Reaction of carbohydrazide with 1,2-dicarbonyl compounds

Photochromic difurylethene bisaldehyde as potential building block for [AA] and [AB]2 macrocyclization

“…Recent applications of DAE-based macrocycles include switchable molecular cages, 6 single molecule logic gates, 7 and dynamic reversible control of bioactive compound concentration profile in solution. 4 A straightforward one-pot synthetic approach toward DAE-based macrocycles often gives mixtures of open-chain and cyclic oligomers 8 and therefore remains a challenging task. Recently, selective high-yielding procedures for [AB] 2 and [AB] 3 cyclic organosilicon terephthalates 9 and azacrown ethers 10 were reported.…”

Divergent Reactivity of N-Isocyanates with Primary and Secondary Amines: Access to Pyridazinones and Triazinones

“…1,2,4-Triazinones possessing an exocyclic unsaturation are interesting entities given their inherent reactivity yet have seldom been studied. Difficulties in accessing these compounds could explain their scarcity in the literature . In contrast, 5-aminopyridazinones possess broad biological activities and are present in agrochemicals (e.g., norflurazon) as well as pharmaceuticals (e.g., emorfazone).…”