Reaction to Sodium Diphenyl Hydantoinate (Dilantin Sodium)

Ritchie, Earl B.

doi:10.1001/archderm.1942.01500180078012

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1946

1985

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Cited by 38 publications

(3 citation statements)

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“…Gropper (1956) described a 29-year-old man who developed jaundice, exfoliative dermatitis, eosinophilia, and lymphadenopathy; terminally ulceration extended to include lips, eyes, oral cavity, and genitalia. Ritchie and Kolb (1942) described a fatal case of haemorrhagic erythema. Necropsy showed extensive haemorrhagic changes in the skin, mouth, and gastrointestinal tract, and pulmonary oedema and oedema of the brain.…”

Section: Discussionmentioning

confidence: 99%

Severe cutaneous reactions to phenytoin.

Kp¹

1973

Archives of Disease in Childhood

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Section: Discussionmentioning

confidence: 99%

Severe cutaneous reactions to phenytoin.

Kp¹

1973

Archives of Disease in Childhood

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“…Cutaneous reactions following the ingestion of hydantoin derivatives are commonly erythematous, scarlatiniform, or morbilliform in character. The eruption tends to appear about the ninth or tenth day of treatment, and may be accompanied by fever (Ritchie and Kolb, 1942). The incidence of such reactions is reported to be between 5% and 10% of patients taking phenytoin, and at least 5% of' those receiving methoin (Bailey et al, 1965;Lindmayr, 1951).…”

mentioning

confidence: 99%

“…A rarer manifestation of hydantoin sensitivity is exfoliative dermatitis (Ritchie and Kolb, 1942). Gropper (1956) reported a fatal case associated with hepatitis.…”

mentioning

confidence: 99%