Reaction of N‐Aryl‐3‐oxobutanethioamides with 2‐Amino‐1,3‐thiazole and 2‐Amino‐1,3‐benzothiazole.

Abstract

Fused pyrimidine derivatives R 0515Reaction of N-Aryl-3-oxobutanethioamides with 2-Amino-1,3-thiazole and 2-Amino-1,3-benzothiazole. -Aryl-substituted oxobutanethioamides (I) react with binucleophiles (II) in a nonselective fashion. Mixtures of pyrimidines (III) and pyrimidinethiones (IV) are formed whose ratio depends on the nature of the aryl substituent. The reaction behavior is different to that observed in the reactions of ethyl acetoacetate and its derivatives with the same binucleophiles. -(BRITSUN, V. N.; BORISEVICH, A. N.; ESIPENKO, A. N.; LOZINSKII, M. O.; Russ.