Reaction of Nitrite With Vitamins C and E

Tannenbaum, Steven R.; Mergens, William J.

doi:10.1111/j.1749-6632.1980.tb21345.x

Cited by 39 publications

(17 citation statements)

References 17 publications

(2 reference statements)

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“…2), with yT reducing NO2 to NO at a significantly greater rate than did a-T. It has been postulated that the ability of a-T to react with nitrosating agents to produce NO accounts for its ability to prevent nitrosation reactions (43,44). While limited NO formation by a-T under our reaction conditions was observed, yT was superior in this regard.…”

Section: Materials and Methods Chemicals Morpholine A-t And -T-t Scontrasting

confidence: 37%

“…a-T functions effectively as an inhibitor of lipid peroxidation and inhibits nitrosation when assessed in short-term assays (43,44,55); however, simultaneous formation of a nitrosating agent from reaction with NO2 suggests that long-term protection from genotoxic deamination reactions may be incomplete. This may explain enhanced tumor formation when a-T is administered to animals at high doses (17,18).…”

Section: Materials and Methods Chemicals Morpholine A-t And -T-t Smentioning

confidence: 99%

“…Two major sources of y-T, soybeans and corn, are known to produce nitrogen oxides (24,25 the nitrite ester of a-tocopherylquinone. Organic nitrite esters are potent nitrosating agents (39)(40)(41) and are not inhibited by a-T (42), although a-T is reported to block nitrosation by nitrous acid and nitrogen oxides (43,44). In contrast, it has been suggested that y-T may catalyze nitrosation reactions through formation of a C-nitroso intermediate (43,44), although this has not been verified experimentally.…”

mentioning

confidence: 96%

“…Organic nitrite esters are potent nitrosating agents (39)(40)(41) and are not inhibited by a-T (42), although a-T is reported to block nitrosation by nitrous acid and nitrogen oxides (43,44). In contrast, it has been suggested that y-T may catalyze nitrosation reactions through formation of a C-nitroso intermediate (43,44), although this has not been verified experimentally. In light of the occurrence of yT in plants and seeds, known to produce nitrogen oxides, and the demonstrated ability of a-T to form a nitrite ester, we sought to identify the relative reactivities of these tocopherol homologues with NO2 and the products formed in order to assess their role in nitrosation.…”

mentioning

confidence: 96%

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Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol.

Cooney

Franke

Harwood

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

309

180

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In the vitamin E group, a-tocopherol is generally considered to be the most potent antioxidant with the highest vitamin bioactivity, yet y-tocopherol is produced in greater amounts by many plants and Is the principal tocopherol in the United States diet. This report describes a fundamental difference in the chemical reactivities of a-tocopherol and y-tocopherol with nitrogen dioxide (NO2), which leads to the formation of a nitrosating agent from a-tocopherol, but not from y-tocopherol. Nitric oxide (NO) is a major product of the reaction of --tocopherol with NO2, while a-tocopherol reacts with NO2 to form an intermediate tocopheroxide analogue. The biological sgnificance of y-tocopherol is s d by m epidemiological data as well as the observation that it is a more potent inhibitor than a-tocopherol of neoplastic transformation during the postinitiation phase in 3-methylcholanthrenetreated C3H/10T½ murine fibroblasts. This latter property suggests the superiority of y-tocopherol in a mammalian biologcal assay and a role for endogenous NO production in promotion of neoplasic ransformation.

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Section: Materials and Methods Chemicals Morpholine A-t And -T-t Scontrasting

confidence: 37%

Section: Materials and Methods Chemicals Morpholine A-t And -T-t Smentioning

confidence: 99%

mentioning

confidence: 96%

mentioning

confidence: 96%

See 2 more Smart Citations

Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol.

Cooney

Franke

Harwood

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

309

180

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“…It is appreciated that epidemiological data have shown a mostly indirect association of vitamin C with cancers and with atherosclerosis and coronary heart disease (19-21), and Levine et al (3) point out that the 200 mg dose of ascorbic acid might prevent formation of harmful N-nitroso compounds in the gastrointestinal tract (22) and͞or produce a plasma concentration that might inhibit low density lipoprotein oxidation (23,24). Various experts have indicated that this latter function is largely speculative at this stage in our knowledge, at least with reference to the causation and progression of atherosclerosis in the U.S. population (19,(23)(24)(25).…”

Section: Relationship Between Proposed Rda and Diet Intakes In A Healmentioning

confidence: 99%

Evidence for a recommended dietary allowance for vitamin C from pharmacokinetics: A comment and analysis

Young

1996

Proc. Natl. Acad. Sci. U.S.A.

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The , based on a study of vitamin C pharmacokinetics in seven healthy men, have now proposed that the RDA should be increased to 200 mg daily. I have examined, in brief, the experimental and conceptual bases for this new recommendation and its implications for public health and nutrition policy and programs. Using, for illustrative purposes only, data extracted from each of two recent dietary surveys of noninstitutionalized adult males living in households in the Netherlands and the United States, it is predicted that the prevalence of intakes inadequate to meet the individual's own requirement would be about 96% or 84%, respectively, if the criteria of adequacy used for derivation of the 200 mg RDA are accepted. Depending upon the particular average requirement value for ascorbic acid that might be derived from their data, the proposal by Levine et al. would mean a desirable increase in mean intakes in these two populations by as much about 2-to 3-fold. Hence, before an action of this kind is to be recommended, an answer must be sought to the question whether current experimental data including the criteria selected (saturation kinetics) are adequate to establish a new set of requirements for vitamin C, which then carry such profound policy implications. This will require critical assessment of all of the available evidence emerging from laboratory, clinical, and epidemiological studies to determine whether it provides a sufficient rationale for accepting criteria of vitamin C adequacy such as those proposed by Levine et al. and the requirement estimates so derived.According to the 1989 report of the Food and Nutrition Board͞National Research Council (FNB͞NRC) (1), the recommended dietary allowances (RDAs) are ''the levels of intake of essential nutrients that, on the basis of scientific knowledge, are judged by the Food and Nutrition Board to be adequate to meet the known nutrient needs of practically all healthy persons.'' For adult men and women, the RDA for ascorbic acid was set at 60 mg per day, which was the same figure as had been proposed in the earlier 1980 report (2). According to the latter report (2), this value of 60 mg was based upon a consideration of (i) the observed rate of the turnover and rate of depletion of an initial body ascorbic acid pool of 1500 mg; (ii) an assumed absorption of ascorbic acid of about 85% at usual intakes; and (iii) the variable loss of ascorbic acid during food preparation. The last should not have been included, because as noted above, the RDA is meant to be an actual intake level rather than a dietary content. Nevertheless, it was predicted that this intake of 60 mg daily would prevent development of signs of scurvy for at least 4 weeks on a diet lacking vitamin C. Levine et al. (3) recently reported the results of a vitamin C depletion-repletion pharmacokinetic study in seven healthy men, which had been carried out to reexamine the RDA for vitamin C. They concluded that the RDA should be increased to 200 mg daily.The purpose of this discussion is to examine...

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Association between mothers' nutrient intake and their offspring's risk of gastroschisis

Torfs¹,

Lam²,

Schaffer

et al. 1998

Teratology

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Reaction of Nitrite With Vitamins C and E

Cited by 39 publications

References 17 publications

Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol.

Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol.

Evidence for a recommended dietary allowance for vitamin C from pharmacokinetics: A comment and analysis

Association between mothers' nutrient intake and their offspring's risk of gastroschisis

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