Reaction Time and Prognosis in Acute Schizophrenia

Cancro, Robert; Sutton, Samuel; Kerr, Joyce L.; Sugerman, A. Arthur

doi:10.1097/00005053-197111000-00009

Cited by 67 publications

(36 citation statements)

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“…Indeed, reaction time was described as the “closest thing to a north star of schizophrenia research” (Cancro et al, 1971). Many studies examined cued reaction time tests in which subjects received trials with regular and irregular intervals between a warning signal (instructing the subject to get ready) and the imperative stimulus (instructing the subject to respond).…”

Section: Where We Came Frommentioning

confidence: 99%

Cognition in schizophrenia: Past, present, and future

Green¹,

Harvey

2014

Schizophrenia Research: Cognition

219

152

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Schizophrenia Research: Cognition will serve an important function – a place where interests converge and investigators can learn about the recent developments in this area. This new journal will provide rapid dissemination of information to people who will make good use of it. In this initial article, we comment globally on the study of cognition in schizophrenia: how we got here, where we are, and where we are going. The goal of this first article is to place the study of cognition in schizophrenia within a historical and scientific context. In a field as richly textured as ours it is impossible to hit all the important areas, and we hope the reader will forgive our omissions. Phrased in cognitive terms, our limited presentation of the past is a matter of selective memory, the present is a matter of selective attention, and the future is a matter of selective prospection. This broad introduction emphasizes that cognition in schizophrenia provides clues to pathophysiology, treatment, and outcome. In fact, the study of cognitive impairment in schizophrenia has become wholly intertwined with the study of schizophrenia itself.

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Section: Where We Came Frommentioning

confidence: 99%

Cognition in schizophrenia: Past, present, and future

Green¹,

Harvey

2014

Schizophrenia Research: Cognition

219

152

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“…1 What is more, slowing of psychomotor function in schizophrenic patients was demonstrated to be a predictor of poor prognosis and poorer clinical and functional outcome. [2][3][4][5][6][7] Although many clinical studies focused on the effects of antipsychotic treatment on cognitive function, very few addressed the effects of these compounds on psychomotor speed. There are some reports in the literature that do describe impeding effects, but the findings are inconsistent, and, to our knowledge, only 1 study 8 was primarily aimed at the pharmacological effects on processing speed.…”

mentioning

confidence: 99%

Psychomotor and Memory Effects of Haloperidol, Olanzapine, and Paroxetine in Healthy Subjects After Short-Term Administration

Morrens¹,

Wezenberg²,

Verkes³

et al. 2007

Journal of Clinical Psychopharmacology

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“…In manual stimulus reaction tasks, poor results also correlate with an unfavourable prognosis (Cancro et al 1971;Zahn and Carpenter 1978). Since patients with long and unfavourable courses of illness have often been receiving neuroleptics for many years, the effects due to their chronic state upon saccadic reaction times cannot be separated completely from those of long-term neuroleptic medication.…”

Section: Discussionmentioning

confidence: 99%

Saccadic reaction times in acute and remitted schizophrenics

Mackert

Flechtner

1989

Eur Arch Psychiatr Neurol Sci

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Schizophrenics are known to have various disturbances of the visuomotor system. Whereas smooth pursuit eye movement disorders have been repeatedly confirmed, there are relatively few reports regarding possible disturbances of the saccadic system. In this study, the saccadic reaction times of 47 schizophrenic inpatients were investigated upon admission and later in the remitted state; 28 age- and sex-matched normal volunteers were tested as controls. Psychopathology and outcome were evaluated according to the Brief Psychiatric Rating Scale and the Prognostic Scale. Light stimuli were presented at random direction, location (ranging from 0 degrees to 20 degrees) and duration (800, 1000, and 1200 ms). The eye movements were recorded by electro-oculography. Compared with the control group, schizophrenics revealed prolonged saccadic reaction times, which correlated with pronounced negative symptoms and an unfavourable course of the illness. The saccadic reaction times remained prolonged in schizophrenic patients. These findings suggest attentional deficits in schizophrenics.

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Reaction Time and Prognosis in Acute Schizophrenia

Cited by 67 publications

References 0 publications

Cognition in schizophrenia: Past, present, and future

Cognition in schizophrenia: Past, present, and future

Psychomotor and Memory Effects of Haloperidol, Olanzapine, and Paroxetine in Healthy Subjects After Short-Term Administration

Saccadic reaction times in acute and remitted schizophrenics

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