [Mz+Ln(µ-PC)]2Xn (Mz+=Zn2+, Cd2+, Pd2+and Pt2+; L=1,10-phen, py, AcO-; X=AcO-, Cl-) with electron-rich 1,10-phenanthrocyanine ligands. They are presented as redox-sensitive polymorphic soft collo-idal glasses capable of acting as inhibitors of tumor cell proliferation, environmentally friendly fun-gicides and DNA complexones related with NADH. The study of them by ESR spectroscopy sho-wed that one of the possible detailed mechanisms of the formation of triplet states in the processes of thermo-directed singlet-triplet S0→Tlow.-transitions consists in thermally activation of rotation around the sesquialteral C—C bond dihydro-1,10-phenanthroline and 1,10-phenanthroline frag-ments in the bridged chromophore system of compounds.

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“…It is found that Pd(II) and Zn(II) PC have a trend to complex formation with calf thymus DNA [21,22].…”

Section: Biology Activity Of Pc Complexes Of D-elementsmentioning

confidence: 99%

Section: Biology Activity Of Pc Complexes Of D-elementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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ESR Spectroscopy of Temperature Accessible Lowest Triplet States of Biology Active Electron-Rich 1,10- Phenanthrocyanines of d-Elements (Soft Colloidal Glasses)

Demidov

Sukharzhevsky

Pakhomova

et al. 2022

Preprint

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“…The synthesis of different metal complexes with phenanthroline ligands and the study of their binding to the DNA molecule have been carried out [11][12][13][14][15][16][17]. Some metal ions play an essential role in different biochemical functions.…”

Section: Introductionmentioning

confidence: 99%

DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline

Kasyanenko,

Belyi,

Silanteva

et al. 2024

IJMS

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The experimental study of the DNA interaction with three cadmium coordination compounds [Cd(phen)3](CH3CO2)2, [Cd(phen)2(H2O)2](CH3CO2)2, and [Cd2(phen)4(H2O)2](CH3CO2)4 was carried out using spectrophotometry, viscosity, and dynamic light scattering methods. The role of the solution ionic strength (concentration of NaCl) was analyzed. All compounds can penetrate (fully or partly) to the major or minor DNA grooves. It was shown that, in addition to the important role of electrostatic interactions in the formation of the complex, intercalation of the 1,10-phenanthroline ligand occurs for compounds [Cd(phen)2(H2O)2](CH3CO2)2 and [Cd2(phen)4(H2O)2](CH3CO2)4. Compound [Cd(phen)3](CH3CO2)2 binds to DNA externally. The coordination bond between cadmium and DNA was formed in DNA complexes with [Cd2(phen)4(H2O)2](CH3CO2)4. Preliminary computer modeling of the DNA interaction with the compounds used was performed.

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“…It was mentioned that complexes of metals with 1,10-phenanthrolines interact with DNA as intercalators [ 39 , 40 ]. They can also be connected to DNA via the coordination bonds [ 41 ]. It was shown that 1,10-phenanthrolines in complexes with redox active metals, e.g., Cu(II)/Cu(I), Co(II)/Co(III), Fe(II)/Fe(III), can participate in oxidative damage of DNA [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

DNA Binding with Acetate Bis(1,10-phenanthroline)silver(I) Monohydrate in a Solution and Metallization of Formed Structures

et al. 2017

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Abstract:The study of DNA interaction with the acetate bis(1,10-phenanthroline)silver(I) monohydrate in a solution is of interest both for understanding the mechanism of biological activity of silver compound and for forming ordered structures (DNA fibrils) that can be used to solve various problems in the field of nanotechnology. The analysis of changing the DNA conformation (secondary structure, persistent length and volume effects) during the interaction by the methods of UV spectroscopy with the analysis of DNA melting, circular dichroism, viscosity, flow birefringence, AFM (atomic force microscopy) and SEM (scanning electron microscopy) was performed. The formation of two types of complexes was observed. At lower concentration of compound in DNA solution, silver atoms form the coordination bonds with a macromolecule, while the released phenanthroline ligands intercalate between DNA bases. When the concentration of the compound increases, the phenanthroline ligands form an ordered "layer" around the helix. The excess of silver compounds in the DNA solution (with more than five silver atoms per base pair), DNA precipitation is observed with the formation of long fibrils. It was shown that the binding of silver to DNA during the formation of complexes provides further metallization of the resulting structures with the aid of reducing agents; phenanthroline ligands influence the result of such metallization.

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Reaction with DNA and pharmacologic activity of 1,10-phenanthroline and electron-rich 1,10-phenanthrocyanine complexes of d-elements

Cited by 8 publications

References 130 publications

ESR Spectroscopy of Temperature Accessible Lowest Triplet States of Biology Active Electron-Rich 1,10- Phenanthrocyanines of d-Elements (Soft Colloidal Glasses)

ESR Spectroscopy of Temperature Accessible Lowest Triplet States of Biology Active Electron-Rich 1,10- Phenanthrocyanines of d-Elements (Soft Colloidal Glasses)

DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline

DNA Binding with Acetate Bis(1,10-phenanthroline)silver(I) Monohydrate in a Solution and Metallization of Formed Structures

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