Reaction of 2-halofluoroalkyl-containing ?-ketoesters with N-dinucleophiles

Synthesis of 2-arylhydrazones of aliphatic fluorine-containing 1,2,3-tricarbonyl compounds and their reactions with dinucleophiles

“…A similar procedure starting from p-anisidine (0.14g, 1.1 mmol), NaNO 2 (0.08g, 1.1 retool), and oxo ester lb (0.33g, 1 retool) gave 0.38g of product 51) (see Table I). Ethyl 4,4,5,5,6,6,7,7,. A similar procedure starting from p-toluidine (0.12g, 1.1 mmol), NaNO 2 (0.08g, 1.l retool), and oxo ester lb (0.33 g, 1 retool) gave 0.34 g of compound 5c (see Table 1).…”

Synthesis of fluorine-containing benzimidazole derivatives

“…Thus it was reported that 2 difluoromethyl 1Н benzimi dazole (2) was obtained by the reaction of o phenylene diamine (1a) with tetrafluoroethylene in an autoclave (135 atm, 136 °С, the yield 50%) 2 or with oxo ester F 2 CHC(O)CBr 2 COOMe (yield 20-30%). 3 But these methods are not preparative ones. In other papers by Russian 4-8 and Japanese authors 9,10 devoted basically to the study of biological activity 4-6 or crystal struc tures 7,8 of fluorine substituted benzimidazoles, no proce dures of their synthesis were given, rather only the reac tants, o phenylenediamine (1a) and hexafluoropropene (in DMF) 4,5,9 or 2 fluoro 2 trifluoromethoxyacetic acid 7 , or Et 2 NCF 2 CH(F)CF 3 (in THF) 10 were mentioned.…”

Fluorine-Containing 2-Functionalized 1,3-Dicarbonyl Compounds for Heterocyclic Synthesis

“…) 37. It should be noted that the reactions of 2-chloro-3-oxo esters (13) with hydrazines go with dehalogenation.…”