Reaction of fluoroketones with vinyl ethers

Lithium bromide/triethylamine promoted tandem cycloaddition–oxidation reaction: A convenient access to 3-trifluoroacetyl pyrroles from N-alkylidene 2-amino esters and β-trifluoroacetyl vinyl ethyl ether

“…Among those welldeveloped methodologies for constructing 5-membered heterocycles, 1,3-dipolar cycloaddition represents one of the most versatile tools [2]. b-Trifluoroacetyl vinyl ethers were first prepared in 1967 [3], and the existence of polarized C5 5C and reactive trifluoroacetyl group have made them widely used as building blocks for the synthesis of fluorine-containing heterocycles [4].…”