Reaction of 1‐(2′,3′‐epoxy‐β‐<b>D</b>‐lyxofuranosyl)uracil with hydrogen fluoride. The unexpected formation of 1‐(3′‐fluoro‐3′‐deoxy‐β‐<b>D</b>‐ribofuranosyl)uracil

Radiohalogenated carbohydrates have been of significant interest to the Nuclear Medicine community since the success of 2‐Deoxy‐2‐fluoro‐glucose (FDG)/positron emission tomography (PET) to measure glucose metabolic rates in humans. This review of this important class of compounds will be written in two parts, and will concentrate on the chemistry. The first part will cover the development of FDG, the many attempts to synthesize other radiohalogenated PET and SPECT analogs, and future prospects of a SPECT analog. The second will cover the synthesis of other radio‐halogenated carbohydrate compounds such as nucleosides, where the halogen is located on the sugar rings, as potential imaging or therapeutic agents. Copyright © 2002 John Wiley & Sons, Ltd.

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Synthesis and Reaction of Pyrimidine Nucleosides

Ueda

1988

Chemistry of Nucleosides and Nucleotides

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Reaction of 1‐(2′,3′‐epoxy‐β‐D‐lyxofuranosyl)uracil with hydrogen fluoride. The unexpected formation of 1‐(3′‐fluoro‐3′‐deoxy‐β‐D‐ribofuranosyl)uracil

Abstract: Das Uracil‐zuckerepoxid (I) reagiert mit HF in Dioxan zu den beiden Spaltprodukten (II) und (III) sowie Uracil (IV).

Cited by 8 publications

References 15 publications

ChemInform Abstract: REACTION OF 1‐(2′,3′‐EPOXY‐β‐D‐LYXOFURANOSYL)URACIL WITH HYDROGEN FLUORIDE. THE UNEXPECTED FORMATION OF 1‐(3′‐FLUORO‐3′‐DEOXY‐β‐D‐RIBOFURANOSYL)URACIL

ChemInform Abstract: REACTION OF 1‐(2′,3′‐EPOXY‐β‐D‐LYXOFURANOSYL)URACIL WITH HYDROGEN FLUORIDE. THE UNEXPECTED FORMATION OF 1‐(3′‐FLUORO‐3′‐DEOXY‐β‐D‐RIBOFURANOSYL)URACIL

Radiohalogenated carbohydrates for use in PET and SPECT

Synthesis and Reaction of Pyrimidine Nucleosides

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