Reaction of α, β-Unsaturated Carbonyl-Compounds with Thiourea

Five-Membered Heterocyclic Ring Via Dichalcones

“…After complete addition, the mixture stirred for (3 hrs) at room temperature, then after (24 hrs) the precipitate was filtered ,washed with water until the neutralization and recrystallized from ethanol. preparation of (3-alkyl-5-aryl-2-pyrazoline)(22-30) [14][15] In a round bottom flask fitted with magnetic stirrer dissolve (0.005 mol) of any double chalcone (4)(5)(6)(7)(8)(9)(10)(11)(12) , and add (0.05 mol ,0.05 g) of hydrazine hydrate with stirring for (6 hrs) at room temperature. Filter the produced precipitate and wash with water then recrystallize from ethanol.…”

“…In this study some of dichalcone compounds (4)(5)(6)(7)(8)(9)(10)(11)(12) were prepared by the reaction of benzalacetone and its derivatives with a number of different ketones (acetophenone, acetanilide, 2butanone). Also a number of heterocyclic compounds were prepared as a derivatives of that dichalcones, these derivatives were prepared by the reaction of dichalcone with hydrogen peroxide, hydrazine hydrate and urea to produce oxirane compounds (13)(14)(15)(16)(17)(18)(19)(20)(21), pyrazolines (22)(23)(24)(25)(26)(27)(28)(29)(30) and pyrimidinones (31-40) respectively. All the synthesised compounds were characterized by the available physical and spectral methods (melting point , I.R.…”