Reaction of radical cations with multilayers of tannic acid and polyelectrolytes

Shutova, T. G.; Agabekov, V. E.; Lvov, Yuri

doi:10.1134/s1070363207090034

Cited by 23 publications

(32 citation statements)

References 28 publications

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“…For gelatin/EGCG films, unlike that for tannic acid/polyallylamine multilayers [32,33], the value of W increases with increasing number of bilayers in the film and no plato is observed on the graph (Fig. 3b).…”

Section: Interaction Of Abts +• With Gelatin/egcg Multilayersmentioning

confidence: 49%

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(−)-Epigallocatechin gallate/gelatin layer-by-layer assembled films and microcapsules

Shutava

Balkundi

Lvov

2009

Journal of Colloid and Interface Science

107

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Section: Interaction Of Abts +• With Gelatin/egcg Multilayersmentioning

confidence: 49%

“…Polyphenols incorporated in LbL constructions can serve as a protective element against reactive free radical species in oxidizing media introducing additional antioxidant properties to the assemblies [32,33], thus prolonging their life-time and enhancing effectiveness of encapsulated substances.…”

Section: Introductionmentioning

confidence: 99%

(−)-Epigallocatechin gallate/gelatin layer-by-layer assembled films and microcapsules

Shutava

Balkundi

Lvov

2009

Journal of Colloid and Interface Science

107

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“…[77] Lvov, et al ., showed that antioxidant activity of TA is preserved in TA/polycation multilayers. [xli] He, et al ., reported that antioxidant stability of a drug formulation was improved when poly(triethylene glycol methyl acrylate-co-tocopheryl acrylate) complexed with TA was used as a potential antioxidant pro-drug to enable localized neuroprotection. [xlii] Recently, De Geest and co-workers encapsulated tumor associated antigen by conjugating cancer cells with (TA/PVPON) multilayers to be used for anticancer immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

Hydrogen‐Bonded Multilayers of Tannic Acid as Mediators of T‐Cell Immunity

Kozlovskaya

Xue

Lei

et al. 2014

Adv Healthcare Materials

100

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Type 1 diabetes is an autoimmune-mediated disease resulting in the destruction of insulin-secreting pancreatic β-cells. Transplantation of insulin-producing islets is a viable treatment to restore euglycemia in Type 1 diabetics, however, the clinical application remains limited due to the use of toxic immunosuppressive therapies to prevent immune-mediated rejection. We present a nanothin polymer material with dual antioxidant and immunosuppressive properties capable of modulating both innate and adaptive immune responses crucial for transplantation outcome. Through the use of hollow microparticles (capsules) comprising of hydrogen-bonded multilayers of natural polyphenol (tannic acid) with poly(N-vinylpyrrolidone) (TA/PVPON) and with poly(N-vinylcaprolactam) (TA/PVCL), pro-inflammatory reactive oxygen and nitrogen species are efficiently dissipated and the production of IFN-γ and TNF-α pro-inflammatory cytokines are attenuated by cognate antigen-stimulated autoreactive CD4+ T cells. Our results provide evidence that TA-containing capsules are efficacious in immunomodulation and may provide physical transplant protection and prevent diabetogenic autoreactive T cell responses. Future studies will determine if xeno- and allotransplantation with (TA/PVPON)- or (TA/PVCL)-coated pancreatic islets will decrease the risk of graft rejection due to attenuation of oxidative stress and IFN-γ, and restore euglycemia in Type 1 diabetics.

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“…[58][59][60] In order to design individual cell-compatible synthetic shells, we recently designed highly permeable, hydrogenbonded LbL coatings utilizing tannic acid (TA), and poly(Nvinylpyrrolidone) (PVPON), which result in coatings responsive under biologically and physiologically relevant conditions that are suitable for engineering cell surfaces while increasing cell viability. [61][62][63][64][65] In TA/PVPON systems, cell viability following encapsulation was increased to 79%, as opposed to merely 20% in conventional PSS/PAH systems. However, in the application of the LbL technique to cell surfaces, a precursor layer such as PEI was utilized to provide enhanced adhesion of the subsequent multilayers.…”

Section: Introductionmentioning

confidence: 99%

Truly Nonionic Polymer Shells for the Encapsulation of Living Cells

Carter

Drachuk

Harbaugh

et al. 2011

Macromolecular Bioscience

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Engineering surfaces of living cells with natural or synthetic compounds can mediate intercellular communication and provide a protective barrier from hostile agents. We report on truly nonionic hydrogen-bonded LbL coatings for cell surface engineering. These ultrathin, highly permeable polymer membranes are constructed on living cells without the cationic component typically employed to increase the stability of LbL coatings. Without the cytotoxic cationic PEI pre-layer, the viability of encapsulated cells drastically increases to 94%, in contrast to 20% viability in electrostatically-bonded LbL shells. Moreover, the long-term growth of encapsulated cells is not affected, thus facilitating efficient function of protected cells in hostile environment.

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Reaction of radical cations with multilayers of tannic acid and polyelectrolytes

Cited by 23 publications

References 28 publications

(−)-Epigallocatechin gallate/gelatin layer-by-layer assembled films and microcapsules

(−)-Epigallocatechin gallate/gelatin layer-by-layer assembled films and microcapsules

Hydrogen‐Bonded Multilayers of Tannic Acid as Mediators of T‐Cell Immunity

Truly Nonionic Polymer Shells for the Encapsulation of Living Cells

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