Reaction of 2-R 5-oxo 5-H 6- Ethylcarboxylate 7-phenyl-[1,3,4]thiadiazolo-[3,2-a] pyrimidine with Morpholin and their Properties

Abstract

In this article presents Synthesis of 2-R5-oxo 5-H 6 -Carbomorpholin 7-phenyl 1,3,4-thiadiazolo-[3,2-a] pyrimidine through reaction of 2-R 5 -Oxo 5 -H 6-EthylCarboxilate 7 -phenyl -1, 3,4 -Thiadiazolo-[3,2-a] pyrimidine with morpholin. in particular,for the new antibacterial drugs in these homologousseries of compounds, we have synthesized 2-R5-oxo 5-H 6 -Carbomorpholin 7-phenyl 1,3,4-thiadiazolo-[3,2-a] pyrimidine .The structures of the compounds obtained are set NMR, 13 C, IR-spectroscopy.Keywords: 2-R 5-oxo 5-H 6 -Carbomorpholin 7-phenyl 1,3,4-thiadiazolo-[3,2-a] pyrimidine -2-R 5-Oxo 5-H 6-EthylCarboxilate 7 -phenyl -1, 3, pyrimidine -Morpholin -Synthesis -The reaction.and numerous repor tshave appeared in the literature [8][9][10][11][12]

α-Aminoazoles/azines: key reaction partners for multicomponent reactions

“…The catalyst benzene sulphonamide dibromide was synthesized and employed in the one-pot condensation of 2-amino thiadiazol 328, aromatic aldehydes 4 and acetamide 329 in toluene under reux conditions, which afforded thiadiazole-fused triazine derivatives 330 in excellent yields (Scheme 103). 200 A unique approach to benzothiazole-fused imidazoles 332 was developed by S. G. Balwe and Y. T. Jeong via the ironcatalyzed three-component cascade coupling of 2-aminobenzothiazole 3b, aldehydes 4 and nitroalkane 331 in air. 201 The mechanistic aspect of this unprecedented formation of fused imidazoles includes a sequential aza-Henry reaction and subsequent intramolecular cyclization, followed by denitration.…”

“…The catalyst benzene sulphonamide dibromide was synthesized and employed in the one-pot condensation of 2-amino thiadiazol 328, aromatic aldehydes 4 and acetamide 329 in toluene under reflux conditions, which afforded thiadiazole-fused triazine derivatives 330 in excellent yields ( Scheme 103 ). 200 …”